Dietary intake of fruits and beta-carotene is negatively associated with amyotrophic lateral sclerosis risk in Koreans: A case-control study

Abstract

The intake of fruits and beta-carotene decreases the risk of sporadic ALS in this present study. However, large prospective and interventional studies are needed to confirm the effect of fruits and beta-carotene intake on the risk of ALS.

Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk

“…The fish consuming study participants, particularly those in the top quartile for estimated annual methylmercury intake via fish, had significantly higher measured toenail mercury levels. Fish consumption increased risk of ALS in a multivariate model of dietary factors in Koreans . A prior case‐control study in Wisconsin related frequent consumption of fish caught in Lake Michigan with increased risk of ALS…”

“…Fish consumption increased risk of ALS in a multivariate model of dietary factors in Koreans. 30 A prior casecontrol study in Wisconsin related frequent consumption of fish caught in Lake Michigan with increased risk of ALS. 31 Some species of fish also contain omega-3 polyunsaturated fatty acids (PUFA), which were associated with numerous health benefits, including lower risk of ALS in dietary studies of prospective cohorts.…”

Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review

“…There is a beneficial association between ALS and the intake of carotenes (Okamoto et al, 2009;Nieves et al, 2016). Thus, their consumption could help the prevention and/or delay the onset of ALS (Fitzgerald et al, 2013) (Table 1) but in a case-controlled study with 77 Koreans diagnosed with ALS, it was determined that dietary intake of carotenes was negatively associated with ALS (Jin et al, 2014). A study conducted in 5 cohorts determined that a higher intake of these pigments was associated with a reduced risk of ALS and that high dietary intakes of ß-carotene and lutein were inversely associated with the risk of suffering from this disease.…”

Mercury and motor neuron disease: Hooked on a hypothesis

“…Case studies have largely relied on acute or subacute exposure to inorganic mercury. A relationship between fish consumption and methylmercury levels in humans appears well established …”

“…A relationship between fish consumption and methylmercury levels in humans appears well established. 2,4,29 The authors' findings raise many salient questions that require resolution before a pathogenic role of mercury in ALS can be accepted. As recognized by the authors, their study is small and will ideally be reproduced.…”