Dietary habits in adult Japanese patients with atopic dermatitis

Ito, Michiko; Morita, Takashi; Okazaki, Shuzo; Koto, Mototaka; Ichikawa, Yuri; Takayama, Ryoko; Hoashi, Toshihiko; Saeki, Hidehisa; Kanda, Naoko

doi:10.1111/1346-8138.14881

Cited by 15 publications

(15 citation statements)

References 32 publications

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“…The environmental factors other than smoking may be involved in the pathogenesis of PPP. A dietary habit can be one environmental factor as certain nutrients or foods have disease‐modifying effects on chronic inflammatory diseases, 20,21 especially on psoriasis, a skin disease with enhanced TNF‐α/IL‐23/IL‐17 axis. Saturated fatty acids, red meat, simple sugars, or alcohol exacerbate psoriasis via the activation of TNF‐α/IL‐23/IL‐17 axis, gut dysbiosis or suppression of regulatory T cells (Tregs).…”

Section: Introductionmentioning

confidence: 99%

Dietary habits in Japanese patients with palmoplantar pustulosis

Serizawa

Okazaki

Otsuka

et al. 2021

The Journal of Dermatology

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Palmoplantar pustulosis (PPP) is a chronic dermatitis characterized by sterile intra‐epidermal pustules associated with erythema and scales on the palms and soles. Tumor necrosis factor (TNF)‐α/interleukin (IL)‐23/IL‐17 inflammatory pathway may be involved in the pathogenesis of PPP, and the skin lesions manifest the enhanced expression of IL‐8 in keratinocytes and increased levels of antimicrobial peptide cathelicidin, leucine leucine‐37 in vesicles/pustules. Some PPP patients are associated with arthro‐osteitis, called pustulotic arthro‐osteitis (PAO). Dietary habits may modulate the pathogenesis of PPP, however, have not been investigated in PPP patients. We evaluated dietary habits in adult Japanese PPP patients, using a validated, brief‐type self‐administered diet history questionnaire, and compared their results to those of age‐ and sex‐matched healthy controls. The results in PPP patients with PAO were compared to those in the patients without. Japanese PPP patients showed higher body mass indices (BMIs), higher intakes of pulses and sugar/sweeteners, and lower intake of vitamin A, compared to those of healthy controls. The bivariate and multivariable logistic regression analysis showed that PPP was associated with high BMI, high intake of pulses, and low intake of vitamin A. The sodium intake and BMI were positively correlated with palmoplantar pustulosis area and severity index (PPPASI). The linear multivariate regression analysis revealed that sodium intake and BMI were predictors of PPPASI. The age and sodium intake in the patients with PAO were lower than those in the patients without. The bivariate and multivariable logistic regression analysis showed that PAO was negatively associated with age and sodium intake. This is the first study showing the dietary habits in patients with PPP. Further studies should clarify if the dietary intervention to correct the BMI and sodium intake will alter the progress of PPP.

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Section: Introductionmentioning

confidence: 99%

Dietary habits in Japanese patients with palmoplantar pustulosis

Serizawa

Okazaki

Otsuka

et al. 2021

The Journal of Dermatology

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“…The prevalence of AR ↓ Atopic dermatitis Processed foods and some food additives The occurrence and severity of AD ↑ [253,255] Breastfeeding for the first four months The risk of eczema in the first four years ↓ [257] Feeding infants with intensive eHF in the first 4-6 months, avoiding milk and dairy products Prevent the development of AD [257] Feeding eHF after the sixth month Not suppress the development of AD [258] Monounsaturated fatty acid Allergic sensitization in females, mostly no significant associations for males [258] High n−6/n−3 ratio Moderate to severe AD ↑ [260] The intake of n−6 fatty acids Lower in the severe AD group [261] n−3 PUFA docosahexaenoic acid Beneficial impact on AD [262] Supplementation with polyunsaturated fatty acids of the omega−3…”

