Dietary inflammatory potential and biological aging among US adults: a population-based study

Xie, Ruijie; Ning, Zhongxing; Xiao, Mengde; Li, Lihong; Liu, Mingjiang; Zhang, Ya

doi:10.1007/s40520-023-02410-1

Cited by 36 publications

(19 citation statements)

References 57 publications

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“…The nonlinear relationship between flavonoid intake and DII was assessed using a smoothed curve fit (penalized spline method) and a generalized additive model, the recursive algorithm was used to calculate the inflection points between flavonoids intake and DII, and a 2-segment linear model was used on both sides of the inflection point to investigate the association between flavonoids intake and DII. [25][26][27] A 2-tailed P value < .05 was considered statistically significant. Analyses were performed with R (version 4.2) and Empower Stats (http://www.…”

Section: Discussionmentioning

confidence: 99%

Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES

Wan,

Huang,

et al. 2023

Medicine

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Flavonoids have been shown to be beneficial in a variety of inflammatory and metabolic diseases because of their anti-inflammatory and antioxidant properties. However, previous epidemiological studies have only demonstrated a negative correlation between flavonoid intake on inflammatory markers, and the optimal intake of dietary flavonoids and subclasses in terms of dietary anti-inflammatory efficacy remains undetermined. This study was based on 3 cycles (2007–2010, 2017–2018) of the National Health and Nutrition Examination Survey and the corresponding expanded flavonoid database. Weighted multiple linear regression was used to assess linear relationships between flavonoid intake and Dietary inflammation index (DII). Smoothed curve fit and a generalized additive model were used to investigate the nonlinear relationships and threshold effects, the 2-tailed linear regression model was used to find potential inflection points. A total of 12,724 adults were included in the study. After adjusting for potential confounders, flavonoid intake was significantly associated with DII, with the strongest negative association effect for flavonols (−0.40 [−0.45, −0.35]). In subgroup analyses stratified by sex, race, age, body mass index, education levels, and diabetes, flavonol intake maintained a significant negative linear correlation with DII. In addition, we found significant nonlinear relationships (L-shaped relationships) and threshold effects between total flavonoids, flavan-3-ols, and flavanols and DII, with inflection points of 437.65 mg/days, 157.79 mg/days, and 46.36 mg/days, respectively. Our results suggest a threshold for the dietary anti-inflammatory capacity of flavonoid intake in U.S. adults.

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Section: Discussionmentioning

confidence: 99%

Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES

Wan,

Huang,

et al. 2023

Medicine

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“…Nonlinear relationships were evaluated using smoothed curve fits and generalized additive models. [20][21][22] Statistical significance was determined using a 2-tailed P value < .05. In the subgroup analysis stratified by gender or race, the model is not adjusted for the stratification variable itself.…”

Section: Discussionmentioning

confidence: 99%

Association between urine caffeine metabolites and bone mineral density: A population-based study

Tan,

Shen,

Tang

et al. 2023

Medicine

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The association between coffee intake and bone mineral density (BMD) remains a subject of debate in epidemiological research. Furthermore, the potential relationship between BMD and urine caffeine or caffeine metabolites has not yet been explored. Therefore, the present study aimed to investigate the possible association between BMD and urine caffeine and its metabolites in U.S. adults. We employed multivariate linear and logistic regression models to analyze the relationship between urine caffeine and caffeine metabolites and lumbar BMD using data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2014. Additionally, fitted smoothing curves and generalized additive models were used. After adjusting for several factors, we found no significant association between urine caffeine and its metabolites and BMD. However, subgroup analyses stratified by gender and ethnicity showed that the relationship between urine caffeine and its metabolites and lumbar BMD remained consistent. Our investigation revealed that the inflection points for the U-shaped relationship between urinary theophylline and paraxanthine and BMD were observed at levels of 0.006 mmol/L for theophylline and 0.052 mmol/L for paraxanthine. In this cross-sectional study, we found no significant correlation between urine caffeine and its metabolites and BMD. However, more research is required to confirm our findings, as well as to investigate the underlying mechanisms.

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“…In addition, multinomial logistic regression model was used to investigate the association between CAP and GOLD-graded COPD. To investigate the nonlinear association between COPD with CAP and LSM, we used restricted cubic spline (RCS) curve 29 , 30 . We established statistical significance at two-sided P < 0.05 22 , 24 .…”

Section: Methodsmentioning

confidence: 99%

Association of hepatic steatosis and liver fibrosis with chronic obstructive pulmonary disease among adults

Zheng,

Liu,

Zeng

et al. 2024

Sci Rep

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With high prevalence and substantial mortality, metabolic dysfunction-associated steatotic liver disease and chronic obstructive pulmonary disease (COPD) are significant public health concerns. Utilizing a large, population-based dataset from the National Health and Nutrition Examination Survey, our study probes the relationship between COPD prevalence and hepatic steatosis and fibrosis, as measured by Vibration-Controlled Transient Elastography. We analyzed data from 693 individuals with COPD and 7229 without. Through weighted multivariate logistic regression analysis, a restricted cubic spline curve, and threshold effect analysis, we investigated the correlation between the severity of hepatic steatosis and fibrosis and the presence of COPD. Our findings revealed a positive correlation between the controlled attenuation parameter (CAP) and COPD prevalence [OR = 1.03 (95% CI 1.01, 1.05)], even after multivariate adjustment. Furthermore, we observed a U-shaped association between CAP and COPD, where the inflection point, CAP value of 264.85 dB/m, corresponded to the lowest COPD prevalence. Our study emphasizes a substantial and complex link between hepatic steatosis and COPD. These findings urge healthcare professionals to factor liver health into COPD management and prompt further exploration into the underlying mechanisms. This could pave the way for the development of improved prevention and treatment strategies.

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Dietary inflammatory potential and biological aging among US adults: a population-based study

Cited by 36 publications

References 57 publications

Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES

Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES

Association between urine caffeine metabolites and bone mineral density: A population-based study

Association of hepatic steatosis and liver fibrosis with chronic obstructive pulmonary disease among adults

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