Dietary Magnesium Intake Modifies the Association Between Vitamin D and Systolic Blood Pressure: Results From NHANES 2007–2014

Huang, Wei-Chao; Ma, Xiaoman; Chen, Yue; Zheng, Jiayi; Li, Haojia; Nizhamu, Ayinigaer; Hong, Qingting; Guo, Xu‐Guang

doi:10.3389/fnut.2022.829857

Cited by 6 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the positive effect of serum vitamin D on muscle strength ( 20 ), low magnesium intake might link with grip strength via affecting the synthesis and transport of 1,25(OH)2D. Similar interactions between low magnesium intake and serum 25(OH)D level were observed on insulin resistance, hypertension, diabetes, and cardiovascular mortality ( 17 – 19 , 40 ), but not on cognitive performance ( 41 ).…”

Section: Discussionmentioning

confidence: 82%

“…In addition, studies found that magnesium could affect the synthesis and metabolism of vitamin D ( 14 ), and meanwhile vitamin D could influence the absorption of magnesium ( 15 , 16 ). Interactive effect between magnesium intake and serum vitamin D status was observed on hypertension, diabetes and cardiovascular mortality ( 17 – 19 ). Considering the effect of vitamin D on muscle strength ( 20 ), whether interaction between magnesium intake and vitamin D also existed on muscle strength is unclear.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Associations between dietary magnesium intake and handgrip strength were modified by serum vitamin D level among the US elderly

Han

Gao²,

Gan³

2022

Front. Nutr.

View full text Add to dashboard Cite

ObjectiveThe present study aimed to evaluate the associations between dietary magnesium intake and handgrip strength, and whether these associations were affected by serum vitamin D status.MethodsA total of 2,127 participants aged 60 and above from the National Health and Nutrition Examination Survey (NHANES) of the 2011–2014 cycles were included in the analyses. Magnesium intake was obtained by 24-h dietary recalls and 30-day dietary supplement. Participants in the lowest sex-specific tertile of magnesium intake were defined as having low magnesium intake. Serum 25-hydroxyvitamin D [25(OH)D)] concentrations were examined by using ultra-high performance liquid chromatography tandem mass spectrometry and categorized into three levels: deficient, suboptimal, and sufficient. Handgrip strength was determined by using a dynamometer. Multivariable linear regression models were used to investigate the associations between dietary magnesium intake and handgrip strength.ResultsLow magnesium intake was not associated with handgrip strength, but interactions between low magnesium intake and serum 25(OH)D level existed on handgrip strength. The stratified analyses found that only in participants with deficient serum 25(OH)D, low magnesium intake was associated with reduced handgrip strength. The combined analyses shown that participants with both low magnesium intake and deficient serum 25(OH)D had highest decrease of handgrip strength.ConclusionFindings suggested that low magnesium intake was associated with reduced handgrip strength only in participants with deficient serum 25(OH)D. Increased magnesium intake was recommended for participants with deficient serum 25(OH)D in maintaining muscle strength.

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Associations between dietary magnesium intake and handgrip strength were modified by serum vitamin D level among the US elderly

Han

Gao²,

Gan³

2022

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…The observation that the association between magnesium status and grip strength persists in the subgroup of vitamin D sufficient individuals but not in those with deficiency, supports a potential interaction effect between the two nutrients [ 8 , 44 , 45 ]. Adequate levels of both, magnesium and vitamin D, may be needed for optimal muscle strength [ 46 – 48 ].…”

Section: Discussionmentioning

confidence: 89%

Association of magnesium and vitamin D status with grip strength and fatigue in older adults: a 4-week observational study of geriatric participants undergoing rehabilitation

et al. 2023

View full text Add to dashboard Cite

Background Low magnesium and vitamin D levels negatively affect individuals’ health. Aims We aimed to investigate the association of magnesium status with grip strength and fatigue scores, and evaluate whether this association differs by vitamin D status among older participants undergoing geriatric rehabilitation. Methods This is a 4-week observational study of participants aged ≥ 65 years undergoing rehabilitation. The outcomes were baseline grip strength and fatigue scores, and 4-week change from baseline in grip strength and fatigue scores. The exposures were baseline magnesium tertiles and achieved magnesium tertiles at week 4. Pre-defined subgroup analyses by vitamin D status (25[OH]D < 50 nmol/l = deficient) were performed. Results At baseline, participants (N = 253, mean age 75.7 years, 49.4% women) in the first magnesium tertile had lower mean grip strength compared to participants in the third tertile (25.99 [95% CI 24.28–27.70] vs. 30.1 [95% CI 28.26–31.69] kg). Similar results were observed among vitamin D sufficient participants (25.54 [95% CI 22.65–28.43] kg in the first magnesium tertile vs. 30.91 [27.97–33.86] kg in the third tertile). This association was not significant among vitamin D deficient participants. At week 4, no significant associations were observed between achieved magnesium tertiles and change in grip strength, overall and by vitamin D status. For fatigue, no significant associations were observed. Conclusions Among older participants undergoing rehabilitation, magnesium status may be relevant for grip strength, particularly among vitamin D sufficient individuals. Magnesium status was not associated with fatigue, regardless of vitamin D status. Study registration Clinicaltrials.gov, NCT03422263; registered February 5, 2018.

show abstract

“…9 Hypertension was de ned as being told by a doctor that you have hypertension. 10 Smoking status was categorized as smoking (having smoked 100 cigarettes in a lifetime) and nonsmoking (having never smoked 100 cigarettes in a lifetime). 11 Drinking status was categorized as drinking (at least once a month) and non-drinking (less than once a month).…”

Section: De Nition Of Covariatesmentioning

confidence: 99%

Association of Trouble Sleeping with Increased Risk of Gallstone Disease in U.S. Adults: A Cross-Sectional Study of NHANES 2017-2020

Liu,

Huang,

Huang

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Trouble sleeping is prevalent in modern society and is known to be associated with various health problems. However, studies on the relationship between trouble sleeping and gallstones are relatively few. This study aims to explore the potential association between trouble sleeping and gallstones among adult Americans. Methods Data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 were analyzed, including 7,438 adult participants. The relationship between trouble sleeping and gallstones was assessed using multivariable logistic regression models, with sensitivity analyses performed using multiple imputation, weighted analysis, and propensity score matching. Results Among the 7,438 participants, 780 (10.5%) reported having gallstones. The analysis showed a significantly increased risk of gallstones among participants with trouble sleeping (adjusted odds ratio [AOR] = 1.49, 95% confidence interval [CI] = 1.26–1.76, P < 0.001). Subgroup analyses indicated consistent associations across different subgroups based on sex, age, obesity, diabetes, and hypertension, with interaction observed in age subgroups. Conclusion The findings suggest that trouble sleeping may be an independent risk factor for gallstones. This highlights the potential importance of improving sleep quality in the prevention of gallstones.

show abstract

Dietary Magnesium Intake Modifies the Association Between Vitamin D and Systolic Blood Pressure: Results From NHANES 2007–2014

Cited by 6 publications

References 35 publications

Associations between dietary magnesium intake and handgrip strength were modified by serum vitamin D level among the US elderly

Associations between dietary magnesium intake and handgrip strength were modified by serum vitamin D level among the US elderly

Association of magnesium and vitamin D status with grip strength and fatigue in older adults: a 4-week observational study of geriatric participants undergoing rehabilitation

Association of Trouble Sleeping with Increased Risk of Gallstone Disease in U.S. Adults: A Cross-Sectional Study of NHANES 2017-2020

Contact Info

Product

Resources

About