Section: Environmental Subs Tan Ce S Affec Ting the Epithelial Barrier Smentioning

confidence: 99%

“…Although some studies have indicated that low n‐3 intake is inversely correlated with AD in women and one randomized control trial noted that AD severity decreases after n‐3 supplementation; another studies have found no association between n‐3 intake and AD, and other clinical studies reported that n‐3 supplementation in adults did not show any benefit over placebo in AD. 259 , 260 , 261 , 262 , 263 , 264 Recently, oxidative stress has been shown to induce AD by increasing the pro‐inflammatory response. 265 Studies conducted on children and adults have found an inverse relationship between serum vitamin C and E levels with AD, and supplementation of vitamin E reduced AD symptoms (Table 4 ).…”

Section: Change In Dietary Habits and Allergic Diseasesmentioning

confidence: 99%

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Sözener

Öztürk

Çerçi

et al. 2022

Allergy

221

166

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Environmental exposure plays a major role in the development of allergic diseases.The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external (e.g., chemical pollutants or lifestyle factors), and general external (e.g., broader socioeconomic and psychological contexts) domains, all of which are interrelated. All the factors we are exposed to, from the moment of conception to death, are part of the external exposome. Several hundreds of thousands of new chemicals have been introduced in modern life without our having a full understanding of their toxic health effects and ways to mitigate these effects.Climate change, air pollution, microplastics, tobacco smoke, changes and loss of biodiversity, alterations in dietary habits, and the microbiome due to modernization, urbanization, and globalization constitute our surrounding environment and external exposome. Some of these factors disrupt the epithelial barriers of the skin and mucosal surfaces, and these disruptions have been linked in the last few decades to the increasing prevalence and severity of allergic and inflammatory diseases such as atopic dermatitis, food allergy, allergic rhinitis, chronic rhinosinusitis, eosinophilic

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“…The pathogenesis of AD involves a variety of genetic and environmental factors, including diet. 8 Oral intake of certain nutrients could help regulate AD, including vitamin D, vitamin A, -linolenic acid (GLA), eicosapentaenoic acid (EPA), probiotics, or zinc, via the suppression of abnormal immunity, skin barrier impairment, or pruritus ( Fig. 3).…”

Section: Introductionmentioning

confidence: 99%

“…3). [8][9][10] This article reviews recent studies regarding the regulatory effects of individual nutrients on AD, and possible therapeutic or preventive roles of their oral supplementation in AD.…”

Section: Introductionmentioning

confidence: 99%

Nutrition and atopic dermatitis

2021

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Atopic dermatitis (AD) is a chronic eczematous disease characterized by T helper 2 (Th2)-shifted allergic immunity, skin barrier impairment, and pruritus. Oral intake of certain nutrients could help regulate AD. In patients with AD, serum 25-hydroxyvitamin D levels are reduced, and oral vitamin D supplementation improves AD. Vitamin D increases regulatory T (Treg) cells which promote tolerance to allergens and prevent allergic inflammation, inducing the expression of filaggrin and cathelicidin in keratinocytes. Vitamin A strengthens Treg cells by inducing the expression of Forkhead box P3, and inhibits mediator release from mast cells or eosinophils. Serum levels of linolenic acid and its metabolite, dihomo--linolenic acid, are reduced in patients with AD, and oral -linolenic acid improves AD through anti-inflammatory prostaglandin D1 or E1 derived from dihomo--linolenic acid. Eicosapentaenoic acid and docosahexaenoic acid ameliorate AD by suppressing the production of leukotriene B4, increasing ceramides in the stratum corneum, or through their metabolites, resolvin E1 and D1, resolving inflammation. Probiotics, Lactobacillus or Bifidobacteria, improve the intestinal permeability barrier, and induce Treg cells. Serum, hair, and erythrocyte zinc levels are reduced in patients with AD. Zinc induces Forkhead box P3 expression and increases Treg cells, and zinc-finger protein A20 suppresses the nuclear factor-B-3 dependent expression of inflammatory cytokines or cell-adhesion molecules. Oral supplementation of the above nutrients might play therapeutic or preventive roles for AD.

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Dietary habits in adult Japanese patients with atopic dermatitis

Cited by 15 publications

References 32 publications

Dietary habits in Japanese patients with palmoplantar pustulosis

Dietary habits in Japanese patients with palmoplantar pustulosis

Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Nutrition and atopic dermatitis

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