Dietary manipulation in musculoskeletal conditions

Rayman, Margaret P.; Pattison, Dorothy J

doi:10.1016/j.berh.2007.12.010

Cited by 22 publications

(13 citation statements)

References 102 publications

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“…There were no adverse reactions attributed to the drug other than digestive (flatulence and diarrhoea, fish-smelling eructations). The prespecified endpoints were reached and the study can be seen as a first demonstration of an effect of this product, confirming anecdotal reports of patient improvement and decreased use of NSAIDs, and the validity of some recommendations [22]. …”

Section: Discussionsupporting

confidence: 75%

“…Despite these mixed results and the calls for more clinical trials such as this one [21], there seems to be an agreement that fish-oil and essential minerals are appropriate to use in patients with OA, and in this respect the preparation tested here appears to correspond with recommendations [22]. …”

Section: Discussionmentioning

confidence: 99%

“…Some food supplements might also have effects on osteoarthritis symptoms [16-21], but few of these studies are methodologically valid. Authors have recommended testing fish-oils in patients with arthritis, and supplementation with minerals such as zinc or selenium, and vitamin E [22]. …”

Section: Introductionmentioning

confidence: 99%

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Phytalgic®, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial

et al. 2009

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IntroductionThe medicinal treatment of osteoarthritis (OA) is mostly symptomatic to relieve pain and incapacity with analgesics and non-steroidal anti-inflammatory drugs (NSAIDs), drugs with well-known risks. Complementary medicines might reduce the symptoms of OA and decrease the need for NSAIDs. This study tested the effects of a food supplement, Phytalgic®, on pain and function in patients with osteoarthritis and their use of analgesic and NSAIDs.MethodsA randomized double-blind parallel-groups clinical trial compared Phytalgic® (fish-oil, vitamin E, Urtica dioica) to a placebo for three months, in 81 patients with OA of the knee or hip using NSAIDs and/or analgesics regularly. The main outcome measures were use of NSAIDs (in Defined Daily Doses per day - DDD/day) or analgesics (in 500 mg paracetamol-equivalent tablets per week (PET/week) measured each month, and Western Ontario-McMaster University Osteo-Arthritis Index (WOMAC) function scales.ResultsAfter three months of treatment, the mean use of analgesics in the active arm (6.5 PET/week) vs. the placebo arm (16.5) was significantly different (P < 0.001) with a group mean difference of -10.0 (95% CI: -4.9 to -15.1). That of NSAIDs in the active arm (0.4 DDD/day) vs the placebo arm (1.0 DDD/day) was significantly different (P = 0.02) with a group mean difference of - 0.7 DDD/day (95% CI: -0.2 to -1.2). Mean WOMAC scores for pain, stiffness and function in the active arm (respectively 86.5, 41.4 and 301.6) vs the placebo arm (resp. 235.3, 96.3 and 746.5) were significantly different (P < 0.001) with group mean differences respectively of -148.8 (95% CI: -97.7 to -199.9), -54.9 (95% CI: -27.9 to -81.9) and -444.8 (95% CI: -269.1 to -620.4).ConclusionsThe food supplement tested appeared to decrease the need for analgesics and NSAIDs and improve the symptoms of osteoarthritis.Trial registrationClinicaltrials.gov NCT00666523.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

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Phytalgic®, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial

et al. 2009

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“…It thus is important to understand copper metabolic changes and copper-binding protein speciation alterations under specific disease conditions in order to make an attempt to manipulate copper transport and distribution. In this context, copper-related diseases such as neurodegenerative symptoms [5,6], cardiovascular structural and functional defects [7,8], bone metabolism disorders [9,10], musculature diseases [11,12] and deregulation of inflammatory responses [12,13] are all uncertain targets for copper manipulation therapy.…”

Section: Copper Nutrition and Metabolic Disordersmentioning

confidence: 99%

The significance of copper chelators in clinical and experimental application

Ding

Xie

Kang

2011

The Journal of Nutritional Biochemistry

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“…Evitar estos elementos puede reducir la permeabilidad gastrointestinal, lo que reduce los síntomas de la enfermedad 7 . Por último, las lectinas, que se encuentran en las legumbres y los cereales, pueden actuar como inmunógenos, alérgenos e irritantes intestinales, y puede interactuar directamente con las bacterias del tracto digestivo 8 .…”

Section: Lactancia Maternalunclassified

Recomendaciones dietéticas en la artritis reumatoide

Alhambra-Expósito

Arjonilla-Sampedro

Molina-Puerta

et al. 2013

Rev Esp Nutr Hum Diet

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La artritis reumatoide es una enfermedad sistémica crónica, con gran impacto en la vida social, emocional y física de los pacientes. Desde hace décadas, se han utilizado distintas dietas para tratar de mejorar los síntomas de las personas que la padecen. En este artículo se revisan los posibles beneficios de la terapia dietética en la artritis reumatoide. Los objetivos nutricionales en esta patología son frenar la pérdida de masa ósea, favorecer la recuperación de fracturas óseas y mejorar los trastornos inflamatorios asociadas al hueso y a las articulaciones. En general, se recomiendan dietas bajas en grasas saturadas, ricas en grasas polinsaturadas: omega 3 y omega 6, en hidratos de carbono complejos y fibra. Recomendaciones dietéticas en la artritis reumatoide

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Dietary manipulation in musculoskeletal conditions

Cited by 22 publications

References 102 publications

Phytalgic®, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial

Phytalgic®, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial

The significance of copper chelators in clinical and experimental application

Recomendaciones dietéticas en la artritis reumatoide

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