Dietary Intervention to Reverse Carotid Atherosclerosis

Shai, Iris; Spence, J. David; Schwarzfuchs, Dan; Henkin, Yaakov; Párraga, Grace; Rudich, Assaf; Fenster, Aaron; Mallett, Christiane L.; Liel‐Cohen, Noah; Tirosh, Amir; Bolotin, Arkady; Thiery, Joachim; Fiedler, Georg Martin; Blüher, Matthias; Stümvoll, Michael; Stampfer, Meir J.

doi:10.1161/circulationaha.109.879254

Cited by 203 publications

(129 citation statements)

References 34 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…This follow-up study shows that the detrimental effect on carotid IMT is not permanent, similar to the positive effect of GHRT in AOGHD subjects, in whom it increases within 6 months from GH withdrawal (17). We also found that the number of individuals with atherosclerosis plaques did not further increase with longer follow-up, but in one individual the plaque disappeared, showing that despite some conflicting data (19,20), it is possible not only to reduce vascular wall volume but also to decrease plaques' volume as shown with some lipid-lowering agents (21,22). This occurred despite atherogenic conditions, such as abdominal obesity, increased SBP, LDL, and CRP (8,9,10).…”

Section: Discussionsupporting

confidence: 69%

Arrest of atherosclerosis progression after interruption of GH replacement in adults with congenital isolated GH deficiency

Araújo

Aguiar‐Oliveira

Oliveira

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: GH replacement therapy (GHRT) in adult-onset GH deficiency (AOGHD) reduces carotid intima-media thickness (IMT) and increases myocardial mass, with improvement of systolic and diastolic function. These observations have reinforced the use of GHRT on AOGHD. Conversely, we have previously reported that in adults with lifetime congenital and severe isolated GH deficiency (IGHD) due to a mutation in GHRH receptor gene (GHRHR), a 6-month treatment with depot GH increased carotid IMT, caused the development of atherosclerotic plaques, and an increase in left ventricular mass index (LVMI), posterior wall, and septal thickness and ejection fraction. Such effects persisted 12 months after treatment (12-month washout -12mo). Methods: We have studied the cardiovascular status (by echocardiography and carotid ultrasonography) of these subjects 60 months after completion of therapy (60-month washout -60mo). Results: Carotid IMT reduced significantly from 12 to 60mo, returning to baseline (pre-therapy) value. The number of individuals with plaques was similar at 12 and 60mo, remaining higher than pretherapy. LVMI, relative posterior wall thickness, and septum thickness did not change between 12 and 60mo, but absolute posterior wall increased from 12 to 60mo. Systolic function, evaluated by ejection fraction and shortening fraction, was reduced at 60mo in comparison with 12mo returning to baseline levels. The E/A wave ratio (expression of diastolic function) decreased at 60mo compared with both 12mo and baseline. Conclusions: In adults with lifetime congenital IGHD, the increase in carotid IMT elicited by GHRT was transitory and returned to baseline 5 years after therapy discontinuation. Despite this, the number of subjects with plaques remained stable at 60mo and higher than at baseline. 166 977-982 European Journal of Endocrinology

show abstract

Section: Discussionsupporting

confidence: 69%

Arrest of atherosclerosis progression after interruption of GH replacement in adults with congenital isolated GH deficiency

Araújo

Aguiar‐Oliveira

Oliveira

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…9 The low-carbohydrate diet also reportedly improves the estimated glomerular filtration rate (eGFR) in patients with chronic kidney disease stage 3 10 and contributes to regression of atherosclerosis. 11 As part of the re-evaluation of the low-carbohydrate diet, in 2012, Santos et al conducted a meta-analysis of randomized controlled trials of this diet. A total of 23 articles (17 studies) were selected from published clinical trials involving at least 100 subjects with an intervention period of at least 3 months.…”

Section: Nutrition Therapy In the Early Years Of Diabetology (Starvatmentioning

confidence: 99%

Paradigm Shifts in Nutrition Therapy for Type 2 Diabetes

Yamada

2017

Keio J. Med.

View full text Add to dashboard Cite

Currently, the low-energy diet is the only recognized nutrition therapy for type 2 diabetes in Japan. However, in recent decades, many foreign scientific organizations have accepted various nutritional approaches to manage diabetes, such as the low-carbohydrate diet, the Mediterranean diet, diet approaches to stop hypertension (DASH), and the vegetarian diet. Moreover, growing evidence has called into question classical nutritional approaches such as the low-fat diet for the prevention of cardiovascular disease and the low-protein diet for the prevention of diabetic kidney disease. Similarly, the recommended nutrition therapy for diabetes may change in near future. Such changes in nutrition therapy must be dynamic and based on not only scientific evidence but also each patient's narrative.

show abstract

“…Livsstilsintervensjoner har vist seg å kunne ha gunstig effekt på ateroskleroseutviklingen [31][32][33][34] . Det finnes også medikamenter som effektivt forbedrer disse tre risikofaktorene der det er nødvendig.…”

Section: Risikofaktorer For Hjerte-og Karsykdomunclassified