Dietary Inflammatory Index and Biomarkers of Lipoprotein Metabolism, Inflammation and Glucose Homeostasis in Adults

Phillips, Catherine M.; Shivappa, Nitin; Hébert, James R.; Perry, Ivan J.

doi:10.3390/nu10081033

Cited by 144 publications

(140 citation statements)

References 51 publications

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“…Regular physical activity and replacement of sedentary behaviour with moderate to vigorous physical activity have been associated with more favourable inflammatory profiles in adults . On the other hand, adverse lifestyle habits such as smoking and alcohol consumption have been linked with elevated inflammatory status and more pro‐inflammatory diets, in line with our findings. Specific nutrients also are considered to be anti‐inflammatory, such as fibre, folate and vitamins E and C .…”

Section: Discussionsupporting

confidence: 90%

“…8,9 The literature-derived Dietary Inflammation Index (DII ® ) was developed to characterize the inflammatory potential of an individual's diet on a spectrum from anti-to pro-inflammatory. 10 The DII, which is validated against several inflammatory biomarkers in numerous populations, 11,12 including an Irish adult cohort, 13 has been associated with a range of health outcomes including cancer, asthma, anthropometric measures, cardiometabolic health, metabolic syndrome (MetS) and adverse mental health outcomes. [14][15][16] Although less well-studied in pregnancy, the DII score positively correlates with interval changes in high-sensitivity CRP during pregnancy.…”

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confidence: 99%

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Intergenerational associations of dietary inflammatory index with birth outcomes and weight status at age 5 and 9: Results from the Lifeways cross‐generation cohort study

et al. 2019

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Summary Background Maternal diet and chronic inflammation may influence early‐life offspring health. No comparative data regarding intergenerational associations between dietary inflammation and offspring growth exist. Objective To investigate potential associations between parental and grandparental dietary inflammatory index (DII®) scores with offspring birth outcomes and childhood adiposity. Methods This analysis of the Lifeways Study includes 1082 mother‐child pairs, 333 index‐child's fathers and 707 grandparents. Energy‐adjusted DII (E‐DII) scores were derived from a validated FFQ for all adults. Birth outcomes were abstracted from hospital records. Childhood BMI was determined at age 5 and 9. Logistic regression and mediation analyses using the PROCESS macro for SPSS were performed. Results Higher maternal E‐DII scores, reflecting a more pro‐inflammatory diet, were associated with increased risk of low birthweight (LBW), BW < 2500 g (OR:1.20, 95%CI:1.02–1.47, p = 0.03). Higher maternal grandmothers' (MGM) E‐DII scores were associated with increased risk of macrosomia (OR:1.35, 95% CI:1.02–1.79, p = 0.03) and with increased risk of an overweight grandchild at age 9 (OR:1.47, 95% CI:1.26–1.72, p = 0.02). Results from the mediation analyses revealed a significant total effect between MGMs' E‐DII scores and grandchild's BW. Higher father's and paternal grandmothers' (PGM) E‐DII scores were associated with greater risk of childhood overweight/obesity at 5 years (OR:1.03, 95%CI:1.01–1.19, p = 0.04 and OR:1.07, 95%CI:1.05–1.09, p = 0.01, respectively). The association with the PGMs' E‐DII persisted at age 9 (OR:1.13, 95%CI:1.01–1.90, p = 0.04). Conclusions Dietary inflammation is associated with adverse offspring birth outcomes and childhood adiposity. A more pro‐inflammatory maternal line diet appears to influence early‐life growth, whereas paternal line dietary inflammation appears to influence childhood obesity.

