Dietary intake of cadmium, chromium, copper, manganese, selenium and zinc in a Northern Italy community

Filippini, Tommaso; Cilloni, Silvia; Malavolti, Marcella; Violi, Federica; Malagoli, Carlotta; Tesauro, M.; Bottecchi, Ilaria; Ferrari, Ângela; Vescovi, Luciano; Vinceti, Marco

doi:10.1016/j.jtemb.2018.03.001

Cited by 133 publications

(89 citation statements)

References 123 publications

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“…All these factors will have resulted in some unquantifiable misclassification of exposure. It is noteworthy however that our estimates of daily cadmium intake were closely similar to those estimated by other Italian studies while the ranking of cadmium sources (cereals > vegetables > sweets > fish/seafood) was the same as that found in other Italian, and European studies…”

Section: Discussionsupporting

confidence: 90%

“…Mean intake of cadmium from the diet in our cohort was 0.89 (SD 0.31) μg/week/kg body weight, which is well below the intake limit of 7 μg/week/kg considered safe by the WHO . The daily mean intake of dietary cadmium was 7.8 μg (standard deviation, SD, 1.4), which is similar to the intake reported in a recent study in a Northern Italy community (median 5.0 μg/day, interquartile range 3.17–7.65) …”

Section: Discussionsupporting

confidence: 85%

“…Furthermore breast cancer cases were identified by the local cancer registry, and it is unlikely that any cases were lost . Other strengths are the large number of food samples used for the analytical determinations of cadmium, collected from local groceries and supermarkets in order to mimic the real sources of foodstuffs in the population …”

Section: Discussionmentioning

confidence: 99%

“…Cadmium levels in foods were determined by inductively coupled plasma mass spectrometry after wet‐ashing with 50% aqueous nitric acid in a microwave digestion system. Quantification limit was 0.02 μg/kg, and detection limit was 0.007 μg/kg . The cadmium levels thus obtained were added to the Italian food composition tables to thereby afford estimates of dietary cadmium intake (μg/day) for each participant.…”

Section: Methodsmentioning

confidence: 99%

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Dietary cadmium and risk of breast cancer subtypes defined by hormone receptor status: A prospective cohort study

Grioni

Agnoli

Krogh

et al. 2019

Intl Journal of Cancer

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Diet is the primary source of cadmium-a proven Group 1 human carcinogen-for non-smokers. Observational studies investigating the effect of cadmium from food sources on breast cancer risk have produced inconsistent results. We examined the association between dietary cadmium and risk of breast cancer defined by estrogen receptor (ER), progesterone receptor (PR) and HER2 status, in 8924 women recruited to a prospective study between 1987 and 1992. Dietary cadmium intake was estimated using a semi-quantitative food frequency questionnaire at baseline. During a median of 22 years of follow-up, 451 incident cases of breast cancer were identified through the Varese Cancer Registry. Multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for breast cancer and receptor-defined breast cancer subtypes were estimated for quintiles of dietary cadmium intake, adjusting for confounding factors. Mean dietary cadmium intake was 7.8 (standard deviation 1.4) μg/day. Women with highest quintile of cadmium intake had a greater risk of breast cancer (HR 1.54; 95% CI, 1.06-2.22; p trend = 0.028) than those with lowest quintile of intake. Women premenopausal at recruitment had HR = 1.73 (95% CI, 1.10-2.71, highest vs. lowest quintile); postmenopausal women had HR = 1.32 (95% CI, 1.05-1.66 for each standard deviation increase in cadmium). Cadmium-related risk of breast cancer did not vary with ER, PR or HER2 status (p-heterogeneity not significant). These findings support the hypothesis that dietary cadmium is a risk factor for breast cancer.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Dietary cadmium and risk of breast cancer subtypes defined by hormone receptor status: A prospective cohort study

Grioni

Agnoli

Krogh

et al. 2019

Intl Journal of Cancer

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“…Cadmium (Cd) is a heavy metal, globally spread environmental toxicant due to its varied industrial applications [17]. Apart from the occupational exposure of workers; diet is generally recognized as being the main source of exposure to trace elements [15]. In its latest report, WHO established a provisional tolerable monthly intake for cadmium of 25 µg/kg body weight.…”

Section: Introductionmentioning

confidence: 99%

The potential gonadoprotective effects of grape seed extract against the histopathological alterations elicited in an animal model of cadmium-induced testicular toxicity

