Dietary Intervention Prevents Dyslipidemia Associated With Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus Type 1–Infected Individuals

Lazzaretti, Rosmeri Kuhmmer; Kuhmmer, Regina; Sprinz, Eduardo; Polanczyk, Carísi Anne; Ribeiro, Jorge Pinto

doi:10.1016/j.jacc.2011.11.038

Cited by 66 publications

(69 citation statements)

References 29 publications

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“…The use of lipidlowering therapy was low and similar among centers, but no dietary intervention had been provided, even though there is evidence of benefit equivalent to lipidlowering agents [37]. Although the frequency of physical inactivity was much higher in Recife, the effectiveness of physical activity in improving the lipid profile in HIV-infected patients in routine conditions is still unclear [38].…”

Section: Discussionmentioning

confidence: 99%

Comparison between potential risk factors for cardiovascular disease in people living with HIV/AIDS in areas of Brazil

Ximenes

Lacerda

Miranda-Filho

et al. 2015

J Infect Dev Ctries

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Introduction: Coronary heart disease and its risk factors depend on genetic characteristics, behaviors, and habits, all of which vary in different regions. The use of antiretroviral therapy (ARV) has increased the survival of people living with HIV/AIDS (PLWHA), who begin to present mortality indicators similar to the general population. This study aimed to compare the prevalence of factors potentially associated with coronary heart disease in three cohorts of PLWHA from three different regions of Brazil. Methodology: The study population was composed of participants of the cohorts of Pernambuco, Goiás, and Rio Grande do Sul states. In these sites, adult patients attending reference centers for treatment of HIV/AIDS were consecutively enrolled. Results: Pernambuco and Goiás had a higher proportion of males and of individuals with high-risk high-density lipoprotein (HDL). Pernambuco also had a greater proportion of individuals with hypertension, elevated triglycerides, and CD4 counts below 200 cells/mm 3 . Lower education was more frequent in Rio Grande do Sul, and the use of cocaine was higher in this state. Conclusions: The results confirm the importance of risk factors for coronary heart disease in PLHIV and highlight differences in the three cohorts. Specific measures against smoking and sedentary lifestyle, avoidance of advanced stages of immunosuppression, and appropriate treatment of dyslipidemia and dysglicemia are urgently needed to cope with the disease in Brazil.

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Section: Discussionmentioning

confidence: 99%

Comparison between potential risk factors for cardiovascular disease in people living with HIV/AIDS in areas of Brazil

Ximenes

Lacerda

Miranda-Filho

et al. 2015

J Infect Dev Ctries

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“…According to Lazzaretti et al 22 , the risk of development of dyslipidemia in PLH with the use of ART in Brazil may be 70%. A Brazilian study evaluated PLH with and without the use of ART and observed significantly higher values of TC, LDL-c and TG in the population with the use of ART, illustrating the importance of identification of metabolic disorders before the initiation of ART, and adopting a multidisciplinary approach in this population with the aim of lifestyle modification 23 .…”

Section: Discussionmentioning

confidence: 99%

Metabolic disorders and cardiovascular risk in people living with HIV/AIDS without the use of antiretroviral therapy

Raposo

Armiliato

Guimarães

et al. 2017

Rev. Soc. Bras. Med. Trop.

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“…However, a very Citation: Spagnuolo MI, Liguoro I, Guarino A (2014) Metabolic Disorders in HIV-infected Children Metabolic Disorders in HIV-infected Children. J recent randomized study evaluated patients who had just begun HAART and prescribed a hypocaloric diet and were strictly followed, while controls had no diet and no nutritional follow-up [175]. This kind of approach resulted to prevent HAART-related dyslipidemia and lipodystrophy.…”

Section: Hiv and Dyslipidaemiamentioning

confidence: 99%

Metabolic Disorders in HIV-infected Children Metabolic Disorders in HIVinfected Children

Liguoro¹

2014

J Metabolic Synd

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The introduction of highly active antiretroviral therapy (HAART) for the treatment of acquired immunodeficiency syndrome (AIDS) has resulted in greater survival of patients infected with the human immunodeficiency virus (HIV). However, the use of these drugs has been associated with lipodystrophic syndrome (LS), which is characterized by metabolic alterations (dyslipidemia, insulin resistance, diabetes, and lactic acidosis) and abnormal corporal fat distribution. Clinically, LS may manifest as three different forms: lipohypertrophy (accumulation of fat in the central part of the body), lipoatrophy (loss of fat in the extremities, face and buttocks) and mixed (lipohypertrophy + lipoatrophy). Although its physiopathology has not been elucidated, some mechanisms have been described, including leptin and adiponectin deficiency, mitochondrial dysfunction and use of antiretroviral drugs. The type, dose and duration of the antiretroviral treatment, as well as age and puberty are the main risk factors. LS are also associated with increased incidence of cardiovascular illnesses, atherosclerosis and diabetes mellitus. Follow up must be periodic, consisting of measurement of body fat distribution, evaluation of the lipid profile and insulin resistance.

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Dietary Intervention Prevents Dyslipidemia Associated With Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus Type 1–Infected Individuals

Abstract: Among HIV-1-positive individuals naive of previous treatment, diet prevents dyslipidemia associated with HAART. (Effect of Nutritional Intervention on the Lipid Profile of HIV-Positive Patients Who Start HAART: a Randomized Trial; NCT00429845).

Cited by 66 publications

References 29 publications

Comparison between potential risk factors for cardiovascular disease in people living with HIV/AIDS in areas of Brazil

Comparison between potential risk factors for cardiovascular disease in people living with HIV/AIDS in areas of Brazil

Metabolic disorders and cardiovascular risk in people living with HIV/AIDS without the use of antiretroviral therapy

Metabolic Disorders in HIV-infected Children Metabolic Disorders in HIVinfected Children

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