Dietary Luffa cylindrica (L.) Roem promotes branched-chain amino acid catabolism in the circulation system via gut microbiota in diet-induced obese mice

Zhang, Lu; Yue, Yunshuang; Shi, M.; Tian, Mi; Ji, Junfu; Liao, Xiaojun; Hu, Xiaosong; Chen, Fang

doi:10.1016/j.foodchem.2020.126648

Cited by 41 publications

(34 citation statements)

References 43 publications

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“…63 Luffa cylindrica (L.) inhibits bacterial BCAAs biosynthesis, reduces BCAAs, and ameliorates BCAAs dysfunction, thus reducing obesity. 64…”

Section: Regulate the Levels Of Bile Acids And Other Metabolitesmentioning

confidence: 99%

<p>The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity</p>

Li¹,

Zhang²,

Li³

2020

DMSO

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Obesity is the lipid deposition caused by the imbalance between energy intake and consumption caused by a variety of factors. Obesity can lead to multiple systemic complications. At present, the treatment of obesity is mainly lifestyle intervention, drug weight loss, and weight loss surgery, but the curative effect is limited or the side effects are serious. Traditional Chinese medicine plays a unique role in the treatment of obesity. Existing studies have found that traditional Chinese medicine can treat obesity in a variety of ways, such as regulating intestinal microflora, enhancing hormone level, regulating fat metabolism, and so on. In this review, we will introduce and summarize the mechanism of traditional Chinese medicine in the treatment of obesity.

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“…63 Luffa cylindrica (L.) inhibits bacterial BCAAs biosynthesis, reduces BCAAs, and ameliorates BCAAs dysfunction, thus reducing obesity. 64…”

Section: Regulate the Levels Of Bile Acids And Other Metabolitesmentioning

confidence: 99%

<p>The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity</p>

Li¹,

Zhang²,

Li³

2020

DMSO

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“…Recent studies [ 47 , 48 ] have shown that BCAAs and AAAs are associated with disorders in energy balance, obesity, insulin resistance, and metabolic syndrome. Reductions in BCAAs and AAAs correlate with improved insulin sensitivity, as estimated by hyperinsulinemic–euglycemic clamp or homeostatic model assessment of insulin resistance (HOMA-IR) [ 49 ]. Mechanistically, BCAAs and AAAs suppress insulin-induced PI3K signaling and stimulate the activation of the mammalian target of rapamycin (mTOR), promoting the inappropriate phosphorylation of IRS-1 and further impairing insulin signaling transduction [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Sargassum fusiforme Alginate Relieves Hyperglycemia and Modulates Intestinal Microbiota and Metabolites in Type 2 Diabetic Mice

Liu

Yang

et al. 2021

Nutrients

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Sargassum fusiforme alginate (SF-Alg) possess many pharmacological activities, including hypoglycemic and hypolipidemic. However, the hypoglycemic mechanisms of SF-Alg remain unclear due to its low bioavailability. In this study, we evaluated the therapeutic effect of SF-Alg on high-fat diet (HFD)/streptozotocin (STZ)-induced type 2 diabetes (T2D) mice. SF-Alg intervention was found to significantly reduce fasting blood glucose (FBG), triglycerides (TG), and total cholesterol (TC), while increasing high-density lipoprotein cholesterol (HDL-c) and improving glucose tolerance. In addition, administrating SF-Alg to diabetic mice moderately attenuated pathological changes in adipose, hepatic, and heart tissues as well as skeletal muscle, and diminished oxidative stress. To probe the underlying mechanisms, we further analyzed the gut microbiota using 16S rRNA amplicon sequencing, as well as metabolites by non-targeted metabolomics. Here, SF-Alg significantly increased some benign bacteria (Lactobacillus, Bacteroides, Akkermansia Alloprevotella, Weissella and Enterorhabdus), and significantly decreased harmful bacteria (Turicibacter and Helicobacter). Meanwhile, SF-Alg dramatically decreased branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) in the colon of T2D mice, suggesting a positive benefit of SF-Alg as an adjvant agent for T2D.

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“…While it is difficult to adjust to a different dietary intake of individual AA in large human trials, animal studies allow for such a standardization and, therefore, for a more precise identification of microbiota-derived BCAA in the circulation. Several studies addressing the relationship between gut microbiota, circulating metabolites, and metabolic health were performed in animal models of obesity (mice fed a high-fat diet) [48,74] or diabetes (rats fed a high-fat diet and treated with streptozotocin) [75] (Table 2). In all models, serum BCAAs were significantly elevated and could be regarded as serum biomarkers of obesity-related insulin resistance.…”

Section: Animal Studiesmentioning

confidence: 99%

“…HFD induced significant changes in the gut microbiota composition characterized by the increased Firmicutes to Bacteroidetes ratio but, at the genus level, the outcomes were quite heterogeneous. Pathway analysis based on the metabolite abundances [48,75] or PICRUSt analysis based on the gut microbiota composition [74] identified an increased BCAA biosynthesis pathway in the HFD groups. The BCAA degradation pathway was decreased in HFD-fed mice only in the study of Zeng et al [48] but not in the others.…”

Section: Animal Studiesmentioning

confidence: 99%

“…BCAA composition as well as to the glucose metabolism-related parameters. To our knowledge, this effect was described after a treatment with citrus polymethoxyflavones (PMFE) [48], Luffa cylindrical (luffa) [74], berberine [77], glucomannans [75], and inulin [78]. The chemical nature of these compounds is quite heterogeneous.…”

Section: The Effect Of Microbiota Modulation With Phytochemicals or Symbiotics On The Bcaa Metabolismmentioning

confidence: 99%

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Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance

Gojda

Cahová

2021

Biomolecules

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The microbiota-harboring human gut is an exquisitely active ecosystem that has evolved in a constant symbiosis with the human host. It produces numerous compounds depending on its metabolic capacity and substrates availability. Diet is the major source of the substrates that are metabolized to end-products, further serving as signal molecules in the microbiota-host cross-talk. Among these signal molecules, branched-chain amino acids (BCAAs) has gained significant scientific attention. BCAAs are abundant in animal-based dietary sources; they are both produced and degraded by gut microbiota and the host circulating levels are associated with the risk of type 2 diabetes. This review aims to summarize the current knowledge on the complex relationship between gut microbiota and its functional capacity to handle BCAAs as well as the host BCAA metabolism in insulin resistance development. Targeting gut microbiota BCAA metabolism with a dietary modulation could represent a promising approach in the prevention and treatment of insulin resistance related states, such as obesity and diabetes.

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Dietary Luffa cylindrica (L.) Roem promotes branched-chain amino acid catabolism in the circulation system via gut microbiota in diet-induced obese mice

Cited by 41 publications

References 43 publications

<p>The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity</p>

<p>The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity</p>

Sargassum fusiforme Alginate Relieves Hyperglycemia and Modulates Intestinal Microbiota and Metabolites in Type 2 Diabetic Mice

Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance

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