Dietary Management of Skin Health: The Role of Genistein

Irrera, Natasha; Pizzino, Gabriele; D’Anna, Rosario; Vaccaro, Mario; Arcoraci, Vincenzo; Squadrito, Francesco; Altavilla, Domenica; Bitto, Alessandra

doi:10.3390/nu9060622

Cited by 61 publications

(45 citation statements)

References 51 publications

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“…[30] Furthermore, it has been reported to improve skin changes caused by aging. [31] Similar to quercetin and kaempferol, the amount of extracted genistein derivatives depended only on ethanol concentration as quadratic factor (Table 3). It is important to note that in the solutions prepared either with pure water or pure ethanol genistein peak was almost negligible ( Fig.…”

Section: Quercetin Kaempferol and Genistein Derivativesmentioning

confidence: 95%

Optimization of Ultrasound-Assisted Extraction of Phenolic Antioxidants from Lotus corniculatus

Fumić

Jug

Končić

2019

Croat. chem. acta (Online)

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Ultrasound-assisted extraction of phenolic antioxidants from Lotus corniculatus was optimized using response surface methodology. The extraction was performed according to the Box–Behnken design with ethanol concentration, temperature, and pH, as independent variables. The responses were extraction yield, DPPH radical scavenging activity (RSA) IC50 and content of different phenolic compounds (total phenols, flavonoids and phenolic acids, as well as quercetin, kaempferol and genistein derivatives). The models were used to calculate best conditions for maximal extraction of phenolic compounds and antiradical activity. Use of the optimized extraction parameters increased the content of quercetin and kaempferol derivatives more than tenfold (from 6.07 to 65.10 mg mL–1 and 6.69 to 92.75 mg mL–1, respectively). The results of this work stress the importance of careful selection of conditions for flavonoids extraction. Abundance of bioactive phenolics in L. corniculatus extracts obtained under optimized extraction conditions opens the possibility for wider utilization of this plant.

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Section: Quercetin Kaempferol and Genistein Derivativesmentioning

confidence: 95%

Optimization of Ultrasound-Assisted Extraction of Phenolic Antioxidants from Lotus corniculatus

Fumić

Jug

Končić

2019

Croat. chem. acta (Online)

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“…There is some limited evidence in support of this effect (Irrera et al . ). A health claim linking soy isoflavones with the maintenance of skin tonicity was rejected by EFSA as no evidence for a relationship between skin tonicity and skin function was supplied and, therefore, this was not classified a function of the body (EFSA Panel on Dietetic Products Nutrition and Allergies ).…”

Section: Popular Nutraceutical Ingredients and Skin Ageingmentioning

confidence: 97%

“…The authors hypothesised that soy isoflavones may have been responsible for the effects as these compounds are known to bind to estrogen receptors (hence the name phytoestrogens) and as post-menopausal status has been observed to correlate with reduced collagen production in the skin (Stevenson & Thornton, 2007), it is plausible that dietary isoflavones could correct this by mimicking estrogen. There is some limited evidence in support of this effect (Irrera et al 2017). A health claim linking soy isoflavones with the maintenance of skin tonicity was rejected by EFSA as no evidence for a relationship between skin tonicity and skin function was supplied and, therefore, this was not classified a function of the body (EFSA Panel on Dietetic Products Nutrition and Allergies 2011i).…”

Section: Combined Supplementsmentioning

confidence: 99%

Nutraceuticals and skin appearance: Is there any evidence to support this growing trend?

