Dietary Heat-Killed &lt;i&gt;Lactobacillus brevis&lt;/i&gt; SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice

Higo-Yamamoto, Sayaka; Yamamoto, Saori; Miyazaki, Kuniyuki; Nakakita, Yasukazu; Kaneda, Hirotaka; Takata, Yoshinobu; Nakamura, Takeshi; Oishi, Katsutaka

doi:10.3177/jnsv.65.164

Cited by 17 publications

(10 citation statements)

References 24 publications

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“…However, excessive cytokines might still disturb the sleep structure (61,67). Other proposed explanations for the sleepimproving effects of PS128 TM on the regulation of wakefulness or sleep might be related to several neurotransmitters, such as the increase in GABA (68), decrease in orexin levels or increase in inhibitory adenosine levels in the ventrolateral preoptic nucleus, striatum, hypothalamus, hippocampus, and prefrontal cortex (62,69). Other non-invasive methods for monitoring changes in sleep stages may be required to clarify how PS128 TM affects the sleep structure among highly stressed individuals.…”

Section: Discussionmentioning

confidence: 99%

Psychobiotic Supplementation of PS128TM Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study

Wu²,

Tsai³

et al. 2021

Front. Nutr.

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Background: Information technology (IT) is an industry related to the production of computers, information processing, and telecommunications. Such industries heavily rely on the knowledge and solutions provided by IT specialists. Previous reports found that the subjective stress scores were higher in IT specialists who developed diabetes, hypertension, and depression. Specific probiotics, known as psychobiotics, may alleviate stress and mood symptoms. This study aimed to examine whether an 8-week intervention of a novel psychobiotic, Lactobacillus plantarum PS128TM (PS128TM), improved self-perceived stress and mood symptoms among high-stress IT specialists.Methods: This open-label, single-arm, baseline-controlled study included IT specialists from a large IT company in Northern Taiwan. Participants with a Perceived Stress Scale (PSS) 10-item version score of 27 or higher were included. Participants were asked to take two capsules containing PS128TM powder, equivalent to 20 billion colony-forming units, daily. Self-report measures, such as the Job Stress Scale, Visual Analog Scale of Stress, the Insomnia Severity Index, the State and Trait Anxiety Index, the Questionnaire for Emotional Trait and State, the Patient Health Questionnaire, the Quality of Life Enjoyment and Satisfaction Questionnaire, and Gastrointestinal Severity Index were compared at baseline and at the end of the trial period. The primary outcome was a 20% reduction in the PSS score at endpoint. Objective measures included salivary levels of stress biomarkers, including cortisol, α-amylase, immunoglobulin A, lactoferrin, and lysozymes, as well as results of the Test of Attentional Performance.Results: Of the 90 eligible IT specialists, 36 met the inclusion criteria. After the 8-week trial period, significant improvements in self-perceived stress, overall job stress, job burden, cortisol level, general or psychological health, anxiety, depression, sleep disturbances, quality of life, and both positive and negative emotions were found.Conclusion: Our results suggest that PS128TM has the distinct advantage of providing stress relief and can improve mental health for people with a high-stress job. Future placebo-controlled studies are warranted to explore the effect and underlying mechanisms of action of PS128TM.Clinical Trial Registration:https://clinicaltrials.gov/ (identifier: NCT04452253-sub-project 2).

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Section: Discussionmentioning

confidence: 99%

Psychobiotic Supplementation of PS128TM Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study

Wu²,

Tsai³

et al. 2021

Front. Nutr.

View full text Add to dashboard Cite

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“…Finally, an application of the method to visualize electroencephalograms (EEG) during sleep is presented. The frequency of the brain waves changes according to the state of sleep/activity [11,12]. In addition, even during sleep, delta waves are predominant in NREM (non-rapid eye movement) sleep, while the percentage of theta waves increases in REM (rapid eye movement) sleep.…”

Section: Expected Resultsmentioning

confidence: 99%

Simple and Quick Visualization of Periodical Data Using Microsoft Excel

Oike

Ogawa

Oishi

2019

MPs

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Actograms are well-established methods used for visualizing periodic activity of animals in chronobiological research. They help in the understanding of the overall characteristics of rhythms and are instrumental in defining the direction of subsequent detailed analysis. Although there exists specialized software for creating actograms, new users such as students and researchers from other fields often find it inconvenient to use. In this study, we demonstrate a fast and easy method to create actograms using Microsoft Excel. As operations in Excel are simple and user-friendly, it takes only a few minutes to create an actogram. Using this method, it is possible to obtain a visual understanding of the characteristics of rhythms not only from typical activity data, but also from any kind of time-series data such as body temperature, blood sugar level, gene expressions, sleep electroencephalogram, heartbeat, and so on. The actogram thus created can also be converted to the "heatogram” shown by color temperature. As opposed to conventional chronograms, this new type of chronogram facilitates easy understanding of rhythmic features in a more intuitive manner. This method is therefore convenient and beneficial for a broad range of researchers including students as it aids in the better understanding of periodic phenomena from a large amount of time-series data.

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“…In another study, high GABA content produced by Lb. brevis SBC8803 improved chronic sleep disorders induced by psychophysiological stress in mice ( Higo-Yamamoto et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Potential of γ-Aminobutyric Acid-Producing Leuconostoc mesenteroides Strains Isolated from Kimchi as a Starter for High-γ-Aminobutyric Acid Kimchi Fermentation

Ahn,

Park

2023

Prev. Nutr. Food Sci.

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γ-Aminobutyric acid (GABA)-producing Leuconostoc mesenteroides K1501 and K1627, isolated from kimchi, exhibited the highest GABA production in 1% monosodium glutamic acid. Both strains showed high survival rates of approximately 87% in artificial gastric juice (pH 3.0) and >80% in 0.1% artificial bile salt fluid. The survival rate was approximately 28% in 0.3% artificial bile salt fluid and 0% in 0.5% artificial bile salts. Both strains showed excellent adhesion to intestinal epithelial cells (>99%). Furthermore, it was observed that growth was not inhibited at 2% salt concentration; however, it was slightly retarded at salt concentrations of 3% and 4%. Moreover, L. mesenteroides K1501 and K1627 inhibited the growth of certain species of Lactobacillus , whose presence in kimchi fermentation is undesirable. Therefore, L. mesenteroides K1501 and K1627 have the potential to be used as starter organisms for functional GABA-rich kimchi.

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Dietary Heat-Killed <i>Lactobacillus brevis</i> SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice

Cited by 17 publications

References 24 publications

Psychobiotic Supplementation of PS128TM Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study

Psychobiotic Supplementation of PS128TM Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study

Simple and Quick Visualization of Periodical Data Using Microsoft Excel

Potential of γ-Aminobutyric Acid-Producing Leuconostoc mesenteroides Strains Isolated from Kimchi as a Starter for High-γ-Aminobutyric Acid Kimchi Fermentation

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