Dietary micronutrients/antioxidants and their relationship with bronchial asthma severity

Saux

The Journal of Immunology

et al. 2007

Asthma is driven by allergic airway inflammation and involves increased levels of oxidative stress. This has led to speculation that antioxidants like selenium (Se) may play important roles in preventing or treating asthma. We fed diets containing low (0.08 parts per million), medium (0.25 parts per million), or high (2.7 parts per million) Se to female C57BL/6 mice and used an established OVA challenge protocol to determine the relationship between Se intake and the development of allergic airway inflammation. Results demonstrated that mice fed medium levels of Se had robust responses to OVA challenge in the lung as measured by lung cytokine levels, airway cellular infiltrate, eosinophilia, serum anti-OVA IgE, airway hyperreactivity, goblet cell hyperplasia, and phosphorylated STAT-6 levels in the lung. In contrast, responses to OVA challenge were less robust in mice fed low or high levels of Se. In particular, mice fed low Se chow showed significantly lower responses compared with mice fed medium Se chow for nearly all readouts. We also found that within the medium Se group the expression of lung glutathione peroxidase-1 and liver selenoprotein P were increased in OVA-challenged mice compared with PBS controls. These data suggest that Se intake and allergic airway inflammation are not related in a simple dose-response manner, which may explain the inconsistent results obtained from previous descriptive studies in humans. Also, our results suggest that certain selenoproteins may be induced in response to Ag challenges within the lung.

Section: Discussionsupporting

confidence: 34%

“…Some descriptive studies in humans have suggested that lower levels of serum Se are associated with the increased prevalence and severity of asthma (15)(16)(17). Other studies have failed to verify such correlations (18,19). To gain insight into the relationship between dietary Se and the pathogenesis of asthma, we conducted a series of in vivo experiments.…”

mentioning

confidence: 99%

A Role for Dietary Selenium and Selenoproteins in Allergic Airway Inflammation

Saux

The Journal of Immunology

et al. 2007

“…Because asthma involves increased levels of oxidative stress, Se intake has been hypothesized to play a role in the development and/or severity of this complex disease. However, descriptive studies in humans have produced conflicting results with some finding an association between low Se status and asthma (2)(3)(4)(5), and others failing to confirm this association (6)(7)(8). Dietary Se has even been found to be positively associated with severity of bronchial responsiveness (9).…”

mentioning

confidence: 96%

Selenium and asthma: a complex relationship

2008

Allergy

Descriptive studies in humans investigating the relationship between selenium (Se) status and asthma have presented inconsistent results. The concept of low Se status as a potential risk factor for increased prevalence or severity of asthma is based on the role that Se, through its incorporation into selenoproteins, plays as a potent antioxidant capable of augmenting the oxidative stress that accompanies asthma. However, Se intake also exerts a significant influence over immune responses. Thus, the dual effects of Se status on controlling oxidative stress in the lungs and regulating T helper 2 responses that drive allergic asthma, as well as which selenoproteins are key to regulating these processes, must be considered when attempting to decipher the relationship between this essential nutrient and complex allergic diseases such as asthma.

“…16 19 allerjik, 17 non-allerjik astımlı hastanın plazma çinko dü-zeyleri sağlıklı çocuklarla aynı bulunmuşken43 yapılan bir diğer çalışmada da 118 astımlı ve 121 sağlıklı çocuğun çinko düzeyleri arasında farklılık saptanmamış olup hastalık şidde-ti ile ilişkili olmadığı gösterilmiştir. 14 Çinko düzeylerinin diğer alerjik hastalıkların teşhis ve tedavisinde rolü net değildir.…”

unclassified

Role of Zinc Deficiency in Allergic Diseases

Özdemir¹,

Tabanlı²

2016

Sakarya Med J

ÖzÇinko organizma için esansiyel olup vücutta en bol bulunan ikinci eser elementtir. Hücrelerin yapısal ve fonksiyonel bütünlüğü için kritik bir role sahiptir. Ciddi çinko eksikliğinde büyüme geriliği, hipogonadizm, cilt hastalıkları, tat ve koku bozuklukları, bağışıklık sisteminde bozukluk, nöronal ve sensoral bozukluklar gibi birçok patolojiler ortaya çıkabilir. Günümüzde çinko eksikliği tüm dünyada yaygın bir sorun olarak bilinmektedir. Bu derlemede çinko eksikliğinin insan sağlığı üzerindeki ciddi etkileri ve alerjik hastalıklar ile ilişkisi anlatılmaktadır. Abstract Zinc is an essential for the organism, is the second most abundant trace element in the body. It is critical for the structural and functional integrity of cells. Many pathologies may occur in