Dietary Iron Overload Persists in Rural Sub-Saharan Africa

Gordeuk, VR; Boyd, Rob; Brittenham, GaryM.

doi:10.1016/s0140-6736(86)91230-4

Cited by 103 publications

(38 citation statements)

References 12 publications

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“…This could be considered an important mechanism for iron over load in subjects of our study since there was concomitant increase in the magnitude of consumption of alcoholic drinks in the subgroups with history of iron intake. This possibility is supported by the reports of iron overload in the population of Zimbabweans and Southern African rural blacks having prolonged history of consumption of traditional beer in iron containers [31] [32].…”

Section: Discussionmentioning

confidence: 74%

High Incidence of Pulmonary Tuberculosis in ART Naive Remunerated Blood Donors with Human Immunodeficiency Virus Type-1 Infection: Possible Role of Iron Overload

Chattopadhya¹,

Baveja²

2018

JBM

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Iron overload is reported to be associated with immune alterations and increased susceptibility to infections. HIV infection is characterized by progressive immunodeficiency leading to invasion by opportunistic pathogens. It was of interest to find out if disease course in HIV type-1 infection could have any relation with alteration in body iron status among individuals with history of oral iron intake. A follow-up study of immunologic and virologic markers in relation to disease progression was undertaken on asymptomatic HIV-1 positive blood donors with history of oral iron intake (subgroup I) compared to those without such history (subgroup II). High serum iron was associated with elevated levels of Th 2 category of cytokines, heightened immune activation, faster decline in CD4 + T lymphocyte count and higher viral set point. Pulmonary tuberculosis (PT) was the most common AIDS related illness (ARI) (>70%) recorded among subgroup I compared to non-PT category of ARI. Median ARI free duration (months) was shorter among those who developed PT compared to those developing non-PT category of ARI i.e. 30 (95% CI as 26,32) versus 67(95% CI as 60,71) in subgroup I and 47 (95% CI as 42,49) versus 80 (95% CI as 72,87) in subgroup II (P < 0.001 for PT versus non-PT in both subgroups). Median survival duration (months) in the PT versus non-PT categories of ARI was 47 (95% CI as 42,48) versus 95 (95% CI as 90,100) in subgroup I and 71 (95% CI as 65,76) versus 107 (95% CI as 102,112) in subgroup II (P < 0.001 for PT versus non-PT in both subgroups). The present study indicates that body iron overload resulting from excess intake of iron may be associated with qualitative defects in cell mediated im-

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Section: Discussionmentioning

confidence: 74%

High Incidence of Pulmonary Tuberculosis in ART Naive Remunerated Blood Donors with Human Immunodeficiency Virus Type-1 Infection: Possible Role of Iron Overload

Chattopadhya¹,

Baveja²

2018

JBM

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“…3 Iron overload can occur in nonwhites and may be related to as-yet-undiscovered genetic mutations, environmental factors, or both. [4][5][6][7][8][9] The Hemochromatosis and Iron Overload Screening (HEIRS) study was designed to evaluate the prevalence, genetic and environmental determinants, and potential clinical, personal, and societal effects of iron overload and hemochromatosis in a multicenter, multiethnic sample of 101,168 primary care adults 25 years of age or older. This article reports findings from the first, or screening, stage of the study.…”

Section: Resultsmentioning

confidence: 99%

Hemochromatosis and Iron-Overload Screening in a Racially Diverse Population

et al. 2005

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“…Finally, although we have made great strides in understanding hemochromatosis in individuals of European descent, we remain largely ignorant of the causes and manifestations of iron overload in individuals of African descent, in spite of the apparent prevalence of the condition in that population. [201][202][203][204][205][206][207][208][209][210] Transfusional iron overload is relatively well understood. In my opinion, the goal in coming years should be to use biology, rather than chemistry, to treat it.…”

Section: Discussionmentioning

confidence: 99%