Dietary influences on intestinal immunity

Veldhoen, Marc; Brucklacher-Waldert, Verena

doi:10.1038/nri3299

Cited by 143 publications

(110 citation statements)

References 122 publications

(154 reference statements)

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“…Plantand fish-based diets typically yield polyunsaturated fatty acids, while a Western diet rich in red meat and fried foods is a source of saturated fatty acids. In general, saturated fatty acids induce inflammatory activation of immune cells, while polyunsaturated fats can give rise to both inflammatory and antiinflammatory functions (43). For instance, saturated fatty acids activate TLR2 and TLR4 signaling in macrophages to promote inflammatory cytokine release (44), while the omega-3 polyunsaturated fatty acids bind the GPCR GPR120 to reduce inflammatory activity (45).…”

Section: Microbial and Dietary Influences On Intestinal Immunitymentioning

confidence: 99%

Immunologic impact of the intestine in metabolic disease

Winer¹,

Winer²,

Dranse³

et al. 2017

Journal of Clinical Investigation

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Section: Microbial and Dietary Influences On Intestinal Immunitymentioning

confidence: 99%

Immunologic impact of the intestine in metabolic disease

Winer¹,

Winer²,

Dranse³

et al. 2017

Journal of Clinical Investigation

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“…Diet affects the composition of the gut microbiota and thereby maintenance of immune tolerance, but can modulate immunity via direct effects on immune cells as well (55,56). Altered or poor microbiota, dysbiosis, contributes to compromised epithelial integrity and disrupted tolerance (57,58).…”

Section: Dietary Factorsmentioning

confidence: 99%

Helsinki alert of biodiversity and health

et al. 2015

Self Cite

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Urban living in built environments, combined with the use of processed water and food, may not provide the microbial stimulation necessary for a balanced development of immune function. Many chronic inflammatory disorders, including allergic, autoimmune, metabolic, and even some behavioural disorders, are linked to alteration in the human commensal microbiota. Sedentary lifestyle is associated with reduced exposure to a broad spectrum of environmental micro-organisms and surplus energy balance, both risk factors of chronic inflammatory disorders. According to the Biodiversity Hypothesis, an environment with diverse macrobiota and microbiota modifies and enriches the human microbiota, which in turn is crucial in the development and maintenance of appropriate immune function. These issues were discussed in the symposium Chronic Inflammation, Lifestyle and Environment , held in Helsinki, 20 - 22 August 2014, under the sponsorship of the Yrjo Jahnsson Foundation. This paper briefly outlines the recent findings in the context of the environment, lifestyle, and health; discusses the forces that undermine immune tolerance in urban environments; and highlights the possibilities to restore broken immune tolerance among urban dwellers, summarizing the main messages in four statements and calling for actions to combat major public health threats

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“…Indeed, immunologic outcomes appear to be linked to the nature of the infectious agents (Yazdanbakhsh et al, 2002;Bach, 2005;Christen and von Herrath, 2005;Kamradt et al, 2005;Kivity et al, 2009;Macia et al, 2012). Diet also affects the immune response and the development of inflammation (Mora et al, 2008;Veldhoen and Brucklacher-Waldert, 2012). Finally, additional factors such as environmental pollutants and ultraviolet light have significant effects on experimental models of autoimmunity and have been linked to human inflammatory disorders (Rook, 2011;Halliday et al, 2012).…”

Section: Introductionmentioning

confidence: 99%