Dietary methionine restriction improves glucose metabolism in the skeletal muscle of obese mice

Luo, Tingyu; Yang, Yuhui; Xu, Yao; Gao, Qiuli; Wu, Guoqing; Jiang, Yuge; Sun, Jin; Shi, Yonghui; Li, Guowei

doi:10.1039/c8fo02571a

Cited by 31 publications

(36 citation statements)

References 61 publications

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“…It has been reported that even just 48 h MR improved glucose tolerance 42 . This may be attributable to enhanced glycogen synthesis, glycolysis and aerobic oxidation in the skeletal muscle of mice on MR and MR + HFD 43 . Indeed, we observed that MR restriction prevented or attenuated the HFDinduced reduction in SDH activity in the m. soleus and m. gastrocnemius of both young and old mice.…”

Section: Discussionmentioning

confidence: 99%

Methionine restriction plus overload improves skeletal muscle and metabolic health in old mice on a high fat diet

Swaminathan

Fokin

Venckūnas

et al. 2021

Sci Rep

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Methionine restriction (MR) has been shown to reduce the age-induced inflammation. We examined the effect of MR (0.17% methionine, 10% kCal fat) and MR + high fat diet (HFD) (0.17% methionine, 45% kCal fat) on body mass, food intake, glucose tolerance, resting energy expenditure, hind limb muscle mass, denervation-induced atrophy and overload-induced hypertrophy in young and old mice. In old mice, MR and MR + HFD induced a decrease in body mass. Muscle mass per body mass was lower in old compared to young mice. MR restored some of the HFD-induced reduction in muscle oxidative capacity. The denervation-induced atrophy of the m. gastrocnemius was larger in animals on MR than on a control diet, irrespective of age. Old mice on MR had larger hypertrophy of m. plantaris. Irrespective of age, MR and MR + HFD had better glucose tolerance compared to the other groups. Young and old mice on MR + HFD had a higher resting VO2 per body mass than HFD group. Mice on MR and MR + HFD had a resting respiratory quotient closer to 0.70, irrespective of age, indicating an increased utilization of lipids. In conclusion, MR in combination with resistance training may improve skeletal muscle and metabolic health in old age even in the face of obesity.

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Section: Discussionmentioning

confidence: 99%

Methionine restriction plus overload improves skeletal muscle and metabolic health in old mice on a high fat diet

Swaminathan

Fokin

Venckūnas

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In diet-induced obesity, mice display high levels of plasma adiponectin when restricting methionine, [90,91]. In male C57BL/6 J mice fed a 10 week long HFD to induce obesity, restricting methionine increases plasmatic but also skeletal muscle adiponectin, downregulates the mTOR pathway and upregulates MAPK and IRS-1 mRNA levels in gastrocnemius muscle, leading to an improvement in insulin sensitivity [92].…”

Section: Sulfur Based Amino Acids As a Potential Therapy For Obesitymentioning

confidence: 99%

Protein, amino acids and obesity treatment

Simonson

Boirie‌

Guillet

2020

Rev Endocr Metab Disord

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Dietary proteins have been used for years to treat obesity. Body weight loss is beneficial when it concerns fat mass, but loss of fat free massespecially muscle might be detrimental. This occurs because protein breakdown predominates over synthesis, thus administering anabolic dietary compounds like proteins might counter fat free mass loss while allowing for fat mass loss. Indeed, varying the quantity of proteins will decrease muscle anabolic response and increase hyperphagia in rodents fed a low protein diet; but it will favor lean mass maintenance and promote satiety, in certain age groups of humans fed a high protein diet. Beyond protein quantity, protein source is an important metabolic regulator: whey protein and plant based diets exercize favorable effects on the risk of developing obesity, body composition, metabolic parameters or fat free mass preservation of obese patients. Specific amino-acids like branched chain amino acids (BCAA), methionine, tryptophan and its metabolites, and glutamate can also positively influence parameters and complications of obesity especially in rodent models, with less studies translating this in humans. Tuning the quality and quantity of proteins or even specific amino-acids can thus be seen as a potential therapeutic intervention on the body composition, metabolic syndrome parameters and appetite regulation of obese patients. Since these effects vary across age groups and much of the data comes from murine models, long-term prospective studies modulating proteins and amino acids in the human diet are needed.

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“…Part of the mechanism behind the improved fasting insulin is dependent on SAAR-mediated increased sensitivity to insulin-dependent Akt phosphorylation in the liver [17]. In addition, obese mice subjected to dietary SAAR display increased plasma membrane localization of the GLUT4 glucose transporter and glycogen synthesis in gastrocnemius muscle, potentially contributing to improved insulin sensitivity in conjunction with SAAR [18].…”

Section: Sulfur Amino Acid Restriction As a Dietary Strategy To Prmentioning

confidence: 99%

Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights

2019

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Dietary sulfur amino acid restriction, also referred to as methionine restriction, increases food intake and energy expenditure and alters body composition in rodents, resulting in improved metabolic health and a longer lifespan. Among the known nutrient-responsive signaling pathways, the evolutionary conserved integrated stress response (ISR) is a lesser-understood candidate in mediating the hormetic effects of dietary sulfur amino acid restriction (SAAR). A key feature of the ISR is the concept that a family of protein kinases phosphorylates eukaryotic initiation factor 2 (eIF2), dampening general protein synthesis to conserve cellular resources. This slowed translation simultaneously allows for preferential translation of genes with special sequence features in the 5′ leader. Among this class of mRNAs is activating transcription factor 4 (ATF4), an orchestrator of transcriptional control during nutrient stress. Several ATF4 gene targets help execute key processes affected by SAAR such as lipid metabolism, the transsulfuration pathway, and antioxidant defenses. Exploration of the canonical ISR demonstrates that eIF2 phosphorylation is not necessary for ATF4-driven changes in the transcriptome during SAAR. Additional research is needed to clarify the regulation of ATF4 and its gene targets during SAAR.

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Dietary methionine restriction improves glucose metabolism in the skeletal muscle of obese mice

Abstract: Dietary methionine restriction (MR) has many positive effects on metabolic health.

Cited by 31 publications

References 61 publications

Methionine restriction plus overload improves skeletal muscle and metabolic health in old mice on a high fat diet

Methionine restriction plus overload improves skeletal muscle and metabolic health in old mice on a high fat diet

Protein, amino acids and obesity treatment

Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights

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