Dietary intake of different ratios of ARA/DHA in early stages and its impact on infant development

Fan, Lijiao; Wang, Xincen; Szeto, Ignatius Man-Yau; Liu, Biao; Sinclair, Andrew J.; Li, Duo

doi:10.1039/d3fo04629j

Cited by 1 publication

(1 citation statement)

References 102 publications

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“…The balance between ARA and DHA could play a crucial role in influencing cognitive and developmental outcomes during infancy and early childhood. Research on the neurodevelopment of infants who were fed formulas with varying ARA to DHA ratios suggests that the specific ratio utilized may have a substantial impact on the benefits of LC-PUFAs in early childhood, with neurodevelopmental outcomes showing preference for an ARA/DHA ratio of 1:1 or 2:1 ( 29 ). Notably, during the initial stages of this clinical trial, researchers meticulously considered the ARA to DHA ratio in the formula design, ultimately settling on a ratio of approximately 1.7.…”

Section: Discussionmentioning

confidence: 99%

A combination of phospholipids and long chain polyunsaturated fatty acids supports neurodevelopmental outcomes in infants: a randomized, double-blind, controlled clinical trial

Ren,

Zhu,

Pan

et al. 2024

Front. Nutr.

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Phospholipids (PLs) and long-chain polyunsaturated fatty acids (LCPUFAs) are naturally present in breast milk and play important roles in promoting the growth of the infant. Several studies have investigated the effects of the combination of PLs and LCPUFAs on neurodevelopment. However, data on the effectiveness of infant formula containing both PLs and LCPUFAs on the neurodevelopment of infants is still scarce. This randomized, double-blind, controlled clinical study was designed to evaluate the effect of an infant formula enriched with PLs and LCPUFAs on growth parameters and neurodevelopmental outcomes in term infants up to 365 days of age. Infants were enrolled within 30 days of birth who were then randomly assigned to either a control group (n = 150) or an investigational group (n = 150). Both groups consist of cow’s milk-based formula which were generally identical in terms of composition, except that the investigational formula was additionally supplemented with PLs and LCPUFAs. The infants were followed for the first year of life. Breastfed infants were the reference (n = 150). Bayley Scales of Infant Development [3rd edition (Bayley-III)], Carey Toddler Temperament Scales (TTS), MacArthur-Bates Communicative Development Inventories (CDI), Single Object Attention and Free Play Tasks were used to evaluate neurodevelopmental outcomes of infant at 365 days of age. In addition, Ages and Stages Questionnaires (ASQ) were also conducted at 120, 180, and 275 days of age. Compared to breastfeeding, both infant formulas were well-tolerated and provided adequate growth, with no adverse events being reported throughout the study. Infants of the investigational group showed higher mean scores in Bayley-III cognitive performance (104.3 vs. 99.0, p < 0.05), language (106.9 vs. 104.5, p < 0.05), and motor skills (109.2 vs. 103.9, p < 0.05) compared the control group. Similar results were being reported for other developmental scales including TTS and ASQ. Notably, the test scores of infants fed the investigational formula were similar to those who were breastfed. Our results indicate that PL and LCPUFA supplementation may be beneficial for neurodevelopment of infants throughout the first year of life. Further studies are needed to investigation long-term effects PL and LCPUFA on neurodevelopment in early life.

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Section: Discussionmentioning

confidence: 99%

A combination of phospholipids and long chain polyunsaturated fatty acids supports neurodevelopmental outcomes in infants: a randomized, double-blind, controlled clinical trial

Ren,

Zhu,

Pan

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

show abstract

Dietary intake of different ratios of ARA/DHA in early stages and its impact on infant development

Abstract: Long-chain polyunsaturated fatty acids (LC-PUFAs) arachidonic acid (ARA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3) are essential in the development of infants. ARA and DHA from breast milk or infant formula...

Cited by 1 publication

References 102 publications

A combination of phospholipids and long chain polyunsaturated fatty acids supports neurodevelopmental outcomes in infants: a randomized, double-blind, controlled clinical trial

A combination of phospholipids and long chain polyunsaturated fatty acids supports neurodevelopmental outcomes in infants: a randomized, double-blind, controlled clinical trial

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