Dietary Habits and Risk of Esophagitis and Barrett’s Esophagus: A Multicenter Italian Case–Control Study

Filiberti, Rosa Angela; Fontana, Vincenzo; Ceglie, Antonella De; Blanchi, Sabrina; Lacchin, Teresa; Matthaeis, M. De; Ignomirelli, Orazio; Cappiello, R.; Rosa, Alessandra; D'Onofrio, V.; Iaquinto, Gaetano; Conio, Mássimo

doi:10.1007/s10620-020-06658-9

Cited by 7 publications

(15 citation statements)

References 48 publications

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“…For fresh fruit, it is widely believed that the intake of fresh fruit can reduce the risk of cancer 41 . Besides, a multicenter case-control study involving 1285 individuals also suggested that the decrease in BE risk was associated with a higher frequency of fresh fruit intake 9 . However, there was still no causal relationship observed between fresh fruit intake and BE in univariate and multivariate MR analysis, which might require larger MR studies as well as better-designed prospective studies to further validate the issue.…”

Section: Discussionmentioning

confidence: 99%

“…In terms of fruit intake, numerous previous studies have shown that fruit intake can reduce the risk of BE 9,40 . Notably, our study supported that dried fruit was a protective factor for BE, rather than fresh fruit, which might be a novel finding.…”

Section: Discussionmentioning

confidence: 99%

Section: (Which Was Not Certified By Peer Review)mentioning

confidence: 99%

“…Numerous observational epidemiological studies have revealed several potential influencing factors for BE, including obesity 3 , type 2 diabetes mellitus (T2DM) 4 , smoking 5 , alcohol drinking 6,7 , coffee and tea intake 8 , and fruit inatke 9 . However, the findings regarding the effects of these dietary and metabolic factors on BE from previous studies are inconsistent even opposite to each other, which make the identification of truly protective and risk factors for BE extremely difficult.…”

Section: Introductionmentioning

confidence: 99%

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Dietary and metabolic factors contributing to Barrett’s esophagus: a univariate and multivariate Mendelian randomization study

Zhuang

et al. 2023

Preprint

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Background: Dietary and metabolic factors have been associated with the risk of Barrett's esophagus (BE) in observational epidemiological studies. However, the aforementioned associations may be influenced by confounding bias. The present study aimed to evaluate these causal relationships through univariate and multivariate Mendelian randomization (MR) analysis. Methods: Genetic instruments associated with dietary and metabolic factors were obtained in the large-scale genome-wide association studies (GWAS), respectively. Summary data for BE were available from a GWAS of 13,358 cases and 43,071 controls of European descent. Univariable MR analysis was initially performed to estimate the causal relationship between exposures and BE. The inverse-variance weighted (IVW) method was adopted as the primary MR analysis. Multivariate MR analysis was further conducted to evaluate the independent effects of exposures on BE. Results: In univariate MR analysis, BE was causally associated with higher body mass index (odds ratio (OR) = 2.575, 95% confidence interval (CI): 2.301-2.880, P = 7.369E-61), larger waist circumference (OR = 2.028, 95% CI: 1.648-2.496, P = 2.482E-11), and smoking per day (OR = 1.241, 95% CI: 1.085-1.419, P = 0.002). Dried fruit intake showed a protective effect on BE (OR = 0.228, 95% CI: 0.135-0.384, P = 2.783E-08), whereas alcohol drinking, coffee intake, tea intake, fresh fruit intake, and type 2 diabetes mellitus were not associated with BE (P = 0.351, P = 0.458, P = 0.125, P = 0.847, P = 0.413, respectively). No pleiotropy was found in the sensitivity analysis. The relationships of obesity, smoking, and dried fruit intake with BE risk remained strong after adjustment. Conclusions: Our study provided MR evidence supporting obesity and smoking were independent risk factors for BE. Conversely, dried fruit intake was a protective factor for BE.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: (Which Was Not Certified By Peer Review)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary and metabolic factors contributing to Barrett’s esophagus: a univariate and multivariate Mendelian randomization study

Zhuang

et al. 2023

Preprint

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“…En ERGE busca descartar la presencia de trastornos de la motilidad esofágica, así como la evaluación preoperatoria en pacientes candidatos a cirugía antirreflujo y posoperatoria de pacientes con disfagia. Aunque no es útil para el diagnóstico de ERGE, puede serlo al proporcionar información complementaria como función y morfología de la UEG y motilidad del cuerpo esofágico (1,17).…”

Section: Manometría Esofágica De Alta Resolución (Mar)unclassified

Enfermedad por reflujo gastroesofágico

Ospina¹,

Borráez-Segura²

2022

Med.

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La enfermedad por reflujo gastroesofágico es una patología multifactorial que ocurre por el paso del contenido gástrico al esófago e incluso a la cavidad oral. La prevalencia actual a nivel mundial es del 8 - 33 % y ocurre a cualquier edad, con un predominio en el género femenino. La incidencia de los síntomas en Suramérica es del 17,6 % y en nuestro país tiene una prevalencia de alrededor del 13 %. Los principales factores de riesgo son el sobrepeso y la obesidad, así como la presencia de hernia hiatal. También se ha relacionado con algunos medicamentos y la ingesta de alimentos como café, chocolate y comidas grasas.Los síntomas típicos son la pirosis y la regurgitación, que generalmente son episódicos. También pueden ocurrir síntomas extraesofágicos de tipo laríngeo y pulmonares como ronquera, aclaramiento de la garganta y tos crónica, asociadas con faringitis, laringitis y en algunos casos fibrosis pulmonar.El diagnóstico se realiza mediante endoscopia de vías digestivas altas y su tratamiento generalmente se basa en cambios en el estilo de vida y en el uso de inhibidores de la bomba de protones, lo que representa un alto gasto para el paciente y las instituciones de salud. En casos avanzados puede ser necesario el manejo quirúrgico.

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Causal relationships between dietary habits and Barrett's esophagus risk: a univariable and multivariable Mendelian randomization study

Junhai,

Suqi,

Beiying

et al. 2024

Food Funct.

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Dietary Habits and Risk of Esophagitis and Barrett’s Esophagus: A Multicenter Italian Case–Control Study

Cited by 7 publications

References 48 publications

Dietary and metabolic factors contributing to Barrett’s esophagus: a univariate and multivariate Mendelian randomization study

Dietary and metabolic factors contributing to Barrett’s esophagus: a univariate and multivariate Mendelian randomization study

Enfermedad por reflujo gastroesofágico

Causal relationships between dietary habits and Barrett's esophagus risk: a univariable and multivariable Mendelian randomization study

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