Dietary iron supplements and Moringa oleifera leaves influence the liver hepcidin messenger RNA expression and biochemical indices of iron status in rats

Saini, Ramesh Kumar; Manoj, P.; Shetty, Nandini P.; Srinivasan, Krishnapura; Giridhar, P.

doi:10.1016/j.nutres.2014.07.003

Cited by 74 publications

(53 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that the leaves have immense nutritional value such as minerals, vitamins and amino acids and as a result, the leaves have been used to combat malnutrition especially among infants and nursing mothers (Anjorin et al, 2010;Wakil and Kazeem, 2012). Recent studies have demonstrated the potential bioactives from leaves of Moringa oleifera (Saini et al, 2014c) and also showed the enrichment of carotenoids, tocopherols (Saini et al, 2014a) along iron bioavailability in animal models (Saini et al, 2014b). The flowers of Moringa oleifera have been found to be rich in potassium and calcium (Jideani and Diedericks, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of Moringa oleifera flower fortification on the nutritional quality and sensory properties of weaning food

Arise

Sanusi

et al. 2014

Croat. J. Food Sci. Technol.

View full text Add to dashboard Cite

SummaryMoringa oleifera is a nutrient rich plant that has the potential to combat malnutrition problems in Africa. This study aims to investigate the effect of fortification using Moringa oleifera flower powder on the sensory and proximate attributes of fermented yellow maize and millet blend (Ogi). The formulation was grouped into seven blends in ratio 100:0:0, 70:30:0, 70:25:5, 70:20:10, 70:15:15, 70:10:20, 70:5:25 for maize, millet and Moringa oleifera flower powder (MOFP) respectively. Moringa oleifera flower was air-dried for 5days, milled and sieved to obtained fine powder. The fine powder was mixed thoroughly with fermented maize and millet, wet milled and sieved. The proximate composition of fermented yellow maize and millet (Ogi) fortified with Moringa oleifera flower powder showed an increase in crude protein, crude fibre, ash and fat with increase in the levels of Moringa oleifera flower powder and decrease in carbohydrate and moisture content. Moisture, protein, fibre, fat, ash and carbohydrate contents varied in the range 7.92-9.74%, 10.46 _ 16.06%, 2.31-4.13%, 2.90-4.07%, 1.23-1.93% and 66.45-73.25% respectively. Sensory evaluation shows that blend 6 (20% MOFP) compared favourably with the control. Also, nutritional analysis shows that blend 6 is favourable as weaning food. Therefore, blend 6 formulation can be used as alternative to the weaning foods to improve the nutritional status of children and help to curb protein malnutrition.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of Moringa oleifera flower fortification on the nutritional quality and sensory properties of weaning food

Arise

Sanusi

et al. 2014

Croat. J. Food Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Folic acid was used as the source of folate in control diet. In our previous studies, dietary iron supplements from Moringa leaves were more beneficial compared to ferric citrate in overcoming the effects of iron deficiency (Saini et al 2014a). …”

Section: Discussionmentioning

confidence: 94%

“…The present study was designed to investigate the effect of dietary folate from Moringa leaves on body folate status and modulation of folate responsive genes in rat model by using well established folate depleted and repleted approach (Clifford et al 1989;Saini et al 2014a). In the present study, M. oleifera in particular was selected to establish the readily available and folate rich underutilized leafy vegetable as a source of dietary folate to prevent the folate deficiency.…”

Section: Discussionmentioning

confidence: 99%

Relative bioavailability of folate from the traditional food plant Moringa oleifera L. as evaluated in a rat model

