Dietary Indole-3-Carbinol Alleviated Spleen Enlargement, Enhanced IgG Response in C3H/HeN Mice Infected with Citrobacter rodentium

Wu, Yanbei; Wang, Jing; He, Qiang; Yu, Liangli; Pham, Quynhchi; Cheung, Lumei; Zhang, Zhi; Kim, Young S.; Smith, Allen; Wang, Thomas T.Y.

doi:10.3390/nu12103148

Cited by 4 publications

(1 citation statement)

References 43 publications

(65 reference statements)

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“…We previously published I3C, a naturally derived AhR ligand and molecule found in cruciferous vegetables, was effective at reducing disease severity in animal models of colitis [13], which was similarly reported by others [29][30][31][32][33]. In one of the earliest reports of this by Li et al, the researchers established that I3C-mediated protective effects were dependent on AhR since global knockout of AhR in mice prevented I3C from reducing disease severity in the DSS model [34].…”

Section: Discussionmentioning

confidence: 52%

Aryl Hydrocarbon Receptor Regulates Muc2 Production Independently of IL-22 during Colitis

Saxena,

Mitchell,

Bogdon

et al. 2024

IJMS

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We previously reported that an aryl hydrocarbon receptor (AhR) ligand, indole-3-carbinol (I3C), was effective at reducing colitis severity through immune cell-mediated interleukin-22 (IL-22) production. Intestinal epithelial cells (IECs) are also involved in regulating colitis, so we investigated their AhR-mediated mechanisms in the current report. A transcriptome analysis of IECs in wildtype (WT) mice revealed that during colitis, I3C regulated select mucin proteins, which could be attributed to goblet cell development. To address this, experiments under in vivo colitis (mice) or in vitro colon organoid conditions were undertaken to determine how select mucin proteins were altered in the absence or presence of AhR in IECs during I3C treatment. Comparing WT to IEC-specific AhR knockout mice (AhRΔIEC), the results showed that AhR expression was essential in IECs for I3C-mediated protection during colitis. AhR-deficiency also impaired mucin protein expression, particularly mucin 2 (Muc2), independently of IL-22. Collectively, this report highlights the important role of AhR in direct regulation of Muc2. These results provide justification for future studies aimed at determining how AhR might regulate select mucins through mechanisms such as direct transcription binding to enhance production.

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Section: Discussionmentioning

confidence: 52%

Aryl Hydrocarbon Receptor Regulates Muc2 Production Independently of IL-22 during Colitis

Saxena,

Mitchell,

Bogdon

et al. 2024

IJMS

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Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms

Amarakoon

Lee

Tamia

et al. 2023

Annu. Rev. Food Sci. Technol.

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Indole-3-carbinol (I3C) is a bioactive phytochemical abundant in cruciferous vegetables. One of its main in vivo metabolites is 3,3′-diindolylmethane (DIM), formed by the condensation of two molecules of I3C. Both I3C and DIM alter multiple signaling pathways and related molecules controlling diverse cellular events, including oxidation, inflammation, proliferation, differentiation, apoptosis, angiogenesis, and immunity. There is a growing body of evidence from both in vitro and in vivo models that these compounds possess strong potential to prevent several forms of chronic disease such as inflammation, obesity, diabetes, cardiovascular disease, cancer, hypertension, neurodegenerative diseases, and osteoporosis. This article reviews current knowledge of the occurrence of I3C in nature and foods, along with the beneficial effects of I3C and DIM concerning prevention and treatment of human chronic diseases, focusing on preclinical studies and their mechanisms of action at cellular and molecular levels.

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Cruciferous Vegetables and Their Bioactive Metabolites: from Prevention to Novel Therapies of Colorectal Cancer

Ağagündüz

Şahin

Yılmaz

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The Brassicaceae family, known as cruciferous vegetables, includes many economically important species, mainly edible oil plants, vegetable species, spice plants, and feed plants. Cruciferous vegetables are foods rich in nutritive composition and are also a good source of dietary fiber. Besides, cruciferous vegetables contain various bioactive chemicals known as glucosinolates and S-methyl cysteine sulfoxide, including sulphur-containing cancer-protective chemicals. Numerous studies have reported that daily intake of sulphurous vegetables helps prevent cancer formation and reduces cancer incidence, especially in colorectal cancer, through various mechanisms. The potential mechanisms of these compounds in preventing cancer in experimental studies are as follows: protecting cells against DNA damage, inactivating carcinogenic substances, showing antiviral and antibacterial effects, triggering apoptosis in cells with disrupted structure, inhibiting tumour cell migration causing metastasis and the development of tumour-feeding vessels (angiogenesis). These beneficial anticancer effects of cruciferous vegetables are generally associated with glucosinolates in their composition and some secondary metabolites, as well as other phenolic compounds, seed oils, and dietary fiber in the literature. This review aims to examine to the roles of cruciferous vegetables and their important bioactive metabolites in the prevention and treatment of colorectal cancer.

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Dietary Indole-3-Carbinol Alleviated Spleen Enlargement, Enhanced IgG Response in C3H/HeN Mice Infected with Citrobacter rodentium

Cited by 4 publications

References 43 publications

Aryl Hydrocarbon Receptor Regulates Muc2 Production Independently of IL-22 during Colitis

Aryl Hydrocarbon Receptor Regulates Muc2 Production Independently of IL-22 during Colitis

Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms

Cruciferous Vegetables and Their Bioactive Metabolites: from Prevention to Novel Therapies of Colorectal Cancer

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