Dietary habits and their relationship with hormones and metabolism in overweight and obese women with polycystic ovary syndrome

Abstract

This study did not find major differences in dietary habits between PCOS and normoandrogenic control women. Our findings support the hypothesis that specific foods may influence metabolic and hormonal pattern and that this relationship may be differently regulated in PCOS and normoandrogenic women; however, they give little support to the hypothesis of a strong dependence of PCOS status on nutritional factors.

Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model

“…In adulthood (O12 weeks of age), when animals have developed obesity and a PCOS-like phenotype, the use of enforced treadmill exercise may be more effective to improve cardiometabolic and reproductive indices. Similarly, in the clinical setting strong encouragement of high-intensity exercise may provide additional health benefits to dietary caloric restriction (Altieri et al 2013, Moran et al 2013a. The findings of this current study may further translate to lifestage-epigenetic modulation of the hypothalamic-pituitary-gonadal axis via dietary energy restriction and exercise programs to target young adolescent girls diagnosed with PCOS.…”

“…This modest improvement in insulin sensitivity may be mediated by the effects of exercise on insulin signaling in skeletal muscle (Bradley et al 2008). Furthermore this animal model, like clinical PCOS phenotypes, is resistant to dietary and/or exercise improvements in metabolism, thus an 8-week intervention may not be adequate to facilitate marked shifts in insulin-glucose metabolism (Pasquali et al 2011, Altieri et al 2013.…”

“…This has been proposed to be associated with an inherent resistance to metabolic shifts in metabolism due to abnormalities in the hypothalamic-pituitary-ovarian axis in overweight-obese PCOS patients (Pasquali 2012, Altieri et al 2013. It has been proposed that early intervention in prepuberty, adolescence and young adulthood in overweight-obese individuals at risk or in those that have already developed PCOS may be more effective for long-term improvement in reproductive and cardiometabolic risk factors (Neal et al 2009, Ojaniemi et al 2010.…”

“…Lifestyle interventions focusing on diet and exercise are considered first-line treatments to target reductions in total body weight in the overweight-obese PCOS phenotype (Moran et al 2011(Moran et al , 2013a. Several studies implementing dietary caloric restriction in overweight-obese women with PCOS have shown some improvements in hyperinsulinemia, hyperlipidemia, menstrual cyclicity and fertility (Thomson et al 2008, Hamayeli Mehrabani et al 2010, Altieri et al 2013. Exercise training (lasting 10 min or more per week) may improve cardiometabolic risk factors and reproductive indices in women with PCOS (Giallauria et al 2007, Moran et al 2013b.…”

Polycystic Ovarian Syndrome Trend in a Nutshell

“…PCOS would also stimulate depression and reduce the quality of life as women may indulge in unhealthy diets, have cravings for high GI diets and fall short in exercise (8)(9)(10)(11).…”