et al. 2015

Self Cite

View full text Add to dashboard Cite

Moringa oleifera is an affordable and rich source of dietary folate. Quantification of folate by HPLC showed that 5-formyl-5,6,7,8-tetrahydrofolic acid (502.1 μg/100 g DW) and 5,6,7,8-tetrahydrofolic acid (223.9 μg/100 g DW) as the most dominant forms of folate in M. oleifera leaves. The bioavailability of folate and the effects of folate depletion and repletion on biochemical and molecular markers of folate status were investigated in Wistar rats. Folate deficiency was induced by keeping the animals on a folate deficient diet with 1 % succinyl sulfathiazole (w/w). After the depletion period, animals were repleted with different levels of folic acid and M. oleifera leaves as a source of folate. Feeding the animals on a folate deficient diet for 7 weeks caused a significant (3.4-fold) decrease in serum folate content, compared to non-depleted control animals. Relative bioavailability of folate from dehydrated leaves of M. oleifera was 81.9 %. During folate depletion and repletion, no significant changes in liver glycine N-methyl transferase and 5-methyltetrahydrofolatehomocysteine methyltransferase expression were recorded. In RDA calculations, only 50 % of natural folate is assumed to be bioavailable. Therefore, the bioavailability of folate from Moringa is much higher, suggesting that M. oleifera based food can be used as a significant source of folate.

show abstract

“…However, M. oleifera is also recorded as having a rich source of iron (Fe) (17.5 mg/100 g DW). In a bioavailability study conducted on a rat model, Fe from the Moringa leaf was found to be superior compared to ferric citrate, in overcoming iron deficiency [7].…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

“…The immature pods, flowers, and foliage of this tree are used for culinary purposes in different parts of the world [6]. The foliage of M. oleifera has been established as a rich source of phenolics and glucosinolates, minerals [7], tocopherols [8], carotenoids [9], polyunsaturated fatty acids [10], ascorbic acid [5], and folate [9]. Moringa seed oil also known as ''Ben oil'' is used for the production of biodiesel, because of the high content of monounsaturated fatty acids in form of oleic acid [11,12].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Constituents, Biological Activities, Therapeutic Potentials and Nutritional Values of <i>Moringa oleifera</i> (Zogale): A Review

Maizuwo¹

2017

JDDMC

View full text Add to dashboard Cite

Abstract:Moringa oleifera popularly known as Zogale in Northern Nigeria is one of the most widely distributed and cultivated plant species in the region. Moringa oleifera is a small or middle-sized tree, about 10m in height and is cultivated for different purposes such as vegetable, spice, medicine, for cooking and cosmetic oil. Different parts of this plant contain a profile of important minerals, and are a good source of protein, vitamins, β-carotene, amino acids and various phenolics. It was reported that Moringa trees are used to overcome malnutrition, especially in infants and nursing mothers, due to the presence of essential nutritional composition. Moringa leaves contain more vitamin A, calcium, iron, vitamin C, and potassium than carrots, milk, spinach, oranges and bananas respectively, and the protein quality of Moringa leaves is more than that of milk and eggs. An overview of phytochemical constituents present, biological activities, therapeutic potentials and their nutritional values are given in this paper.

show abstract

Dietary iron supplements and Moringa oleifera leaves influence the liver hepcidin messenger RNA expression and biochemical indices of iron status in rats

Cited by 74 publications

References 34 publications

Effect of Moringa oleifera flower fortification on the nutritional quality and sensory properties of weaning food

Effect of Moringa oleifera flower fortification on the nutritional quality and sensory properties of weaning food

Relative bioavailability of folate from the traditional food plant Moringa oleifera L. as evaluated in a rat model

Phytochemical Constituents, Biological Activities, Therapeutic Potentials and Nutritional Values of <i>Moringa oleifera</i> (Zogale): A Review

Contact Info

Product

Resources

About

Dietary iron supplements and Moringa oleifera leaves influence the liver hepcidin messenger RNA expression and biochemical indices of iron status in rats

Cited by 74 publications

References 34 publications

Effect of Moringa oleifera flower fortification on the nutritional quality and sensory properties of weaning food

Effect of Moringa oleifera flower fortification on the nutritional quality and sensory properties of weaning food

Relative bioavailability of folate from the traditional food plant Moringa oleifera L. as evaluated in a rat model

Phytochemical Constituents, Biological Activities, Therapeutic Potentials and Nutritional Values of &lt;i&gt;Moringa oleifera&lt;/i&gt; (Zogale): A Review

Contact Info

Product

Resources

About

Phytochemical Constituents, Biological Activities, Therapeutic Potentials and Nutritional Values of <i>Moringa oleifera</i> (Zogale): A Review