Dietary inhibitors of mutagenesis and carcinogenesis

Hayatsu, Hikoya; Arimoto, Sakae; Negishi, Tomoe

doi:10.1016/0027-5107(88)90204-7

Cited by 284 publications

(83 citation statements)

References 97 publications

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“…Moreover, the results obtained with the three forms of treatment did not Guterres et al 461 differ enough to suggest the exact mechanism action in the protection against MMS. Apparently, in this case, both mechanisms are present, as previously suggested by Hayatsu et al (1988) and Sasaki et al (1994).…”

Section: Discussionsupporting

confidence: 66%

“…The antimutagenic effect of A. blazei extracts was also studied by the Ames assay, against the mutagen benzo(a)pyrene, when linoleic acid (an unsaturated fatty acid that represents 70-78% of total lipids of its fruiting body) isolated from A. blazei with chloroform:methanol (2:1), was associated with this effect in Salmonella (Osaki et al, 1994).The antimutagenicity of fatty acids is believed to involve not only antimutagenic mechanisms (through micelle formation around the mutagen) but also bioantimutagenic mechanisms (improving repair processes in the cell) (Hayatsu et al, 1988;Sasaki et al, 1994). This compound was first shown to prevent mammary carcinogenesis in murine models.…”

Section: Introductionmentioning

confidence: 99%

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Genotoxic and antigenotoxic effects of organic extracts of mushroom Agaricus blazei Murrill on V79 cells

et al. 2005

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Agaricus blazei Murrill, popularly known as the sun mushroom, is a native mushroom in SP, Brazil, that has been widely used in the treatment of cancer and many other pathologies in different parts of the world. A water-soluble protein-polysaccharide complex (1 ® 6)b-D-glucan has been isolated from its fruiting body that showed immune-modulation activity. From organic extracts, linoleic acid has been isolated and determined to be the main substance with antimutagenic activity. Using both the micronucleus (MN) and comet (single cell microgel electrophoresis) assays, this study determined the genotoxic and antigenotoxic potential of A. blazei (AB) obtained from commercial sources or the following strains: a) strains AB 97/29 (young and sporulated phases); b) a mixture taken from AB 96/07, AB 96/09 and AB 97/11 strains; and c) commercial mushrooms from Londrina, PR and Piedade, SP, designated as AB PR and AB SP, respectively. The extracts from these mushrooms were isolated in chloroform:methanol (3:1) and used in vitro at three different concentrations. V79 cells (Chinese hamster lung cells) were exposed to the extracts under pre-, simultaneous and post-treatment conditions, combined with methyl methanesulfonate (MMS). Under the circumstances of this study, these organic extracts did not show any genotoxic or mutagenic effects, but did protect cells against the induction of micronuclei by MMS.

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Genotoxic and antigenotoxic effects of organic extracts of mushroom Agaricus blazei Murrill on V79 cells

et al. 2005

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“…The majority of such substances have in addition anti-oxidative and antiinflammatory effects and can be applied, consequently; as effective chemopreventive or chemoprotective agents. While mutagenic and co-mutagenic substances may occur in foodstuffs as well as in the ambient air, antimutagens can act only through their intake in foodstuffs (HAYATSU et al 1988).…”

mentioning

confidence: 99%

Antimutagenic effect of ellagic acid and its effect on the immune response in mice

Smerak¹,

Sestakova²,

Polívková³

et al. 2002

Czech J. Food Sci.

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Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of ellagic acid on the genotoxicity of three mutagens: amino-methylimidazo-quinoline (IQ), aflatoxin B1 (AFB1), and N-nitroso-N-methylurea (MNU). Ellagic acid is a naturally occurring phenolic compound which is found in a variety of soft fruits and vegetables. The effect of this compound on the immunosuppressive activity of mutagens was followed in vivo by the chemiluminescence test. In the Ames assay, ellagic acid at concentrations of 300 and 30 μg/plate demonstrably inhibits the mutagenic activity of two indirect mutagens: IQ and AFB1. The concentration of 300 μg/plate had the strongest effect on mutagenicity of all concentrations of IQ in strain TA98 of Salmonella typhimurium, whereas in strain TA100 concentration of 30 μg per dish of ellagic acid was more effective than 300 μg per plate. Also in combination with different concentrations of AFB1, ellagic acid proved to be a strong antimutagen. In this case the lower of the two effective concentrations – 30 μg/plate – had a much greater antimutagenic effect on both strains tested than 300 μg/plate. In combination with the direct mutagen MNU, ellagic acid did not show any marked antimutagenic effect at most of the concentrations tested in strain TA100. Only the highest concentrations of ellagic acid reduced the mutagenic effect of MNU weakly and only in combination with two lower concentrations of MNU. In the micronucleus test, three-day oral application of ellagic acid prior to the applicaton of AFB1, IQ, or MNU, respectively, markedly reduced the numbers of micronuclei induced by these three mutagens in polychromatophilic erythrocytes of mice. Chemiluminescence test with mouse granulocytes proved that ellagic acid not only prevents the inhibitory effects of mutagens on free oxygen radicals and hydrogen peroxide production, but that this production is stimulated by ellagic acid in combination with mutagens even to a greater extent than by ellagic acid alone. From these results we can deduce that ellagic acid repairs strong immunosuppressive effects of all mutagens applied.  

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“…It has been reported that many kinds of vegetables, fruits and cereals have antimutagenicity (Morita et a/., 1978;Edenharder et a/., 1995), and that their fibers, high-molecule substances, have anticarcinogenicity by adsorbing carcinogens from various sources (Burkitt, 197 1 ;Barbolt & Abraham, 1978;Barnes et a/., 1983;Kada et a/., 1984;Takeuchi et al, 1988;Hayatsu et a/., 1988). Okabe et a/.…”

mentioning

confidence: 99%

Suppressive Effects of Polysaccharide Produced by Bacillus circulans on Chemical Mutagens-Induced SOS Response in Salmonella typhimurium.

Isobe

Yokoigawa

Kawai

1998

FSTI

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The suppressing effects of polysaccharide produced by Bacillus circulans on the SOS response of Salmonella typhimurium TA 1535/pSKIOO2 induced by AF-2, MNNG, 4NQO, Trp-P-2, IQ and MelQx were compared with those of commercial polysaccharides to find a new physiological value as an additive to processed foodstuffs. The native polysaccharide produced by B. circulans strongly suppressed SOS response induced by IQ and MelQx, and the suppression was increased with increasing polysaccharide concentration. Xanthan gum, which is an acidic polysaccharide produced by Xanthomonas campestris, and carboxymethyl cellulose (CMC) did not suppress SOS response induced by nnutagens.

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Dietary inhibitors of mutagenesis and carcinogenesis

Cited by 284 publications

References 97 publications

Genotoxic and antigenotoxic effects of organic extracts of mushroom Agaricus blazei Murrill on V79 cells

Genotoxic and antigenotoxic effects of organic extracts of mushroom Agaricus blazei Murrill on V79 cells

Antimutagenic effect of ellagic acid and its effect on the immune response in mice

Suppressive Effects of Polysaccharide Produced by Bacillus circulans on Chemical Mutagens-Induced SOS Response in Salmonella typhimurium.

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