Dietary intake of potentially toxic elements and children's chemical exposure

Urbano, T. Guerrero; Zagnoli, Federico; Malavolti, Marcella; Halldórsson, Thorhallur I.; Filippini, Tommaso

doi:10.1016/j.coesh.2022.100393

Cited by 6 publications

(2 citation statements)

References 75 publications

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“…The potential pathways underlying BPA-induced adverse health outcomes include endocrine disruption (5), oxidative stress (6) and inflammation (7). Exposure to bisphenol A starts very early in life, causing adverse health outcomes not only in children but also later in life (8,9). The BPA exposure has been linked to disruptions in endocrine function and metabolism (10), which can contribute to the development of metabolic disorders (11).…”

Section: Introductionmentioning

confidence: 99%

Endocrine disrupting chemical Bisphenol A and its association with cancer mortality: a prospective cohort study of NHANES

Yuan,

Chen,

Ding

et al. 2024

Front. Public Health

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IntroductionThere is evidence suggesting that Bisphenol A (BPA) is associated with increased all-cause mortality in adults. However, the specific nature of the relationship between BPA exposure and cancer mortality remains relatively unexplored.MethodsThe National Health and Nutrition Examination Survey (NHANES) dataset was used to recruit participants. Urinary BPA was assessed using liquid chromatography-mass spectrum (LC–MS). Through the use of multivariable Cox proportional hazard regressions and constrained cubic splines, the relationships between urine BPA and death from all causes and cancer were investigated.ResultsThis study has a total of 8,035 participants, and 137 died from cancers after a 7.5-year follow-up. The median level of BPA was 2.0 g/mL. Urinary BPA levels were not independently associated with all-cause mortality. For cancer mortality, the second quartile’s multivariable-adjusted hazard ratio was 0.51 (95% confidence interval: 0.30 to 0.86; p = 0.011) compared to the lowest quartile. The restricted cubic splines showed that the association was nonlinear (p for nonlinearity = 0.028) and the inflection point was 1.99 ng/mL.ConclusionUrinary BPA exposure was U-shaped associated with the risk of cancer mortality, and a lower level of BPA less than 1.99 ng/mL was associated with a higher risk of cancer mortality.

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Section: Introductionmentioning

confidence: 99%

Endocrine disrupting chemical Bisphenol A and its association with cancer mortality: a prospective cohort study of NHANES

Yuan,

Chen,

Ding

et al. 2024

Front. Public Health

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“…In non-occupationally exposed individuals, food is the most important source of most elements [ 5 , 6 ]. Children are a particularly susceptible population, with their still developing systems, hand-to-mouth behavior and playing proximity to the floor, which can lead to inadvertent ingestion of contaminants present on surfaces and a higher uptake than adults (higher food intake per body weight) [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Trace Elements in Portuguese Children: Urinary Levels and Exposure Predictors

Correia-Sá,

Fernandes,

Maia

et al. 2023

Toxics

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Exposure to environmental chemicals during developmental stages can result in several adverse outcomes. In this study, the exposure of Portuguese children to Cu, Co, I, Mo, Mn, Ni, As, Sb, Cd, Pb, Sn and Tl was evaluated through the analysis of first morning urine through ICP-MS. Furthermore, we attempted to determine possible exposure predictors. The study sample consisted of 54% girls and 46% boys, with a median age of 10 years; 61% were overweight/obese and were put on a nutritionally oriented diet. For I, half of the population was probably in deficiency status. The median urinary concentrations (μg/L) were Cu 21.9, Mo 54.6, Co 0.76, Mn 2.1, Ni 4.74, As 37.9, Sb 0.09, Cd 0.29, Pb 0.94, Sn 0.45, Tl 0.39 and I 125.5. The region was a significant predictor for Cu, Co, Ni, As and Tl. Children living in an urban area had higher urinary levels, except for Co and Ni. Age was a significant predictor for Cu, I, Mo, Mn, Ni, Sb, Cd and Sn with urinary levels of these elements decreasing with age. No sex-related differences were observed. Diet and weight group were predictors for urinary Cu, Mn, Ni, Sb and As. Significant differences were observed between the diet/weight groups for Cu, Ni, Sb and As, with the healthy diet group presenting higher values.

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