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Section: Discussionsupporting

confidence: 90%

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confidence: 99%

Intergenerational associations of dietary inflammatory index with birth outcomes and weight status at age 5 and 9: Results from the Lifeways cross‐generation cohort study

et al. 2019

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“…Neufcourt et al reported that there was no significant relationship between WC and DII 21 , which was inconsistent with the results of the present study. On the other hand, some studies have shown contradictory results 22,25,26 . The relationship between WC and DII can be interpreted as follows; Since the WC measures abdominal obesity, it can have an important role in the prediction of inflammatory factors 41 .…”

Section: Discussionmentioning

confidence: 99%

Dietary inflammatory index and metabolic syndrome in Iranian population (Fasa Persian Cohort Study)

Ariya

Shahraki

Farjam

et al. 2020

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Metabolic syndrome (MetS) is one of the risk factors for all causes of mortality. Inflammation is an important risk factor for MetS. The present cross-sectional study aimed to investigate the relationship between MetS and pro-inflammatory diet by using the food inflammation index (DII). This study consists of 10,017 participants with an age range of 35 to 70 years. The Fasa Cohort Study (FACS) population (Fars Province, Iran) was used to collect data. The DII was estimated according to Shivappa et al. method using a validated 125-item FFQ. To determine the association between MetS components and DII Logistic regression was used (P > 0.05). The overall mean of DII was − 0.89 ± 1.74. However, adjusted multinomial logistic regression indicates each unit increase in waist circumference (WC) (OR 0.98, 95% CI 0.96–0.99) and HDL-C (OR 0.99, 95% CI 0.98–0.99) was associated with significantly decreased odds of being in the 4th DII quartile in men and all participations respectively, there is no statistically significant relationship between MetS and DII. Overall, although people in the highest quartile of inflammatory food consumption had more likely to develop MetS, this relationship was not statistically significant among males and females.

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“…more negative) E-DII scores indicate more anti-inflammatory diets. The E-DII score has been construct validated and consistently associated with elevated inflammatory biomarker levels such as IL-6 (27) , TNF-α (27) and C-reactive protein (28) .…”

Section: Energy-adjusted Dietary Inflammatory Index Score Calculationmentioning

confidence: 99%

Dietary inflammatory potential in relation to the gut microbiome: results from a cross-sectional study

et al. 2020

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Abstract Diet has direct and indirect effects on health through inflammation and the gut microbiome. We investigated total dietary inflammatory potential via the literature-derived index (Dietary Inflammatory Index (DII®)) with gut microbiota diversity, composition and function. In cancer-free patient volunteers initially approached at colonoscopy and healthy volunteers recruited from the medical centre community, we assessed 16S ribosomal DNA in all subjects who provided dietary assessments and stool samples (n 101) and the gut metagenome in a subset of patients with residual fasting blood samples (n 34). Associations of energy-adjusted DII scores with microbial diversity and composition were examined using linear regression, permutational multivariate ANOVA and linear discriminant analysis. Spearman correlation was used to evaluate associations of species and pathways with DII and circulating inflammatory markers. Across DII levels, α- and β-diversity did not significantly differ; however, Ruminococcus torques, Eubacterium nodatum, Acidaminococcus intestini and Clostridium leptum were more abundant in the most pro-inflammatory diet group, while Akkermansia muciniphila was enriched in the most anti-inflammatory diet group. With adjustment for age and BMI, R. torques, E. nodatum and A. intestini remained significantly associated with a more pro-inflammatory diet. In the metagenomic and fasting blood subset, A. intestini was correlated with circulating plasminogen activator inhibitor-1, a pro-inflammatory marker (rho = 0·40), but no associations remained significant upon correction for multiple testing. An index reflecting overall inflammatory potential of the diet was associated with specific microbes, but not overall diversity of the gut microbiome in our study. Findings from this preliminary study warrant further research in larger samples and prospective cohorts.

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Dietary Inflammatory Index and Biomarkers of Lipoprotein Metabolism, Inflammation and Glucose Homeostasis in Adults

Cited by 144 publications

References 51 publications

Intergenerational associations of dietary inflammatory index with birth outcomes and weight status at age 5 and 9: Results from the Lifeways cross‐generation cohort study

Intergenerational associations of dietary inflammatory index with birth outcomes and weight status at age 5 and 9: Results from the Lifeways cross‐generation cohort study

Dietary inflammatory index and metabolic syndrome in Iranian population (Fasa Persian Cohort Study)

Dietary inflammatory potential in relation to the gut microbiome: results from a cross-sectional study

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