Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y

García-Calzón, Sonia; Zalba, Guillermo; Ruiz‐Canela, Miguel; Shivappa, Nitin; Hébert, James R.; Martínéz, J. Alfredo; Fitó, Montserrat; Gómez‐Gracia, Enrique; Martínez‐González, Miguel Ángel; Marti, Amelia

doi:10.3945/ajcn.115.116863

Cited by 117 publications

(112 citation statements)

References 53 publications

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“…Adherence to healthy dietary pattern like Mediterranean diet was also protective in this case-control study 37 . A diet with a high Mediterranean diet score (MDS), as defined by Trichopoulou et al 2003 38 , would also have a low DII (or E-DII) score as we have observed previously in other Mediterranean populations 39–41 . In this study, we observed an inverse Spearman correlation of −0.43 (p-value <0.0001).…”

Section: Discussionmentioning

confidence: 51%

Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy

et al. 2017

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Diet and inflammation have been suggested to be important risk factors for oral and pharyngeal cancer. We examined the association between dietary inflammatory index (DII) and oral and pharyngeal cancer in a large case-control study conducted between 1992 and 2009 in Italy. This study included 946 cases with incident, histologically confirmed oral and pharyngeal cancer, and 2492 controls hospitalized for acute non-neoplastic diseases. The DII was computed based on dietary intake assessed by a valid 78-item food frequency questionnaire and was adjusted for non-alcohol energy intake using the residual approach (E-DII). Logistic regression models were used to estimate odds ratios (ORs), and 95% confidence intervals (CIs), adjusted for age, sex, non-alcohol energy intake, study center, year of interview, education, body mass index, tobacco smoking, and alcohol drinking. Subjects with higher DII scores (i.e., with a more pro-inflammatory diet) had a higher risk of oral and pharyngeal cancer, the OR being 1.80 (95% CI 1.36–2.38) for the highest versus the lowest DII quartile and 1.17 (95 % CI 1.10–1.25) for a one-unit increase (8 % of the DII range). When stratified by selected covariates, a stronger association was observed among women (ORquartile4 v.1 3.30, 95% CI 1.95–5.57). We also observed stronger association for oral cancer subsite and a strong combined effect of higher DII and tobacco smoking or alcohol consumption on oral and pharyngeal cancer. These results indicate that the pro-inflammatory potential of the diet, as shown by higher DII scores, is associated with higher odds of oral and pharyngeal cancer.

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Section: Discussionmentioning

confidence: 51%

Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy

et al. 2017

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“…Cabe señalar que solo tres de los estudios con resultados significativos en relación con la asociación entre los patrones dietéticos y TL evaluaron la calidad de la dieta (147,156,164).…”

Section: Resultados Y Discusiónunclassified

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Marti¹,

Echeverría

Morell‐Azanza

et al. 2017

Nutr Hosp

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Palabras clave:Telómeros. Dieta mediterránea. Estrés oxidative. ADN. ResumenFundamento: existen pocos estudios que hayan evaluado la relación entre la calidad de la dieta y la integridad telómerica en humanos. Los telómeros son regiones de ADN no codificante que se encuentran en los extremos de los cromosomas, cuya longitud además de indicar la esperanza de vida, indica el estado global de salud. El objetivo de la presente revisión sistemática es recopilar la evidencia existente sobre la relación entre la longitud de los telómeros y la calidad de la dieta para conocer el impacto que algunos nutrientes, alimentos y patrones dietéticos pueden tener sobre la homeostasis telomérica y por lo tanto, sobre la salud en general. Material y métodos: se realizó una revisión bibliográfica en la base de datos PubMed para identificar los artículos publicados (en inglés o español) hasta diciembre de 2016 que cumplían los siguientes criterios: incluían sujetos humanos; eran estudios transversales; estudios de casos y controles; estudios de cohortes prospectivos o estudios de intervención; que evaluaban la relación de los nutrientes, alimentos o patrones dietéticos con la longitud de los telómeros. La estrategia de búsqueda incluía las siguientes palabras clave: nutrients or food OR food groups OR diet OR dietary pattern OR eating pattern OR dietary habits OR diet type AND telomere attrition OR telomere length. En total, se incluyeron 19 estudios transversales, cinco estudios de casos y controles, cinco estudios de cohortes prospectivos y dos estudios de intervención, incluyendo aquellos artículos que se encontraron por listas de referencias de otras publicaciones. Resultados: se encontraron asociaciones positivas entre la longitud de los telómeros y la adherencia a la dieta mediterránea y el consumo de verduras y frutas. Los resultados obtenidos para otros nutrientes, alimentos o patrones dietéticos fueron incoherentes, aunque parece que las carnes procesadas, los cereales, el alcohol y las bebidas endulzadas podrían estar asociados con telómeros más cortos. Conclusiones: la intervención dietética, y en particular la promoción de una dieta de estilo mediterráneo, podría desempeñar un papel en la protección de la integridad telomérica. Key words:Telomere. Mediterranean diet. Oxidative stress. DNA. AbstractBackground: Few studies have evaluated the relationship between diet quality and telomere integrity in humans. Telomeres are regions of non-coding DNA localized at the end of each chromosome whose length, in addition to indicating life expectancy, indicates an overall health status. The objective of this systematic review is to compile the existing evidence on the relationship between telomere length and diet quality to further explore the impact that some nutrients, foods and dietary patterns may have on telomere homeostasis and therefore, in precision nutrition strategies. Material and methods: A bibliographic review was performed in the PubMed database to identify published articles (in English or Spanish) until December 201...

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“…Further corroboration of the validation of the DII is that fact that it has been associated with a wide range of outcomes associated with inflammation. The DII was previously associated with several types of cancer (e.g., colorectal, prostate, pancreas, lung, esophageal) (6–12), cardiovascular disease (13), components of metabolic syndrome (5), telomere length (14), obesity (15), asthma (16), and mortality (17, 18). However, previous construct validation studies using inflammatory markers were mainly conducted among populations that were mainly European Americans.…”

Section: Introductionmentioning

confidence: 99%

Construct validation of the Dietary Inflammatory Index among African Americans

Wirth

Shivappa

Davis

et al. 2017

The Journal of nutrition, health and aging

110

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Objectives Chronic inflammation is linked to many chronic conditions. One of the strongest modulators of chronic inflammation is diet. The Dietary Inflammatory Index (DII) measures dietary inflammatory potential and has been validated previously, but not among African Americans (AAs). Design Cross-sectional analysis using baseline data from the Healthy Eating and Active Living in the Spirit (HEALS) intervention study. Setting Baseline data collection occurred between 2009 and 2012 in or near Columbia, SC. Participants African-American churchgoers Measurements Baseline data collection included c-reactive protein (CRP) and interleukin-6 from blood draws, anthropometric measures, and numerous questionnaires. The questionnaires included a food frequency questionnaire which was used for DII calculation. The main analyses were performed using quantile regression. Results Subjects in the highest DII quartile (i.e., more pro-inflammatory) were younger, more likely to be married, and had less education and greater BMI. Individuals in DII quartile 4 had statistically significantly greater CRP at the 75th and 90th percentiles of CRP versus those in quartile 1 (i.e., more anti-inflammatory). Conclusion Construct validation provides support for using the DII in research among AA populations. Future research should explore avenues to promote more anti-inflammatory diets, with use of the DII, among AA populations to reduce risk of chronic disease.

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Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y

Cited by 117 publications

References 53 publications

Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy

Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Construct validation of the Dietary Inflammatory Index among African Americans

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