Dietary habits in a group of patients with multiple sclerosis are similar to those of healthy control subjects

Machado, Stella Boreggio; Cabral, R. S.; Murade, Nadya; Ares, Nayara Cavalcanti; Scorcine, Claudio; Fragoso, Yára Dadalti

doi:10.1590/0004-282x20200065

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…We found no significant differences in MeDi adequacy between PwMS and HC, in line with previous findings ( 25 ). However, although most of the participants in both groups were sufficiently adherent to MeDi, a very low percentage of participants were completely adherent to it (2% PwMS and 1% HC).…”

Section: Discussionsupporting

confidence: 93%

Eating Hubs in Multiple Sclerosis: Exploring the Relationship Between Mediterranean Diet and Disability Status in Italy

et al. 2022

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BackgroundMultiple Sclerosis (MS) is a complex disease in which multiple factors contribute to disability accrual. Mediterranean Diet (MeDi) has shown beneficial effects across neurodegenerative diseases. We hypothesize that specific food habits, rather than global adherence to MeDi, might impact on MS. We aimed to (i) evaluate differences in adherence to MeDi between people living with MS (PwMS) and healthy controls (HC); (ii) characterize eating patterns in PwMS and HC, identifying the most influential MeDi items for each group by the use of network analysis; (iii) explore the relationship between patients' eating habits and disability.Materials and MethodsIn this cross-sectional study, we consecutively recruited 424 PwMS and 165 matched HC. Data were obtained through the administration of self-reported questionnaires. Expanded Disability Status Scale (EDSS) and Fatigue Severity Scale (FSS) were evaluated in the MS population. We performed between-groups comparisons via unpaired two-sample t-test and X2 test as appropriate. We calculated food networks in both MS cases and HC using and tested the association between hub nodes and disability. Finally, we conducted a post-hoc analysis, investigating the relationship between food items, lifestyle factors (smoking, exercise) and clinical outcomes.ResultsMost participants adhered sufficiently to MeDi. Exploring each group separately, fruit, vegetables, cereal, and fish were identified as hubs in PwMS, while meat and alcohol were identified as hubs in HC. Hubs were all inter-correlated, indicating that eating habits of PwMS include a large intake of all the foods identified as hubs. EDSS was predicted by the intake of vegetables (beta = −0.36, p < 0.03) and fish (beta = −0.34, p < 0.02). The model including smoking pack/year, International Physical Activity Questionnaire (IPAQ) score and intake of “negative foods” predicted 6% of the variance in EDSS (p < 0.001), while the model including smoking pack/year and IPAQ score predicted 4% of the variance in FSS (p < 0.001).ConclusionsWe identified a sufficient adherence to MeDi in our population. PwMS showed overall a healthier dietary pattern than HC. Vegetables and fish intake were associated with disability outcomes. Future longitudinal studies applying integrated approaches are needed to understand lifestyle added value to the use of standard pharmacological therapies.

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Section: Discussionsupporting

confidence: 93%

Eating Hubs in Multiple Sclerosis: Exploring the Relationship Between Mediterranean Diet and Disability Status in Italy

et al. 2022

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“…No references were done to the adequacy of their intakes to the US recommendation. Another study ( 30 ), reported no remarkable differences in dietary habits between 34 healthy control subjects and 66 pwMS, except for higher consumption of carbohydrates in patients. When compared to the World Health Organization's recommended daily amounts, both groups had higher protein and lower carbohydrate intakes.…”

