Dietary Intake of Fiber and Decreased Risk of Cancers of the Colon and Rectum: Evidence From the Combined Analysis of 13 Case-Control Studies

Howe, Geoffrey R.; Benito, E.; Castelleto, R; Cornée, Jacqueline; Estève, Jacques; Gallagher, Richard P.; Iscovich, José; Deng-ao, Jiao; Kaaks, Rudolf; Kune, Gabriel A.; Kune, Susan; L'Abbé, Kristan A.; Lee, Hin P.; Lee, Marion; Miller, Anthony B.; Peters, Ruth; Potter, John D.; Riboli, Elio; Slattery, Martha L.; Trichopoulos, Dimitrios; Tuyns, A; Τζώνου, Αναστασία; Whittemore, Alice S.; Wu‐Williams, Anna H.; Zheng, Shu

doi:10.1093/jnci/84.24.1887

Cited by 432 publications

(186 citation statements)

References 32 publications

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“…Fiber intakes (total, water-soluble, and waterinsoluble) have been reported to be inversely associated with the risk of colorectal cancer. 28 To examine whether the positive association for the Western dietary pattern was mediated by these nutrients, we included fiber intakes in the multivariate model. Further adjustment for fiber intakes did not alter this positive association for the Western dietary pattern score of females substantially: the RR for the comparison of the highest with the lowest quartile was 3.60 (95% CI ¼ 1.29-10.1) in distal colon.…”

Section: Resultsmentioning

confidence: 99%

Dietary patterns and subsequent colorectal cancer risk by subsite: A prospective cohort study

Kim

Sasaki

Otani³

et al. 2005

Intl Journal of Cancer

100

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In order to investigate the associations between dietary patterns and the risk of colorectal cancer by subsite in Japan, the baseline data from a population-based cohort study of 20,300 men and 21,812 women were analyzed. We conducted factor analysis and identified 3 major dietary patterns, ''healthy,'' ''traditional'' and ''Western,'' and calculated the factor scores of each pattern for individuals. During 10 years of follow-up, 370 colorectal cancer cases were identified. We found a positive association between the traditional pattern and colon cancer risk in women [rate ratio for highest quartile (RR) = 2.06; 95% CI = 1.10-3.84; p for trend = 0.11], but not in men. This positive association was slightly stronger for proximal colon cancer (RR = 2.07; 95% CI = 0.84-5.12) than for distal colon cancer (RR = 1.84; 95% CI = 0.75-4.50). After multivariate adjustment, the Western dietary pattern was also positively associated with colon cancer risk in females (RR = 2.21; 95% CI = 1.10-4.45), with the strongest associations being observed for females with distal colon cancer (RR = 3.48; 95% CI = 1.25-9.65). We did not observe any significant association between the healthy dietary pattern and colon cancer risk. For rectal cancer, no significant associations were found for the 3 dietary patterns. In conclusion, we found that the traditional and the Western dietary patterns were positively associated with colon cancer risk in females. ' 2005 Wiley-Liss, Inc.

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Section: Resultsmentioning

confidence: 99%

Dietary patterns and subsequent colorectal cancer risk by subsite: A prospective cohort study

Kim

Sasaki

Otani³

et al. 2005

Intl Journal of Cancer

100

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“…Epidemiological studies have suggested that a diet low in fat and high in fibre could be protective against colorectal cancer (Burkitt, 1971;Howe et al, 1992). Conversely, studies by Sandler et al (1993) have demonstrated that diets high in fat and low in fibre typical of those found in industrialised countries, increase the risk of the development of colon cancer.…”

Section: Introductionmentioning

confidence: 99%

Butyrate- but not TGFβ1-induced apoptosis of colorectal adenoma cells is associated with increased expression of the differentiation markers E-cadherin and alkaline phosphatase

1997

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Sodium butyrate and transforming growth factor b (TGFb 1 ) are growth inhibitory to colonic adenoma cell lines. Butyrate induces apoptosis, whereas in some adenoma cell lines, TGFb 1 can be growth inhibitory without apoptosis. In this report, we show that the adenoma cell line PC/BH/C1 undergoes apoptosis in response to TGFb 1 . Butyrate induced cell death is preceded by the induction of two markers of colonic differentiation ± alkaline phosphatase (ALP) activity and E-cadherin protein expression. However, TGFb 1 -induced apoptosis was not accompanied by induction of these differentiation markers. It is possible that the apoptosis induced by TGFb 1 in the adenoma cell line PC/BH/C1 is due to conflicting signals, as downregulation of c-myc protein in response to TGFb 1 occurs only slowly in this cell line. Development of resistance to TGFb 1 in colonic tumours may involve two separate stages ± resistance to growth inhibition and resistance to TGFb 1 -induced apoptosis. Our results indicate that sodium butyrate induces apoptosis via differentiation, but TGFb 1 induces apoptosis by a differentiationindependent mechanism. As for butyrate, the induction of Ecadherin expression is a potentially important chemopreventative action, since increased E-cadherin expression has been correlated with decreased metastatic potential. This is the first report of induction of E-cadherin by a naturally occurring factor in the diet. Butyrate may reduce tumour growth and invasion, not only as a result of the induction of apoptosis, but also through increased expression of E-cadherin.

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“…Many compounds have been shown to be efficient for carcinogenesis prevention in animal models and humans as well. Several studies suggest that natural polyphenol compounds have a great effect on cancer protection (Howe et al., 1992). These compounds that are secondary metabolites in plants and polyphenol diet have shown promising against cancer (Lall, Syed, Adhami, Khan, & Mukhtar, 2015).…”

Section: Resveratrol and Diseasesmentioning

confidence: 99%

Resveratrol: A miraculous natural compound for diseases treatment

Koushki

Amiri-Dashatan

Ahmadi

et al. 2018

Food Science & Nutrition

210

109

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Resveratrol (3, 5, 4′‐trihydroxystilbene) is a nonflavonoid polyphenol that naturally occurs as phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, and peanut. This compound has critical roles in human health and is well known for its diverse biological activities such as antioxidant and anti‐inflammatory properties. Nowadays, due to rising incidence of different diseases such as cancer and diabetes, efforts to find novel and effective disease‐protective agents have led to the identification of plant‐derived compounds such as resveratrol. Furthermore, several in vitro and in vivo studies have revealed the effectiveness of resveratrol in various diseases such as diabetes mellitus, cardiovascular disease, metabolic syndrome, obesity, inflammatory, neurodegenerative, and age‐related diseases. This review presents an overview of currently available studies on preventive properties and essential molecular mechanisms involved in various diseases.

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Dietary Intake of Fiber and Decreased Risk of Cancers of the Colon and Rectum: Evidence From the Combined Analysis of 13 Case-Control Studies

Abstract: If causality is assumed, we estimate that risk of colorectal cancer in the U.S. population could be reduced about 31% (50,000 cases annually) by an average increase in fiber intake from food sources of about 13 g/d, corresponding to an average increase of about 70%.

Cited by 432 publications

References 32 publications

Dietary patterns and subsequent colorectal cancer risk by subsite: A prospective cohort study

Dietary patterns and subsequent colorectal cancer risk by subsite: A prospective cohort study

Butyrate- but not TGFβ1-induced apoptosis of colorectal adenoma cells is associated with increased expression of the differentiation markers E-cadherin and alkaline phosphatase

Resveratrol: A miraculous natural compound for diseases treatment

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