Dietary Inflammatory Index and the Risk of Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents

Abstract

Background: Dietary Inflammatory Index (DII) scores have been consistently associated with several chronic diseases. This study explored the correlation between the DII and hyperuricemia in Chinese adult residents. Methods: The study included 7880 participants from the China Health and Nutrition Survey (CHNS), which was taken in in 2009. A 3-day 24 h meal review method was used to collect diet data and to calculate the DII score. Serum uric acid was obtained to determine hyperuricemia levels. Subjects were divided into a hyperuricemia group and a non-hyperuricemia group, according to their serum uric acid level. Multilevel logistic regression models were used to examine the association between DII scores and hyperuricemia. Results: After adjusting for covariates, a higher DII score was determined to be associated with a higher risk of hyperuricemia. Compared to those in the highest DII score group, the lower DII score group had an inverse association with hyperuricemia risk (Q2: 0.83, 95% CI: 0.70–0.99; Q3: 0.72, 95% CI: 0.60–0.86; Q4: 0.73, 95% CI: 0.61–0.88). The intake of energy-adjusted protein, total fat, MUFAs, PUFAs and saturated fatty acid was higher in the hyperuricemia group. Conclusions: A higher DII score is significantly associated with a higher risk of hyperuricemia. Controlling the intake of pro-inflammatory food may be beneficial to reduce the risk of hyperuricemia.

[Retracted] A Network Pharmacology Method Combined with Molecular Docking Verification to Explore the Therapeutic Mechanisms Underlying Simiao Pill Herbal Medicine against Hyperuricemia

“…Interestingly, some of these core targets were proinflammatory factors, such as TNF, IL6, and IL1B. Evidence has demonstrated that inflammation is significantly implicated in the pathogenesis of HUA [51][52][53]. Specifically, Nod-like receptor protein 3 (NLRP3) inflammasome is frequently activated during HUA, leading to the secretion of IL1B and other proinflammatory cytokines [52].…”

The association between Dietary Inflammatory Index and hyperuricemia: NHANES 2007–2016

“…Hye et al suggested that higher proin ammatory dietary score was linked to the increased odds of hyperuricemia, but the association was only signi cant among females [30]. Chen et al found that this association was signi cant in the whole population including men and women [31]. Similarly, our results on the association of DII and hyperuricemia remained signi cant among men and women after subgroup analyses.…”

The association between serum uric acid levels and the risk of cognitive dysfunction in patients with atrial fibrillation

“…In addition, myocardial infarction, heart failure, and elevated serum uric acid are associated with some common risk factors. For example, dyslipidemia, obesity, frequent consumption of fried foods, smoking, alcohol consumption [9][10][11][12][13][14]. Serum uric acid also interacts with multiple serum markers (creatinine, hemoglobin, platelets) as a dynamic oxidative stress indicator.…”