Spiro

Lockyer

2018

Nutrition Bulletin

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The rise of the nutraceutical market, specifically oral nutrition supplements claiming to improve skin appearance, is striking. This paper aims to examine the published scientific evidence for beneficial effects of nutraceuticals on skin appearance. An overview of skin physiology and intrinsic and extrinsic ageing is provided which underlies the potential physiological processes nutraceuticals purport to counter. Common ingredients used are explored. Some of these (vitamins A, C, B2, B3, B7, copper, iodine, zinc) have authorised skin‐related health claims, but many do not. Current evidence for those without existing authorised claims (e.g. green tea extract, pomegranate extract, carotenoids, evening primrose oil, borage oil, fish oil, collagen and co‐enzyme Q10) is reviewed, focussing primarily on evidence from randomised controlled trials where available, in relation to skin parameters including wrinkles and hydration. Issues of safety are also considered, and the postulated mechanisms for some emerging ingredients, such as cocoa flavanols and probiotics, are explored. Evidence from high quality human trials demonstrating clear benefit is required by regulatory authorities in order for foods and nutrition supplements to carry a health or beauty claim. To date, the evidence for many ingredients in relation to skin appearance is limited, not sufficiently robust and/or inconsistent. Although there are a small number of human studies suggesting a potential benefit and some plausible biological mechanisms, much of the evidence to date comes from animal and in vitro studies. There are simply not enough good quality randomised controlled trials in this area to draw firm conclusions about the benefit of nutraceuticals to skin appearance.

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“…GE acts as a selective estrogen receptor modulator. Several in vitro and in vivo studies demonstrated the beneficial effects of GE on skin, e.g., for the treatment of keloid scars, stimulation of collagen biosynthesis, acceleration of wound healing or protection of UVB-induced photodamage 147 .…”

Section: Genisteinmentioning

confidence: 99%

“…It has been reported to occur in many plants other than Citrus, such as in the families Fabaceae, Betulaceae, Lamiaceae and Papilionaceae. HE has been reported to possess significant antioxidant, anti-inflammatory, analgesic, immunomodulatory and wound healing effects 147 . Several reports also demonstrated a UVB-protective potential of HE in vitro 151,152 and in vivo 153,154 .…”

Section: Hesperidinmentioning

confidence: 99%

Ultraviolet A protective potential of plant extracts and phytochemicals

Škařupová

Vostalová

Svobodová

2020

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Chronic exposure to solar radiation is related to an increased incidence of various skin disorders, including premature skin aging and melanoma and non-melanoma skin cancers. Ultraviolet (UV) photons in particular are responsible for skin damage. Solar UV photons mainly belong to UVA wavebands, however UVA radiation has been mostly ignored for a long time. At the cellular level, UVA photons mainly provoke indirect oxidative damage to biomolecules via the massive generation of unstable and highly reactive compounds. Human skin has several effective mechanisms that forestall, repair and eliminate damage caused by solar radiation. Regardless, some damage persists and can accumulate with chronic exposure. Therefore, conscious protection against solar radiation (UVB+UVA) is necessary. Besides traditional types of photoprotection such as sunscreen use, new strategies are being searched for and developed. One very popular protective strategy is the application of phytochemicals as active ingredients of photoprotection preparations instead of synthetic chemicals. Phytochemicals usually possess additional biological activities besides absorbing the energy of photons, and those properties (e.g. antioxidant, anti-inflammatory) magnify the protective potential of phytochemicals and extracts. Therefore, compounds of natural origin are in the interest of researchers as well as developers. In this review, only studies on UVA protection with well-documented experimental conditions are summarized. This article includes 17 well standardized plant extracts (Camellia sinensis (L.) Kuntze, Silybum marianum L. Gaertn., Punica granatum L., Polypodium aureum L., Vaccinium myrtillus L., Lonicera caerulea L., Thymus vulgaris L., Opuntia ficus-indica (L.) Mill., Morinda citrifolia L., Aloe vera (L.) Burm.f., Oenothera paradoxa Hudziok, Galinsoga parviflora Cav., Galinsoga quadriradiata Ruiz et Pavón, Hippophae rhamnoides L., Cola acuminata Schott & Endl., Theobroma cacao L. and Amaranthus cruentus L.) and 26 phytochemicals.

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Dietary Management of Skin Health: The Role of Genistein

Cited by 61 publications

References 51 publications

Optimization of Ultrasound-Assisted Extraction of Phenolic Antioxidants from Lotus corniculatus

Optimization of Ultrasound-Assisted Extraction of Phenolic Antioxidants from Lotus corniculatus

Nutraceuticals and skin appearance: Is there any evidence to support this growing trend?

Ultraviolet A protective potential of plant extracts and phytochemicals

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