Dietary Iodine and Thyroid Cancer Risk in French Polynesia: A Case–Control Study

Cléro, Énora; Doyon, F; Chungue, Vaïana; Rachédi, Frédérique; Boissin, Jean-Louis; Sebbag, Joseph; Shan, Larrys; Bost-Bezeaud, Frédérique; Petitdidier, Patrice; Dewailly, Éric; Rubino, Carole; Vathaire, Florent de

doi:10.1089/thy.2011.0173

Cited by 70 publications

(81 citation statements)

References 24 publications

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“…Lastly, we estimated that traditional Polynesian dietary pattern was associated with a lower thyroid cancer incidence than western pattern (Clero et al, 2012a). French Polynesia is a mild iodine deficiency area in which a higher consumption of food from the sea and a higher dietary iodine intake are significantly associated with a decreased risk of thyroid cancer (Clero et al, 2012b). In this report we investigated the potential risk factors that have not been previously reported.…”

Section: Introductionmentioning

confidence: 93%

Differentiated Thyroid Carcinoma Risk Factors in French Polynesia

Xhaard¹,

Ren²,

Cléro³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 93%

Differentiated Thyroid Carcinoma Risk Factors in French Polynesia

Xhaard¹,

Ren²,

Cléro³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The increasing trend of obesity might be another factor that accounts for some of the observed increasing incidence of thyroid cancer, although the degree of its contribution is unclear. Both deficiency and overconsumption of iodine have been suggested to be risk factors for thyroid cancer, although the results from epidemiologic studies have been inconsistent (28)(29)(30). Based on the data from the National Health and Nutrition Examination Survey (NHANES), urinary iodine measurements have shown that the general U.S. population is iodine sufficient, although urinary iodine levels decreased by more than 50% between 1971 and 1974 and 1988 and 1994, and have remained stable since 2000 (31,32).…”

Section: Thyroid Cancer Epidemic 477mentioning

confidence: 99%

The Epidemic of Thyroid Cancer in the United States: The Role of Endocrinologists and Ultrasounds

Udelsman

Zhang

2014

Thyroid

206

128

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Background: The incidence of thyroid cancer has increased at an alarming rate in both men and women in the United States. The etiology of this epidemic is unclear. We tested the hypothesis that a significant component of this epidemic is due to increased detection of occult disease. We examined whether the density of endocrinologists and general surgeons as well as employment of cervical ultrasonography were factors associated with this epidemic. Methods: Thyroid cancer incidence rates by states were obtained from the United States Cancer Statistics 1999-2009 reported by the National Program of Cancer Registries. The densities of endocrinologists and general surgeons and the employment of cervical ultrasonography were calculated on a statewide basis and correlated with the incidence of thyroid cancer. Results: Age-standardized incidence rates of thyroid cancer have increased in every state in the United States. Significant regional variations were noted, with the highest incidence rates in the northeast and the lowest in the south. The incidence rates were significantly correlated with the density of endocrinologists (r = 0.58, p < 0.0001 for males; r = 0.44, p = 0.0031 for females) and the employment of cervical ultrasonography (r = 0.40, p = 0.0091 for males; r = 0.36, p = 0.0197 for females). Both the density of endocrinologists and general surgeons and employment of cervical ultrasonography could explain 57% of the variability in state-level incidence for males and 49% for females. Conclusions: These data offer evidence to suggest that the epidemic of thyroid cancer is due to increased detection of a reservoir of previously occult disease. The increased detection of thyroid cancer results in therapeutic interventions including surgery and radioactive thyroid treatment that may be of limited benefit.

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“…Our objective was to examine the association between fingernail selenium concentrations and thyroid cancer in French Polynesia, a country highly exposed to selenium mainly through fish consumption and characterized by mild iodine deficiency (Clero et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to other biomarker measures of selenium, such as blood or urine, nail concentrations represent longer-term exposure, typically the previous three to six months. This case-control study has already shown that a high number of pregnancies (Brindel et al, 2008), tallness and obesity (Brindel et al, 2009;Clero et al, 2010), familial history of thyroid cancer , low dietary intake of iodine (Clero et al, 2012), poor economic conditions , and nuclear radiation fallout , having a spring as the main source of drinking water (Xhaard et al, 2014) are thyroid cancer risk factors in French Polynesia.…”

Section: Introductionmentioning

confidence: 95%

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

Ren

Kitahara²,

González³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Numerous studies have suggested that selenium deficiency may be associated with an increased risk for several types of cancer, but few have focused on thyroid cancer. Materials and Methods: We examined the association between post-diagnostic fingernail selenium levels and differentiated thyroid cancer risk in a French Polynesian matched case-control study. Conditional logistic regression models were used to estimate odds ratios and 95% confidence intervals. Results: The median selenium concentration among controls was 0.76 μg/g. Significantly, we found no association between fingernail selenium levels and thyroid cancer risk after conditioning on year of birth and sex and additionally adjusting for date of birth (highest versus lowest quartile: odds-ratio=1.12, 95% confidence interval: 0.66-1.90; p-trend=0.30). After additional adjustment for other covariates, this association remained non-significant (p-trend=0.60). When restricting the analysis to thyroid cancer of 10 mm or more, selenium in nails was non-significantly positively linked to thyroid cancer risk (p-trend=0.09). Although no significant interaction was evidenced between iodine in nails and selenium in nails effect (p=0.70), a non-significant (p-trend =0.10) positive association between selenium and thyroid cancer risk was seen in patients with less than 3 ppm of iodine in nails. The highest fingernail selenium concentration in French Polynesia was in the Marquises Islands (M=0.87 μg/g) and in the Tuamotu-Gambier Archipelago (M=0.86 μg/g). Conclusions: Our results do not support, among individuals with sufficient levels of selenium, that greater long-term exposure to selenium may reduce thyroid cancer risk. Because these findings are based on post-diagnostic measures, studies with prediagnostic selenium are needed for corroboration.

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Dietary Iodine and Thyroid Cancer Risk in French Polynesia: A Case–Control Study

Cited by 70 publications

References 24 publications

Differentiated Thyroid Carcinoma Risk Factors in French Polynesia

Differentiated Thyroid Carcinoma Risk Factors in French Polynesia

The Epidemic of Thyroid Cancer in the United States: The Role of Endocrinologists and Ultrasounds

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

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