Section: Discussionmentioning

confidence: 92%

Ultra-processed foods consumption is associated with multiple sclerosis severity

et al. 2023

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BackgroundMS is a chronic inflammatory neurological and immune-mediated disease of multifactorial etiology. Ultra-processed foods (UPFs) have been generally considered unhealthy due to their poor nutritional value. Emerging evidence suggests that factors other than their nutritional content may play an additional role toward chronic inflammation.AimTo investigate the potential association of UPF consumption and MS severity in a group of MS Italian consecutive patients.MethodsDemographic (age, sex, marital status, educational level), neurological (EDSS, MSSS), and nutritional (anthropometric measures, dietary habits) information were collected. Physical activity and smoking habits were also investigated. Food items were grouped according to the NOVA classification. Patients were classified in two groups based on MS severity (“mild” and “moderate to high”).ResultsHigher UPF consumption was associated with moderate-to-high MS severity compared to lower consumption in both the unadjusted model (OR = 2.28, 95% CI: 1.04–5.01) and after adjustment for potential background (OR = 2.46, 95% CI: 1.04–5.83) and clinical confounding factors (OR = 2.97, 95% CI: 1.13–7.77).ConclusionsAlthough these results are only preliminary and hypothesis generating, it is important to explore how various aspects of the diet may relate to MS severity in order to identify the best strategy to support MS patients over the disease course.

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“…Diet in MS can be assessed via many instruments, such as the Dietary Questionnaire for Epidemiological Studies [ 7 ], food diaries, and shorter measures such as the Short‐Form Food Frequency Questionnaire [ 8 ] and the Diet Habits Questionnaire (DHQ) [ 9 ], used in the present study. Multiple studies have identified associations between diet and MS risk [ 10 , 11 ] disability [ 12 ], fatigue [ 12 , 13 , 14 ], and depression [ 12 , 15 ]; others have found no associations [ 14 , 15 , 16 , 17 , 18 ]. Our group has evaluated the cross‐sectional relationships of diet and disability [ 19 , 20 ], depression [ 21 ], and fatigue [ 22 ] at baseline using the Health Outcomes and Lifestyle In a Sample of people with Multiple sclerosis (HOLISM) cohort, finding that a higher DHQ score was associated with better outcomes.…”

Section: Introductionmentioning

confidence: 99%

Higher‐quality diet and non‐consumption of meat are associated with less self‐determined disability progression in people with multiple sclerosis: A longitudinal cohort study

Simpson‐Yap

Nag

Probst

et al. 2021

Euro J of Neurology

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Background and purpose: Modifiable lifestyle factors, including diet, may affect clinical outcomes in multiple sclerosis (MS). This study assessed the relationships between diet, and disability, fatigue, and depression risk in people with MS.Methods: Participants from the Health Outcomes and Lifestyle In a Sample of people with Multiple sclerosis (HOLISM) international cohort were assessed over 2.5 years.Dietary data were obtained using a modified Diet Habits Questionnaire (DHQ), disability using the calculated Patient-determined MS Severity Score (P-MSSS), fatigue using the Fatigue Severity Scale, and depression risk using the Patient Health Questionnaire-2.Participants reported whether they were experiencing symptoms due to a recent relapse. Cross-sectional and prospective relationships of diet and disease outcomes were explored, adjusted for relevant confounders.Results: Among 1,346 participants, higher DHQ scores showed significant dosedependent associations with lower frequencies of severe disability, fatigue, and depression risk, cross-sectionally. Prospectively, higher baseline DHQ scores were associated with a lower risk of increasing disability, those above the median having 41% and 36% lower risk of increasing disability, and 0.30 P-MSSS points less disability progression, but were not associated with fatigue or depression risk. Meat consumption was associated with 0.22 P-MSSS points higher disability cross-sectionally, while prospectively, baseline meat consumption was associated with 76% higher risk of increasing disability and 0.18 P-MSSS points higher disability progression. Dairy consumption showed mixed associations cross-sectionally and prospectively.Conclusions: These results show that better quality of diet, as well as not consuming meat, were associated with reduced disability progression in people with MS. Substantiation of these findings in other settings may inform opportunities to manage disability progression in people with MS using dietary modifications.

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Dietary habits in a group of patients with multiple sclerosis are similar to those of healthy control subjects

Cited by 5 publications

References 27 publications

Eating Hubs in Multiple Sclerosis: Exploring the Relationship Between Mediterranean Diet and Disability Status in Italy

Eating Hubs in Multiple Sclerosis: Exploring the Relationship Between Mediterranean Diet and Disability Status in Italy

Ultra-processed foods consumption is associated with multiple sclerosis severity

Higher‐quality diet and non‐consumption of meat are associated with less self‐determined disability progression in people with multiple sclerosis: A longitudinal cohort study

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