Dietary Inflammatory Index and Renal Cell Carcinoma Risk in an Italian Case–Control Study

Shivappa, Nitin; Hébert, James R.; Rosato, Valentina; Rossi, Marta; Montella, Maurizio; Serraino, Diego; Vecchia, Carlo La

doi:10.1080/01635581.2017.1339815

Cited by 11 publications

(8 citation statements)

References 46 publications

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“…This difference among studies may be the result of small sample sizes, study design or population substructure, or other factors. For kidney cancer, the pooled adjusted RR of kidney cancer for the highest DII score versus the lowest category was 1.46 (95% CI: 1.16–1.85), which is consistent with that in previous studies [ 24 , 27 ]. For bladder cancer and urothelial cell carcinoma, participants in the highest category of DII score were associated with an increased risk of bladder cancer (RR = 1.97, 95% CI: 1.28–3.03) compared with those in the lowest DII category [ 26 ].…”

Section: Discussionsupporting

confidence: 90%

Meta-analysis of the association between the inflammatory potential of diet and urologic cancer risk

Ren

Zhang

et al. 2018

PLoS ONE

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BackgroundThe inflammatory potential of diet has been shown to have an association with the risk of several cancer types, but the evidence is inconsistent regarding the related risk of urologic cancer (UC). Therefore, we conducted the present meta-analysis to investigate the association between the inflammatory potential of diet and UC.MethodsPubMed, Embase and Web of Science were searched up to July 31, 2018. Two reviewers independently selected the studies and extracted the data. The pooled risk ratio (RR) and its 95% confidence interval (CI) were calculated using the Stata12.0 software package.ResultsNine case-control studies and three cohort studies including 83,197 subjects met the inclusion criteria. The overall meta-analysis results showed that individuals with the highest category of DII (dietary inflammatory index) were associated with an increased risk of prostate cancer (RR = 1.62, 95% CI: 1.30–2.02); subgroup analysis showed consistent results. For kidney and bladder cancer, significant positive associations were found in individuals with the highest category of DII score; however, no significant association was found between DII and the risk of urothelial cell carcinoma (UCC).ConclusionAvailable data suggest that more pro-inflammatory diets are associated with an increased risk of prostate cancer, kidney cancer and bladder cancer. However, further well designed large-scaled cohort studies are warranted to provide more conclusive evidence.

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Section: Discussionsupporting

confidence: 90%

Meta-analysis of the association between the inflammatory potential of diet and urologic cancer risk

Ren

Zhang

et al. 2018

PLoS ONE

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“…Results of 16 other types of cancer are shown in Table 2. Significant positive associations were found in the analyses of pancreatic cancer (54,62), ovarian cancer (59,71), renal cell carcinoma (47,70), esophageal squamous cell carcinoma (67,80), and esophageal adenocarcinoma (58,63). With regard to 11 other cancer types for which only 1 study was available, significant positive associations were observed for bladder (69), gastric (65), laryngeal (72), nasopharyngeal (75), hepatocellular (66), and esophageal squamous cell (58) carcinomas and non-Hodgkin lymphoma (74) but not for urothelial cell carcinoma (43), endometrial cancer (76), lung cancer (46), and gastroesophageal junctional adenocarcinoma (58) ( Table 2).…”

Section: Other Types Of Cancersmentioning

confidence: 98%

Dietary Inflammatory Index and Site-Specific Cancer Risk: A Systematic Review and Dose-Response Meta-Analysis

