Dietary habits and Helicobacter pylori infection: a cross sectional study at a Lebanese hospital

Assaad, Shafika; Chaaban, Rawan; Tannous, Fida; Costanian, Christy

doi:10.1186/s12876-018-0775-1

Cited by 32 publications

(41 citation statements)

References 48 publications

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“…Similar data were also reported for raw cow milk samples in Japan (Fujimura et al 2002), as well as in Greeks (Angelidis et al 2011) and American (Dore et al 2001) herds. Supporting these data, a recent study reports a higher prevalence of H. pylori positively associated with the consumption of milk (Assaad et al 2018).…”

Section: 2a Foodsupporting

confidence: 53%

Epidemiology, Diagnosis and Risk Factors of Helicobacter pylori Infection

Kotilea

Bontems

Touati

2019

Advances in Experimental Medicine and Biology

112

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Helicobacter pylori is a human-specific pathogen which leads to gastric pathologies including gastric cancer. It is a highly unique bacterium considered as a carcinogenic agent. H. pylori remains a major human health problem, responsible for ~90% of the gastric cancer cases. Approximately four billion individuals have been detected for H. pylori infection worldwide in 2015. At the turn of the 21 st century, the prevalence of H. pylori has been declining in highly industrialized countries of the Western world, whereas prevalence has plateaued at a high level in developing and newly industrialized countries. However, the infection status remains high in immigrants coming from countries with high prevalence of H. pylori infection. H. pylori can be diagnosed by invasive and non-invasive methods. Urea breath test and stool antigens detection are among the most commonly used non-invasive ones. Although the way H. pylori is transmitted remains still unclear, the level of contamination is strongly dependent on the familial and environmental context, with a drastic impact of living conditions with poor hygiene and sanitation. However, familial socioeconomic status is the main risk factor for H. pylori infection among children. In addition, food and water source have a high impact on the prevalence of H. pylori infection worldwide. This chapter highlights the latest knowledge in the epidemiology of H. pylori infection, its diagnosis and critical risk factors responsible for its high prevalence in some populations and geographic areas.

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Section: 2a Foodsupporting

confidence: 53%

Epidemiology, Diagnosis and Risk Factors of Helicobacter pylori Infection

Kotilea

Bontems

Touati

2019

Advances in Experimental Medicine and Biology

112

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“…However, a number of other studies, including one conducted in Lebanon, found no such association, attributing the other positive findings to a birth cohort effect. Our results showed no association between gender and H. pylori detection rates, which is consistent with most of the literature, including local data 15 26–28…”

Section: Discussionsupporting

confidence: 92%

“…A systemic review presented a prevalence varying between 22% and 87.6% in the Eastern Mediterranean region 14. Regarding the investigations done in Lebanon, one study found the prevalence to be 52.4% on histology at a peripheral hospital in north Lebanon 15. The variation of results between our study and the aforementioned study could be due to the fact that it was conducted in a relatively peripheral hospital whereas our study was conducted in a central hospital (north Lebanon vs Beirut).…”

Section: Discussionmentioning

confidence: 99%

Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern population

Ghosn

Kamareddine

Tawk

et al. 2019

BMJ Open Gastroenterol

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ObjectiveCorrea’s cascade is a ‘Model for Gastric Cancer Development’ described by Peleyo Correa. The reversibility of Correa’s cascade remains debatable. The literature contains insufficient data on the specific stage of the cascade during which Helicobacter pylori is detected, treated, and the effect on prognosis. Herein, we aim to determine the prevalence of various precancerous and cancerous gastric lesions in patients presenting with dyspepsia, the prevalence of gastritis and H. pylori infection, the prevalence of duodenal pathology in patients presenting with dyspepsia, identify the stage of H. pylori detection in relation to Correa’s cascade, and investigate a possible relationship between H. pylori and celiac disease.DesignRetrospective cross-sectional study conducted on a middle eastern population at a Lebanese tertiary hospital centre. 1428 patients presenting with dyspepsia underwent gastroscopy with gastric and duodenal biopsies. Variables include age, sex, presence/absence of H. pylori infection, and histopathological analysis of gastric and duodenal biopsies.ResultsBeing above 40 years of age was associated with increased likelihood of exhibiting abnormal gastric biopsy result. Gastritis and metaplasia were detected more frequently than glandular atrophy (p<0.001) with gastritis being present the most (p<0.001). The presence of H. pylori and the gastric biopsy results were not associated with any of the duodenal biopsy results.ConclusionThe burden of H. pylori infection in patients with dyspepsia was high. H. pylori was detected at various precancerous lesions with varying significance. The prevalence of duodenal adenocarcinoma in dyspeptic patients is unexpectedly high. No association between gastric and duodenal pathologies was found.

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“…Our search identified 182 related references, of which 10 papers met our inclusion criteria . The flowchart describing the process of study selection is shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

Yang

et al. 2019

Helicobacter

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Background Various studies reported the relationship between Helicobacter pylori (H pylori) and vitamin D, but there is some controversy around that. This study aimed to conduct a meta‐analysis to clarify the relationship between vitamin D and H pylori infection, and vitamin D and H pylori eradication. Methods Articles published until June 1, 2019, in the PubMed, MEDLINE, and EMBASE databases with English‐language medical studies were searched. According to the inclusion criteria, relevant statistical data were extracted to Microsoft Excel and analyzed by STATA15.1. Results Ten articles were finally included. It was demonstrated that average 25(OH)D level in H pylori‐positive patients was lower than H pylori‐negative (SMD = −0.53 ng/mL, 95% CI = (−0.91, −0.16 ng/mL)). For H pylori eradication individuals, the result showed that average 25(OH)D level in H pylori successful eradication individuals was higher than unsuccessful (SMD = 1.31 ng/mL, 95% CI = [0.60, 2.02 ng/mL]). In addition, individuals with vitamin D deficiency had lower H pylori eradicate rate (OR = 0.09, 95% CI = [0.02, 0.41]). Sensitivity analysis showed that the meta‐analysis results were stable and reliable. Conclusions Vitamin D was a protective factor to H pylori infection. Moreover, vitamin D can improve the success rate of H pylori eradication.

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Dietary habits and Helicobacter pylori infection: a cross sectional study at a Lebanese hospital

Cited by 32 publications

References 48 publications

Epidemiology, Diagnosis and Risk Factors of Helicobacter pylori Infection

Epidemiology, Diagnosis and Risk Factors of Helicobacter pylori Infection

Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern population

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

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