Dietary Intake of Vitamin B6 and Risk of Breast Cancer in Taiwanese Women

Chou, Yu‐Ching; Chu, Chin-Chen; Wu, Mei-Hsuan; Hsu, Giu-Cheng; Yang, Tsan; Chou, Wan-Yun; Huang, Hsin-Ping; Lee, Meei-Shyuan; Yu, Cheng‐Ping; Yu, Jyh‐Cherng; Sun, Chien‐An

doi:10.2188/jea.je20100188

Cited by 22 publications

(17 citation statements)

References 40 publications

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“…Three studies that did not report the risk estimate were also excluded (Potera et al , 1977; Goodman et al , 2001; Schroecksnadel et al , 2003). Finally, 23 articles (Thorand et al , 1998; Wu et al , 1999a; Levi et al , 2001; Shrubsole et al , 2001; Feigelson et al , 2003; Zhang et al , 2003; Zhu et al , 2003; Lajous et al , 2006a; Lajous et al , 2006b; Cho et al , 2007; Kabat et al , 2008; Lin et al , 2008; Xu et al , 2008; Ma et al , 2009a; Ma et al , 2009b; Maruti et al , 2009a; Stevens et al , 2010; Chou et al , 2011; Shrubsole et al , 2011; Zhang et al , 2011; Lurie et al , 2012; Bassett et al , 2013; Yang et al , 2013) were included in this meta-analysis. The detailed steps of our literature search are shown in Supplementary Material.…”

Section: Resultsmentioning

confidence: 99%

Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose–response meta-analysis

Kang

Zhang

2013

Br J Cancer

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Background:Epidemiological studies evaluating the association of vitamin B6, vitamin B12 and methionine with breast cancer risk have produced inconsistent results.Methods:Pertinent studies were identified by a search in PubMed and Web of Knowledge. Random-effect model was used. Dose–response relationship was assessed by restricted cubic spline.Results:The combined relative risk (95% confidence interval) of breast cancer for the highest vs lowest category of serum pyridoxal 5′-phosphate (PLP, active form of vitamin B6) levels and dietary methionine intake was 0.80 (0.66–0.98, P=0.03) and 0.94 (0.89–0.99, P=0.03), respectively, and the associations of breast cancer with higher serum PLP levels and dietary methionine intake were significant among post-menopausal women, but not among pre-menopausal women. The inverse association between breast cancer risk and dietary vitamin B6 intake, serum vitamin B12 levels and dietary vitamin B12 intake was not significant overall. Linear dose–response relationship was found, and the risk of breast cancer decreased by 23% (P<0.00) for every 100 pmol ml−1 increment in PLP levels and 4% (P=0.05) for every 1 g per day increment in dietary methionine intake, respectively.Conclusion:Serum PLP levels and methionine intake might be inversely associated with breast cancer risk, especially among postmenopausal women, which need to be confirmed.

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Section: Resultsmentioning

confidence: 99%

Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose–response meta-analysis

Kang

Zhang

2013

Br J Cancer

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“…On the basis of PLP analyses only, vitamin B-6 was reported to be inversely associated with oxidative stress, inflammation, cardiovascular disease, diabetes, and cancer (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). Whether concentrations of the other vitamin B-6 vitamers are also relevant remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Inverse relations of vitamin B-6 with oxidative stress (3)(4)(5), inflammation (6)(7)(8)(9)(10), cardiovascular disease (11), diabetes (12), and cancer (13)(14)(15)(16)(17)(18)(19)(20)(21)(22) have been reported. A higher intake of vitamin B-6 is associated with a lower risk of colorectal cancer (13,19,22) and breast cancer (14,21), whereas higher concentrations of serum PLP are associated with a lower risk of lung cancer (18).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin B-6 vitamers in human plasma and cerebrospinal fluid

Albersen¹,

Bosma²,

Luykx³

et al. 2014

The American Journal of Clinical Nutrition

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“…100 enzymatic reactions by reducing oxidative stress, but also cell proliferation and angiogenesis, as it was shown ex vivo in the case of pyridoxal phosphate and pyridoxal in the concentration range: 0.05-0.25 mM, using human umbilical vein endothelial cells-HUVEC [5,25]. It participates in the catabolism of homocysteine to glutathione, thus affecting the antioxidant protection and detoxification of carcinogens [26,27]. Vitamin B2 plays a role in modifying the binding of carcinogens to DNA.…”

Section: Vitamin Chemoprevention?mentioning

confidence: 96%

B-Group Vitamins: Chemoprevention?

Gruber¹

2016

Adv Clin Exp Med

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The importance of vitamins in the prevention of cancer has attracted the attention of consumers, nutritionists and scientists for decades. The mechanisms of carcinogenesis, extended in the context of the function of vitamins, i.e. regulation of and participation in metabolic processes in the cell, suggest a substantial impact of these compounds on the initial stages of carcinogenesis. One-carbon metabolism involving folic acid, vitamins B2, B6 and B12, and folate metabolism doesn't only generate methyl groups, thus determining epigenetic processes, modifications of the genome and carcinogenesis. It also provides the compounds involved in the DNA synthesis and repair processes, especially the synthesis of purines and pyrimidines and the conversion of dUMP (2-deoxyuridine monophosphate) to dTMP (2-deoxythymidine monophosphate). In light of these pathways, folate, together with vitamins B2, B6 and B12, became a subject of interest as compounds whose deficit or surplus can potentially have an impact on the processes of carcinogenesis. Literature reports, however, do not fully confirm that the influence on the synthesis of nucleotides is connected with the inhibition of carcinogenesis. The impact of individual vitamins involved in one-carbon metabolism on carcinogenesis and their role in the prevention of these conditions depend on the type of cancer and the dose administered. Nevertheless, the research conducted makes it possible to conclude a considerable and probably long-underestimated role of these compounds in the prevention of serious, difficult to treat or incurable diseases (Adv Clin Exp Med 2016, 25, 3, 561-568).

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Dietary Intake of Vitamin B6 and Risk of Breast Cancer in Taiwanese Women

Cited by 22 publications

References 40 publications

Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose–response meta-analysis

Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose–response meta-analysis

Vitamin B-6 vitamers in human plasma and cerebrospinal fluid

B-Group Vitamins: Chemoprevention?

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