Jayedi

Emadi

Shab‐Bidar

2018

Advances in Nutrition

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Existing evidence suggests a link between the inflammatory potential of diet and risk of cancer. This study aimed to test the linear and potential nonlinear dose-response associations of the Dietary Inflammatory Index (DII), as being representative of inflammatory features of the diet, and site-specific cancer risk. A systematic search was conducted with the use of PubMed and Scopus from 2014 to November 2017. Prospective cohort or case-control studies reporting the risk estimates of any cancer type for ≥3 categories of the DII were selected. Studies that reported the association between continuous DII score and cancer risk were also included. Pooled RRs were calculated by using a random-effects model. Eleven prospective cohort studies (total n = 1,187,474) with 28,614 incident cases and 29 case-control studies with 19,718 cases and 33,229 controls were identified. The pooled RRs for a 1-unit increment in the DII were as follows: colorectal cancer, 1.06 (95% CI: 1.04, 1.08; I2 = 72.5%; n = 9); breast cancer, 1.03 (95% CI: 1.00, 1.07; I2 = 84.0%; n = 7); prostate cancer, 1.06 (95% CI: 0.97, 1.15; I2 = 56.2%; n = 6); pancreatic cancer, 1.16 (95% CI: 1.05, 1.28; I2 = 61.6%; n = 2); ovarian cancer, 1.08 (95% CI: 1.03, 1.13; I2 = 0%; n = 2); esophageal squamous cell carcinoma, 1.24 (95% CI: 1.10, 1.38; I2 = 64.3%; n = 2); renal cell carcinoma, 1.08 (95% CI: 1.02, 1.13; I2 = 0%; n = 2); and esophageal adenocarcinoma, 1.26 (95% CI: 1.13, 1.39; I2 = 0%; n = 2). A nonlinear dose-response meta-analysis showed that, after a somewhat unchanged risk within initial scores of the DII, the risk of colorectal cancer increased linearly with increasing DII score. In the analyses of breast and prostate cancers, the risk increased with a very slight trend with increasing DII score. In conclusion, the results showed that dietary habits with high inflammatory features might increase the risk of site-specific cancers.

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“…We have also observed associations between the DII and urinary bladder cancer in analyses of data from elderly subjects in a pooled case-control in Italy (OR continuous = 1.08, 95% CI: 1.00–1.17); P trend = 0.003) [78] and in separate case-control studies in Italy (OR Quartile4vs1 = 1.97, 95% CI: 1.28–3.03; P trend = 0.003) [116] and Iran (OR above vs below median = 2.46; 95% CI = 1.12–5.41) [117]. Two studies on renal cancer, both showing positive results, have been conducted in a prospective study of women in Iowa in the USA (HR DIItertile3vs1 = 1.52; 95% CI: 1.09, 2.13) [118] and in an Italian case-control study (OR Quartile4vs1 = 1.41, 95% CI: 1.02–1.97; P trend = 0.04) [119].…”

Section: DII and Cancersmentioning

confidence: 99%

Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

et al. 2019

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There are over 1,000,000 publications on diet and health and over 480,000 references on inflammation in the National Library of Medicine database. In addition, there have now been over 30,000 peer-reviewed articles published on the relationship between diet, inflammation, and health outcomes. Based on this voluminous literature, it is now recognized that low-grade, chronic systemic inflammation is associated with most non-communicable diseases (NCDs), including diabetes, obesity, cardiovascular disease, cancers, respiratory and musculoskeletal disorders, as well as impaired neurodevelopment and adverse mental health outcomes. Dietary components modulate inflammatory status. In recent years, the Dietary Inflammatory Index (DII®), a literature-derived dietary index, was developed to characterize the inflammatory potential of habitual diet. Subsequently, a large and rapidly growing body of research investigating associations between dietary inflammatory potential, determined by the DII, and risk of a wide range of NCDs has emerged. In this narrative review, we examine the current state of the science regarding relationships between the DII and cancer, cardiometabolic, respiratory and musculoskeletal diseases, neurodevelopment, and adverse mental health outcomes. We synthesize the findings from recent studies, discuss potential underlying mechanisms, and look to the future regarding novel applications of the adult and children’s DII (C-DII) scores and new avenues of investigation in this field of nutritional research.

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Dietary Inflammatory Index and Renal Cell Carcinoma Risk in an Italian Case–Control Study

Cited by 11 publications

References 46 publications

Meta-analysis of the association between the inflammatory potential of diet and urologic cancer risk

Meta-analysis of the association between the inflammatory potential of diet and urologic cancer risk

Dietary Inflammatory Index and Site-Specific Cancer Risk: A Systematic Review and Dose-Response Meta-Analysis

Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

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