2024
DOI: 10.21203/rs.3.rs-4261007/v1
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Dietary methionine supplementation improves cognitive dysfunction associated with transsulfuration pathway upregulation in mouse models of subacute aging

Yuhui Yang,
Yuncong Xu,
Yonghui Shi
et al.

Abstract: Methionine (Met), an important substrate for protein synthesis and methyl donors, has also been shown to improve redox homeostasis in the body. However, its ability to ameliorate aging-induced cognitive dysfunction and the underlying mechanisms involved are still unknown. This study aimed to explore the effects of dietary Met supplementation on D-galactose-induced cognitive dysfunction and the associated mechanisms in mouse models of subacute aging. The mice were administrated 0.15 g/kg/day D-galactose subcuta… Show more

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