Dietary iron and the risk of lung cancer

Mohammadzadeh, Milad; Bahrami, Alireza; Ghafouri-Taleghani, Fatemeh; Khalesi, Saman; Abdi, Fatemeh; Hejazi, Ehsan

doi:10.1024/0300-9831/a000789

Cited by 5 publications

(1 citation statement)

References 62 publications

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“…A systematic review of the mechanistic studies of the link between heme iron intake and risk of colorectal cancer showed that these studies were based on levels of heme iron that were much higher than those in normal human diets, and concluded that there is insufficient evidence to confirm a mechanistic link (94). A meta-analysis of 59 studies (95) showed a borderline significant association between iron intake and colorectal cancer (RR 1.08, 95% CI 1.00-1.17) and no significant association with breast cancer or lung cancer, the latter which was supported by another recent meta-analysis (96). A study based on 1,126 cases and 1,173 matched controls did not show any significant association between serum ferritin concentrations and colorectal cancer (97).…”

Section: Iron and Risk Of Cancermentioning

confidence: 94%

Iron – a background article for the Nordic Nutrition Recommendations 2023

Domellöf,

Sjöberg

2024

Food & Nutrition Research

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Iron absorption from foods is generally lower than that of most other nutrients and is highly variable depending on individual iron status and iron bioavailability in the meal. Several large population groups in the Nordic and Baltic countries are at risk of iron deficiency, including infants, young children, menstruating females, pregnant women as well as vegetarians. Iron deficiency leads to anemia, fatigue, and limited capacity for physical activity. Of particular concern is that iron deficiency anemia in young children is associated with impaired neurodevelopment. A comprehensive literature search has been performed and summarized. New factorial calculations have been performed considering iron losses, iron absorption and iron requirements in various population groups. Recent data on iron intakes and the prevalence of iron deficiency in the Nordic countries are presented. Average requirements and tentative recommended intakes are presented for 12 different population groups. Pregnant women and those with high menstrual blood losses should consume iron-rich food and undergo screening for iron deficiency. Infants should consume iron-rich complementary foods and cow’s milk should be avoided as a drink before 12 months of age and limited to < 500 mL/day in toddlers. Vegetarians should consume a diet including wholegrains, legumes, seeds, and green vegetables together with iron absorption enhancers. There is no evidence that iron intake per se increases the risk of cancer or diabetes. Iron absorption from foods is generally lower than that of most other nutrients and can vary between <2 and 50% depending on individual iron status and iron bioavailability in the meal.

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Section: Iron and Risk Of Cancermentioning

confidence: 94%

Iron – a background article for the Nordic Nutrition Recommendations 2023

Domellöf,

Sjöberg

2024

Food & Nutrition Research

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Navigating heme pathways: the breach of heme oxygenase and hemin in breast cancer

Consoli,

Sorrenti,

Gulisano

et al. 2024

Mol Cell Biochem

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Breast cancer remains a significant global health challenge, with diverse subtypes and complex molecular mechanisms underlying its development and progression. This review comprehensively examines recent advances in breast cancer research, with a focus on classification, molecular pathways, and the role of heme oxygenases (HO), heme metabolism implications, and therapeutic innovations. The classification of breast cancer subtypes based on molecular profiling has significantly improved diagnosis and treatment strategies, allowing for tailored approaches to patient care. Molecular studies have elucidated key signaling pathways and biomarkers implicated in breast cancer pathogenesis, shedding light on potential targets for therapeutic intervention. Notably, emerging evidence suggests a critical role for heme oxygenases, particularly HO-1, in breast cancer progression and therapeutic resistance, highlighting the importance of understanding heme metabolism in cancer biology. Furthermore, this review highlights recent advances in breast cancer therapy, including targeted therapies, immunotherapy, and novel drug delivery systems. Understanding the complex interplay between breast cancer subtypes, molecular pathways, and innovative therapeutic approaches is essential for improving patient outcomes and developing more effective treatment strategies in the fight against breast cancer.

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Dietary and Serum Micronutrients Associations with Lung Cancer: Results from the NHANES 1988-2018 and Mendelian randomization study

Yi,

Xie,

et al. 2024

Preprint

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Background Numerous studies suggest a link between nutrients and lung cancer (LC) development, previous researches have produced conflicting results regarding the effects of diet-derived nutrient levels on LC risk. This study investigates the causal relationships between different types of lung cancer—including lung adenocarcinoma (LA), squamous cell lung cancer (SqCLC), and small cell lung cancer (SCLC)—and 12 dietary micronutrients, while also including calcium as an important mineral nutrient. We used National Health and Nutrition Examination Survey (NHANES) data to prove these associations, both in terms of diet and serum. Methods We selected instrumental variables (IVs) for the micronutrients based on recent genome-wide association studies (GWAS) and derived summary statistics for LC involving 33,057 cases and 545,462 controls. The causal inference analysis utilized the inverse-variance weighted (IVW) method, complemented by sensitivity analyses to validate the assumptions. The NHANES data, collected from 1988 to 2018, helped explore these associations, employing random forest imputation for missing data, propensity score analysis for confounding adjustment, and subgroup analyses to assess nutrient-cancer relationships. Machine learning techniques identified micronutrient most significantly associated with LC. Results Our findings suggest that higher dietary concentrations of vitamin B12 (OR: 0.30), zinc (OR: 0.06 for LA), vitamin D (OR: 0.60 for LA), and selenium (OR: 0.003 for SCLC) correlate with reduced LC risk. In the NHANES cohort of 14,421 participants, LC patients exhibited lower dietary intakes of the 12 micronutrients despite higher serum concentrations. Notably, machine learning results showed that elevated serum concentrations of calcium, zinc, and copper may also reduce the risk of LC. Conclusions These results indicate that zinc may protect against LC, particularly LA, while evidence for other nutrients is insufficient. The study also emphasizes the need for improved nutritional supplementation in LC patients.

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Dietary iron and the risk of lung cancer

Cited by 5 publications

References 62 publications

Iron – a background article for the Nordic Nutrition Recommendations 2023

Iron – a background article for the Nordic Nutrition Recommendations 2023

Navigating heme pathways: the breach of heme oxygenase and hemin in breast cancer

Dietary and Serum Micronutrients Associations with Lung Cancer: Results from the NHANES 1988-2018 and Mendelian randomization study

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