Dietary Habits of Mongolian People, and Their Influence on Lifestyle-Related Diseases and Early Aging

Komatsu, Fumio; Kagawa, Yasuo; Kawabata, Takeshi; Kaneko, Yoshinori; Purvee, Baatar; Otgon, Jugder; Chimedregzen, Ulziiburen

doi:10.2174/1874609810801020084

Cited by 22 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, epidemiological evidence of habit 77,78 supports the close relationship between clock genes (sleep, 19,32 breakfast, 78 and shift work 58,59 ) and telomere length 53 that is shortened by ROS 25 and obesity (Figure 4). Oxidative stress and obesity were related to short lifespan in a nutritional and clinical survey of Mongolians.…”

Section: Conscientiousness As a Predictor Of Healthspanmentioning

confidence: 71%

See 1 more Smart Citation

From clock genes to telomeres in the regulation of the healthspan

Kagawa

2012

Nutrition Reviews

Self Cite

View full text Add to dashboard Cite

Biological clocks are classified into oscillatory (clock genes) and unidirectional hourglass clocks (telomeres). Clock genes align behavioral and biochemical processes with the day/night cycle. Telomeres, the repeated series of DNA sequences that cap the ends of chromosomes, become shorter during cell division. Shortened telomeres have been documented in various pathological states associated with aging. Human activity is driven by NADH and ATP produced from nutrients, and the resulting NAD and AMP play a predominant role in energy regulation. Caloric restriction increases both AMP and NAD and is known to extend the healthspan (healthy lifespan) of animals. Silent information regulator T1 (SIRT1), the NAD-dependent deacetylase, attenuates telomere shortening, while peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a master modulator of gene expression, is phosphorylated by AMP kinase and deacetylated by SIRT1. Thus, PGC-1α is a key component of the circadian oscillator that integrates the mammalian clock and energy metabolism. Reactive oxygen species produced in clock mutants result in telomere shortening. The circadian rhythms produced by clock genes and lifestyle factors are ultimately controlled by the human brain and drive homeostatic and hedonic feeding and daily activity.

show abstract

Section: Conscientiousness As a Predictor Of Healthspanmentioning

confidence: 71%

“…Oxidative stress and obesity were related to short lifespan in a nutritional and clinical survey of Mongolians. 77 A systematic review of 153 articles revealed a relationship between obesity and skipping breakfast or eating frequency. 78…”

Section: Conscientiousness As a Predictor Of Healthspanmentioning

confidence: 99%

From clock genes to telomeres in the regulation of the healthspan

Kagawa

2012

Nutrition Reviews

Self Cite

View full text Add to dashboard Cite

show abstract

“…Low levels of the human Se status may be associated with a significant oxidant stress and low longevity as shown in previous reports for residents of Mongolia (Komatsu et al, 2008(Komatsu et al, , 2011. The low iodine status of Mongolia (Enhtuya, 2003) may be considered as an additional risk factor, capable to enhance Se deficiency, as Se and I metabolisms are known to be inseparably linked (Banuelos, Lin Zhu-Qing, & Yin Xuebin, 2014).…”

Section: The Human Se Statusmentioning

confidence: 88%

Health Risk Connected With the Low Selenium Levels in Foodstuffs of Mongolia

Erdenetsogt¹,

Golubkina²,

Nadegkin³

et al. 2014

ENRR

View full text Add to dashboard Cite

The objective of this study was to evaluate health risks connected with the selenium level in foodstuffs of Mongolia. Meat of domestic animals from 17 provinces of Mongolia (n=142), wheat (n=30), garlic, eggs, blood serum samples from the Dornogovi province of Mongolia (n=40) were obtained to determine the selenium level by fluorimetric method. The Se levels were 105-346 (173±42) µg/kg d.w. in meat of domestic animals, 6-34 (18±10) µg/kg in wheat, 68±2 µg/kg in garlic and 13.14±0.54 µg/100 g in eggs. Contrary to areas of marginal Se deficiency (Moscow region) Mongolia was characterized by elevated Se levels in lung of domestic animals compared to liver concentrations of the element. Calculated Se intake with meat by residents of Mongolia varied from 8.7 to 17 µg/person/day. High concentrations of Cd, Pb and Ni in wheat of Selenge, Tuv and Dornod provinces accordingly, Al in Selenge grain and Ni and Pb in spring garlic of Zavkhan province presented additional health risks for the population. The mean serum Se level of the Dornogovi population was 71±5.7 μg/l, indicating a lower level of glutathione peroxidase activity. The study revealed that the most pronounced Se deficiency in foodstuffs of Mongolia was typical for the Northern and Eastern provinces of the country. Development of effective program of the Se status optimization in Mongolia should become one of the most important health care intervention priority so as to reduce the ecological risk arising from Se deficiency in Mongolia.

show abstract

“…17,18) In a recent study, subjects with Parkinsonism and arthritis showed high levels of Mn and Al accumulated in their brains. 19) Chronic Mn exposure shows many pathological features in common with PD. 20,21) DA deficiency has been shown to occur in chronic Mn poisoning in squirrel monkeys and rabbits.…”

Section: Discussionmentioning

confidence: 99%

Combined Low Calcium and Lack Magnesium Is a Risk Factor for Motor Deficit in Mice

Taniguchi

Nakagawasai

Tan-No

et al. 2013

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

The populations of the Kii Peninsula in Japan and of Guam present high incidences of amyotrophic lateral sclerosis and Parkinsonism-dementia complex. It is thought that low levels of calcium (Ca) and magnesium (Mg) in the drinking water are involved in the pathogenesis of these diseases. The present study aimed to test the hypothesis that catalepsy, behavioral immobility and a Parkinsonian symptom results from functionally impaired dopaminergic neurons in mice fed low amounts of Ca and Mg (LCa/Mg). A group of mice fed a LCa/Mg diet for 6 weeks was compared to a control group on a standard diet. Cataleptic symptoms such as akinesia and rigidity were measured by the bar test. The anti-parkinsonian drugs dopamine (DA) precursor L-3,4-dihydroxy phenylamine (L-DOPA), the selective DA receptor D 2 agonist bromocriptine, and the DA releaser amantadine were tested for their effects on induced catalepsy. The mice developed catalepsy after 3 weeks on the LCa/Mg diet. LCa/Mg dietinduced catalepsy was improved by the administration of L-DOPA (50-200 mg/kg i.p.) in combination with benserazide (25 mg/kg i.p.), or of bromocriptine (0.25-4 mg/kg i.p.) or of amantadine (5-20 mg/kg i.p.). Immunohistochemical staining revealed that the intensity of tyrosine hydroxylase fluorescence was significantly decreased in the substantia nigra at the 6th week of LCa/Mg feeding in comparison with pair-fed controls. These results suggest that catalepsy in LCa/Mg mice results from hypofunction of the dopaminergic neurons. Moreover, our results support the hypothesis that LCa/Mg intake is one etiological factor in neurodegenerative disorders, including Parkinson's disease.

show abstract

Dietary Habits of Mongolian People, and Their Influence on Lifestyle-Related Diseases and Early Aging

Cited by 22 publications

References 0 publications

From clock genes to telomeres in the regulation of the healthspan

From clock genes to telomeres in the regulation of the healthspan

Health Risk Connected With the Low Selenium Levels in Foodstuffs of Mongolia

Combined Low Calcium and Lack Magnesium Is a Risk Factor for Motor Deficit in Mice

Contact Info

Product

Resources

About