Dietary habits, nutritional status and risk of a first demyelinating event: an incident case-control study in a southern European cohort

Cavalla, Paola; Golzio, P.; Maietta, D.; Bosa, Chiara; Pasanisi, Maria Barbara; Alteno, Anastasia; Schillaci, Valentina; Costantini, Gianfranco; Durelli, Paola; Cuffini, Erica; Panizzolo, Stefania; Francesco, Antonella De; Chiò, Adriano; Vercellino, Marco

doi:10.1007/s10072-022-05908-0

Cited by 5 publications

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, pro-inflammatory diets (based on the dietary inflammation index [123] ) enriched in added sugars and ultra-processed foods are associated with increased FDE odds [124] and increased risk of autoimmune demyelinating diseases [125,126] . Corroborating these findings, a case-control study reported that low intake of fiber, vitamin D, and α-linolenic acid associated with increased odds of FDE [127] .…”

Section: Human Ms Dietary Studiesmentioning

confidence: 93%

Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

Plafker¹,

Titcomb²,

Zyla-Jackson³

et al. 2023

Immunometabolism

View full text Add to dashboard Cite

This review summarizes the cellular and molecular underpinnings of autoimmune demyelinating optic neuritis (ADON), a common sequela of multiple sclerosis and other demyelinating diseases. We further present nutritional interventions tested for people with multiple sclerosis focusing on strategies that have shown efficacy or associations with disease course and clinical outcomes. We then close by discuss the potential dietary guidance for preventing and/or ameliorating ADON.

show abstract

Section: Human Ms Dietary Studiesmentioning

confidence: 93%

Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

Plafker¹,

Titcomb²,

Zyla-Jackson³

et al. 2023

Immunometabolism

View full text Add to dashboard Cite

show abstract

“…In patients with the first episode of demyelinating, a higher consumption of simple carbohydrates and a lower consumption of insoluble fiber were observed [17]. Fitzgerald et al in a study evaluating the quality of the diet of MS patients showed that a diet richer in fiber, that is, fruits, vegetables, legumes and whole grains, and poorer in simple sugars (sugar-sweetened sweets and drinks) was associated with a lower level of disability [20].…”

Section: Carbohydratesmentioning

confidence: 99%

“…A recently published case-control study in a southern European cohort showed that patients with the first demyelinating episode admitted to lower plant protein intake and higher animal protein intake compared to healthy controls [ 17 ]. The role of animal proteins in the risk of developing multiple sclerosis is controversial.…”

Section: Proteinsmentioning

confidence: 99%

“…In patients with the first episode of demyelinating, a higher consumption of simple carbohydrates and a lower consumption of insoluble fiber were observed [ 17 ]. Fitzgerald et al .…”

Section: Carbohydratesmentioning

confidence: 99%

“…The high consumption of simple carbohydrates has been suggested to be generally pro-inflammatory [ 50 ], but its role in MS requires further research. High dietary fiber intake can modulate the intestinal microbiota and the end products of fiber fermentation, short-chain fatty acids (SCFA), can modify the immune microenvironment of the gut by inducing regulatory T lymphocytes and protect against autoimmune diseases [ 17 ]. However, in relation to MS, there are insufficient research results.…”

Section: Carbohydratesmentioning

confidence: 99%

See 2 more Smart Citations

Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

Zielińska¹,

Michońska²

2022

ppn

View full text Add to dashboard Cite

Purpose: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system in which multifocal damage to the brain and spinal cord occurs. The etiology of MS remains unclear but it is often recognized by researchers as a multifactorial disease that involves autoimmune and genetic predisposition combined with environmental influences (e.g., low vitamin D levels, smoking, obesity). An adequate and balanced diet can be extremely helpful in improving the condition of MS patients, effectively supporting pharmacological therapy. The purpose of the study was to investigate whether, and if so, to what extent, the intake of macronutrients, vitamins, and microelements may affect the course of MS. Views: The review presents data from studies published between 2017 and 2022. Conclusions: There are numerous studies on the role of specific dietary components in the treatment of MS, but the results are still limited. More work is needed to define the tools required for the assessment of patients' eating habits because dietary factors can affect the functioning and quality of life of MS patients and should therefore be evaluated to assist in comprehensive treatment and recovery.

show abstract

Inverse association between Mediterranean diet and risk of multiple sclerosis

2023

View full text Add to dashboard Cite

Objective: There is some evidence implicating diet in the development of inflammatory diseases. We aimed to study the influence of dietary habits on the risk of developing multiple sclerosis (MS). Methods: We used a population-based case–control study recruiting incident cases of MS (1953 cases, 3557 controls). Subjects with different dietary habits 5 years prior to MS diagnosis were compared regarding MS risk by calculating odds ratios (OR) with 95% confidence intervals (CI) using logistic regression models. Adjustment was made for a large number of environmental and lifestyle habits, including ancestry, smoking, alcohol consumption, body mass index, physical activity, and sun exposure habits. Results: Mediterranean diet was associated with lower risk of developing MS (adjusted OR = 0.54, 95% CI: 0.34–0.86, p = 0.009), compared with Western-style diet. There was no significant association between vegetarian/vegan diet and MS risk (adjusted OR = 0.96, 95% CI: 0.75–1.24, p = 0.976), nor between diet with low glycemic index and MS risk (adjusted OR = 0.93, 95% CI: 0.60–1.42, p = 0.518). Conclusions: Mediterranean diet may exert a protective influence regarding the risk of subsequently developing MS compared with Western-style diet.

show abstract

Dietary habits, nutritional status and risk of a first demyelinating event: an incident case-control study in a southern European cohort

Cited by 5 publications

References 36 publications

Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

Inverse association between Mediterranean diet and risk of multiple sclerosis

Contact Info

Product

Resources

About