Dietary manganese affects the concentration, composition and sulfation pattern of heparan sulfate glycosaminoglycans in Sprague-Dawley rat aorta

Kalea, Anastasia Z.; Lamari, Fotini N.; Theocharis, Achilleas D.; Schuschke, Dale A.; Karamanos, Nikos K.

doi:10.1007/s10534-005-5893-x

Cited by 8 publications

(1 citation statement)

References 61 publications

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“…Manganese also sustains integrin activation in breast cancer cell migration even in the presence of zinc, a cation described to antagonize magnesium-dependent integrin activation [2]. Interestingly, manganese-deficient diet induces changes in rat aorta GAGs, which may lead to reduced vascular wall integrity and endothelial cell (EC) binding ability to circulating factors [57,58], two relevant events during hematogenous metastatic cell dissemination.…”

Section: Manganese Integrin Activation and Oxidative Stressmentioning

confidence: 99%

Metal ions and the extracellular matrix in tumor migration

et al. 2019

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In this review, we explore the roles of divalent metal ions in structure and function within the extracellular matrix (ECM), specifically, their interaction with glycosaminoglycans (GAGs) during tumor progression. Metals and GAGs have been individually associated with physiological and pathological processes, however, their combined activities in regulating cell behavior and ECM remodeling have not been fully explored to date. During tumor progression, divalent metals and GAGs participate in central processes, such as cell migration and angiogenesis, either by modulating cell surface molecules, as well as soluble signaling factors. In addition, studies on metals and polysaccharides interactions have been of great value, as they provide structural information that can be correlated with function. Finally, we believe that understanding how metals are regulated in physiological and pathological conditions is paramount for the development of new treatment strategies, as well as diagnostic and exploratory tools.

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Section: Manganese Integrin Activation and Oxidative Stressmentioning

confidence: 99%

Metal ions and the extracellular matrix in tumor migration

et al. 2019

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Relative and Combined Effects of Ethanol and Protein Deficiency on Bone Manganese and Copper

González-Pérez

González‐Reimers

DeLaVega-Prieto

et al. 2011

Biol Trace Elem Res

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Both manganese and copper may affect bone synthesis. Bone content of both metals can be altered in alcoholics, although controversy exists regarding this matter. To analyse the relative and combined effects of ethanol and a low protein diet on bone copper and manganese, and their relationships with bone structure and metabolism, including trabecular bone mass (TBM), osteoid area (OA), osteocalcin (OCN), insulin-like growth factor-1 (IGF-1), parathyroid hormone (PTH), urinary hydroxyproline (uHP) and vitamin D. Adult male Sprague-Dawley rats were divided into four groups. The control rats received a 18% protein-containing diet; a second group, an isocaloric, 2% protein-containing diet; a third one, an isocaloric, 36% ethanol-containing diet and a fourth, an isocaloric diet containing 2% protein and 36% ethanol. After sacrifice, TBM and OA were histomorphometrically assessed; bone and serum manganese and copper were determined by atomic absorption spectrophotometry, and serum OCN, IGF-1, PTH, uHP and vitamin D by radioimmunoassay. Ethanol-fed rats showed decreased TBM and bone manganese. Significant relationships existed between bone manganese and TBM, serum IGF-1 and OCN. Ethanol leads to a decrease in bone manganese, related to decreased bone mass and bone synthesis. No alterations were found in bone copper.

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