Background of the review: Patient safety culture reflects the perception of processes, norms, and attitudes relating to a culture of preventable errors shared by health professionals in the delivery of care. Developing a culture of safety is a core element of many efforts to improve patient safety and care quality. Aim: The aim of the current review is intended (a) to assess the knowledge of nurses on patient safety (b) to assess the attitude of nurses on patient safety in clinical practice. Methods: The narrative conceptual synthesis method was used to review quantitative studies reporting sources of attitude of nurses towards patient safety culture. The search also was limited to studies conducted between 2011 and 2021 (10 years). The keywords include “patient safety culture”, “patient safety”, “attitude of nurses”, “clinical”, “hospitals” and “health care settings” in various combinations. Finally, 28 studies were identified, of which, 07met the set criteria. The review studies targeted on the student nurses, graduated nurses and nurses practicing in any patient care settings also included the data regarding patient safety culture. The researcher screened the literature and extracted the data. Results: The review results show that the nurses are having sufficient to good level of knowledge regarding patient safety with good practices. The attitude of nurses varies from 50%negative, 50% favorable to positive attitude regarding patient safety. Conclusion: Patient safety is a global health strategy and an ascribe of all health care systems. Nurses spend the maximum time round the clock in coordinating and providing care to the patients are highly involved in strengthening the safety web of patient care. Thus, the nursing staff must update their knowledge, foster a positive attitude regarding patient safety, and embody it into their practice to promote patient safety.