Dietary Long-Chain Polyunsaturated Fatty Acids from Different Sources Affect Fat and Fatty Acid Excretions in Rats

Amate, Laura; Gil, Ángel; Ramírez, Miguel Àngel Acedo

doi:10.1093/jn/131.12.3216

Cited by 26 publications

(16 citation statements)

References 39 publications

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“…Overall total lipid digestibility was lowest ( P < 0.02) in KO-fed rats which may be accounted for by fatty acids in KO being associated with PL. Amate and Ramirez [30] observed reduced absorption of n-3 LC-PUFAs in rats fed PL-rich pig brain. In contrast, infants and pre-term infants fed LC-PUFA PL as egg lecithin improved fat absorption [31,32].…”

Section: Discussionmentioning

confidence: 99%

Different sources of omega-3 polyunsaturated fatty acids affects apparent digestibility, tissue deposition, and tissue oxidative stability in growing female rats

et al. 2011

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BackgroundNumerous health benefits associated with increased omega-3 polyunsaturated fatty acid (n-3 PUFA) consumption has lead to an increasing variety of available n-3 PUFA sources. However, sources differ in the type, amount, and structural form of the n-3 PUFAs. Therefore, the objective of this study was to determine the effect of different sources of ω-3 PUFAs on digestibility, tissue deposition, eicosanoid metabolism, and oxidative stability.MethodsFemale Sprague-Dawley rats (age 28 d) were randomly assigned (n = 10/group) to be fed a high fat 12% (wt) diet consisting of either corn oil (CO) or n-3 PUFA rich flaxseed (FO), krill (KO), menhaden (MO), salmon (SO) or tuna (TO) oil for 8 weeks. Rats were individually housed in metabolic cages to determine fatty acid digestibility. Diet and tissue fatty acid composition was analyzed by gas chromatography and lipid classes using thin layer chromatography. Eicosanoid metabolism was determined by measuring urinary metabolites of 2-series prostaglandins (PGs) and thromoboxanes (TXBs) using enzyme immunoassays. Oxidative stability was assessed by measuring thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) using colorimetric assays. Gene expression of antioxidant defense enzymes was determined by real time quantitative polymerase chain reaction (RT-qPCR).ResultsRats fed KO had significantly lower DHA digestibility and brain DHA incorporation than SO and TO-fed rats. Of the n-3 PUFA sources, rats fed SO and TO had the highest n-3 PUFAs digestibility and in turn, tissue accretion. Higher tissue n-3 LC-PUFAs had no significant effect on 2-series PG and TXB metabolites. Despite higher tissue n-3 LC-PUFA deposition, there was no increase in oxidation susceptibility indicated by no significant increase in TBARS or decrease in TAC and gene expression of antioxidant defense enzymes, in SO or TO-fed rats.ConclusionsOn the basis that the optimal n-3 PUFA sources should provide high digestibility and efficient tissue incorporation with the least tissue lipid peroxidation, TO and SO appeared to be the most beneficial of the n-3 PUFAs sources evaluated in this study.

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Section: Discussionmentioning

confidence: 99%

Different sources of omega-3 polyunsaturated fatty acids affects apparent digestibility, tissue deposition, and tissue oxidative stability in growing female rats

et al. 2011

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“…FA absorption in the small intestine has been found equivalent for both the PL- and TG-derived compounds [34–38]. It has, however, been proposed that the different PL and TG ester forms could determine in which blood pool (free FAs, outer versus inner layer of chylomicrons, different lipoprotein particles) the FAs end up [39].…”

Section: Different Tissue Distribution Of Fas From Pl and Tg Estermentioning

confidence: 99%

Marine Omega-3 Phospholipids: Metabolism and Biological Activities

Burri

Hoem

Banni

et al. 2012

IJMS

222

186

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The biological activities of omega-3 fatty acids (n-3 FAs) have been under extensive study for several decades. However, not much attention has been paid to differences of dietary forms, such as triglycerides (TGs) versus ethyl esters or phospholipids (PLs). New innovative marine raw materials, like krill and fish by-products, present n-3 FAs mainly in the PL form. With their increasing availability, new evidence has emerged on n-3 PL biological activities and differences to n-3 TGs. In this review, we describe the recently discovered nutritional properties of n-3 PLs on different parameters of metabolic syndrome and highlight their different metabolic bioavailability in comparison to other dietary forms of n-3 FAs.

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“…It has been shown that dietary AA-PL is at least as efficacious as dietary AA-TAG to supply the developing organs with AA [155]. No direct information relates to the effects of DHA-TAG versus DHA-PL in this context [2, 5, 6, 38, 58, 106, 155]. …”

Section: Lipids In Human Milk and Infant Formulamentioning

confidence: 99%

Development of the Digestive System—Experimental Challenges and Approaches of Infant Lipid Digestion

Abrahamse

Minekus²,

Aken

et al. 2012

Food Dig.

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At least during the first 6 months after birth, the nutrition of infants should ideally consist of human milk which provides 40–60 % of energy from lipids. Beyond energy, human milk also delivers lipids with a specific functionality, such as essential fatty acids (FA), phospholipids, and cholesterol. Healthy development, especially of the nervous and digestive systems, depends fundamentally on these. Epidemiological data suggest that human milk provides unique health benefits during early infancy that extend to long-lasting benefits. Preclinical findings show that qualitative changes in dietary lipids, i.e., lipid structure and FA composition, during early life may contribute to the reported long-term effects. Little is known in this respect about the development of digestive function and the digestion and absorption of lipids by the newborn. This review gives a detailed overview of the distinct functionalities that dietary lipids from human milk and infant formula provide and the profound differences in the physiology and biochemistry of lipid digestion between infants and adults. Fundamental mechanisms of infant lipid digestion can, however, almost exclusively be elucidated in vitro. Experimental approaches and their challenges are reviewed in depth.

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Dietary Long-Chain Polyunsaturated Fatty Acids from Different Sources Affect Fat and Fatty Acid Excretions in Rats

Cited by 26 publications

References 39 publications

Different sources of omega-3 polyunsaturated fatty acids affects apparent digestibility, tissue deposition, and tissue oxidative stability in growing female rats

Different sources of omega-3 polyunsaturated fatty acids affects apparent digestibility, tissue deposition, and tissue oxidative stability in growing female rats

Marine Omega-3 Phospholipids: Metabolism and Biological Activities

Development of the Digestive System—Experimental Challenges and Approaches of Infant Lipid Digestion

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