2020

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Background: Grape seed extract (GSE) is a powerful antioxidant containing high levels of bioflavonoids, vitamin C and vitamin E. The aim of the work is to study the possible protective and ameliorative effects of grape seed extract in an animal model of cadmium (Cd)-induced testicular toxicity in rats. Materials and Methods:A thirty-day oral gavage study in adult male albino rats was performed using 32 animals, randomly divided into 4 equal groups; negative control, cadmium (5 mg/k/day), grape seed extract (100 mg/k/day), and cadmium + GSE. Testicular weights were measured. Hematoxylin & eosin (H&E) staining and proliferating nuclear cell antigen (PCNA) immunohistochemistry, as a marker for proliferation were done. Morphometric parameters were assessed and subjected to statistical analysis. 2 Results: The H&E results showed atrophy and distortion of the seminiferous tubules (STs) with sloughing of the spermatogenic epithelium in cadmium group. The interstitial spaces were widened and showed edema and mononuclear cell infiltrations. No remarkable changes were observed in the grape-seed-only group when compared to the control group. In both combined group, maintaining of the STs and their lining cells was evident. The immunohistochemical results showed marked positive PCNA immunoreactivity in both control and GSE groups, while negative immunoreaction was noticed in Cd group. Limited positive PCNA immunoreactivity was ameliorated in Cd+ GSE group. Conclusions: GSE protected against cadmium-induced testicular toxicity in rats, reducing induced histopathological changes, and maintaining testicular histoarchitecture.National Institutes of Health [9]. Whenever possible, the procedures in the current study were conducted to avoid or minimize suffering, distress, and pain to animals. DrugsCadmium, in the form of cadmium chloride (CdCl2, 96% pure), was purchased from Sigma-Aldrich Corporation of industrial chemistry and biotechnology (St. Louis, Missouri, USA). Grape seed extract was purchased from herbal and medicinal plant store, Benha governorate, Egypt. The drugs were dissolved in normal saline. Experimental designThe rats were randomly divided into four groups, eight rats each: -Group 1: Negative control group (normal saline was given daily for 30 days by gastric gavage)Group 2: The animals were given grape seed extract (100 mg/kg/d) dissolved in normal saline for 30 days by gastric gavage [32]. A concentration of 100 mg was dissolved in 10 ml normal saline and shook to obtain a solution of 10 mg/ml. Group 3:The animals were given cadmium (5mg/kg/d) dissolved in normal saline for 30 days by gastric gavage [14]. A concentration of 5mg was dissolved in 10 ml normal saline and shook to obtain a solution of 0.5 mg/ml. Group 4:The animals were given cadmium (5mg/kg/d) + grape seed extract (100 mg/kg/d) for 30 days by gastric gavage.In order to avoid possible drug interactions and drug absorption, the drugs were given in the same time of the day, in two different time intervals. Cadmium was given in the morning (10 AM) whil...

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Essential and Nonessential Elements, Lipids and Volatile Compounds in Coffee and Transfer to Coffee Brews: Assessment of the Benefits and Potential Risks for Human Health

Senila,

Kovacs,

Senila

2024

Food Science & Nutrition

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Coffee is a popular beverage with significant commercial and social importance. The study aimed to determine the fatty acids profile, volatile compounds, and concentration of major and trace elements (Na, Mg, K, Ca, P, S, Fe, Mn, Cu, Zn, Cr, Ni, Cd, and Pb) in the two most important varieties of coffee, namely arabica and robusta. The leaching percentages of mineral elements and the effect of boiling time on the transfer of elements to aqueous extracts were also determined. In terms of fatty acids profile, the robusta variety was found to have a higher content of saturated fatty acids (46.68%) compared to the arabica variety (44.38%), whereas arabica contained a higher amount of omega‐6. Regarding the volatile compounds, arabica contained higher amounts of pyrazines (36%), ketones (5.4%), and furans (37.8%). The average contents of the major elements in roasted coffee (arabica and robusta) decreased in the order K > P > S > Mg > Ca > Na, while the trace elements content exhibited a decrease in the order Fe > Mn > B > Cu > Zn > Ni > Pb > Cd ≈ Cr. In coffee brews, the contents of elements have a similar decreasing trend, although variations in leaching percentages were observed. The health risk was assessed considering the concentrations of potentially toxic elements in coffee brews, and no health risks were indicated by the obtained scores. The contribution of coffee brews to the recommended dietary daily intake of essential elements is low. However, it can be significant considering that this beverage is consumed on a daily basis.

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Dietary intake of cadmium, chromium, copper, manganese, selenium and zinc in a Northern Italy community

Cited by 133 publications

References 123 publications

Dietary cadmium and risk of breast cancer subtypes defined by hormone receptor status: A prospective cohort study

Dietary cadmium and risk of breast cancer subtypes defined by hormone receptor status: A prospective cohort study

The potential gonadoprotective effects of grape seed extract against the histopathological alterations elicited in an animal model of cadmium-induced testicular toxicity

Essential and Nonessential Elements, Lipids and Volatile Compounds in Coffee and Transfer to Coffee Brews: Assessment of the Benefits and Potential Risks for Human Health

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