Dietary Modifications for Refractory Chronic Rhinosinusitis? Manipulating diet for the Modulation of Inflammation

Nayan, Smriti; Maby, Alexandra; Endam, Léandra Mfuna; Desrosiers, Martin

doi:10.2500/ajra.2015.29.4220

Cited by 13 publications

(15 citation statements)

References 71 publications

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“…A low salicylic acid diet has been explored as a therapeutic intervention in these patients. In some studies, the elimination in the diet for 6-12 weeks of food containing salicylates like fruits, vegetables, herbs, spices, almonds, and several oils improved the nasal symptoms and nasal endoscopy findings of individuals with AERD [69,[147][148][149]. Table 6 shows a list of food containing high, intermediate, and low levels of salicylic acid; in general, food with high and even intermediate salicylates level should be avoided in highly sensitive patients [150,151].…”

Section: Non-pharmacological Treatmentmentioning

confidence: 99%

Aspirin exacerbated respiratory disease: Current topics and trends

Rodríguez-Jiménez

Moreno-Paz

Terán

et al. 2018

Respiratory Medicine

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Aspirin-exacerbated respiratory disease is a chronic and treatment-resistant disease, characterized by the presence of eosinophilic rhinosinusitis, nasal polyposis, bronchial asthma, and nonsteroidal anti-inflammatory drugs hypersensitivity. Alterations in arachidonic acid metabolism may induce an imbalance between pro-inflammatory and anti-inflammatory substances, expressed as an overproduction of cysteinyl leukotrienes and an underproduction of prostaglandin E2. Although eosinophils play a key role, recent studies have shown the importance of other cells and molecules in the development of the disease like mast cells, basophils, lymphocytes, platelets, neutrophils, macrophages, epithelial respiratory cells, IL-33 and thymic stromal lymphopoietin, making each of them promissory diagnostic and treatment targets. In this review, we summarize the most important clinical aspects of the disease, including the current topics about diagnosis and treatment, like provocation challenges and aspirin desensitization. We also discuss recent findings in the pathogenesis of the disease, as well as future trends in diagnosis and treatment, including monoclonal antibodies and a low salicylate diet as a treatment option.

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Section: Non-pharmacological Treatmentmentioning

confidence: 99%

Aspirin exacerbated respiratory disease: Current topics and trends

Rodríguez-Jiménez

Moreno-Paz

Terán

et al. 2018

Respiratory Medicine

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“…Targeting the reduction of systemic inflammation through diet-induced gut microbiome manipulation could be of great use. This could be concretely achieved by promoting better eating habits such as changing to a Mediterranean diet; taking probiotics, as proposed by Nayan et al 51 ; or reducing red meat consumption. 70 Manipulation of the microbiome at the nasal and sinus mucosal level may also be a possible strategy, either via selective targeting of pathogenic bacteria or via supplementation with ''healthy'' Gram-positive probiotic bacteria.…”

Section: Microbiome Dysbiosismentioning

confidence: 99%

Do Aging Factors Influence the Clinical Presentation and Management of Chronic Rhinosinusitis?

Renteria

Endam

Desrosiers

2017

Otolaryngol.--head neck surg.

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Objective/Hypothesis Chronic rhinosinusitis (CRS) is a complex inflammatory disease of the upper respiratory airways resulting from the dysregulation of immunity and epithelial defenses. More recently, the contribution of an altered nasal microbiome to the development of CRS has also been proposed. However, the impact of aging on the development of CRS has been long overlooked. Here we propose, in a hypothesis piece, that aging can influence the physiopathology of CRS and its subsequent management in an elderly population. Data Sources We summarize the recent literature findings supporting that elderly patients with CRS could be a distinct population from those with adult CRS and might require different or adjunct therapeutic approaches. Methods Review of recent literature of the effect of aging and its possible effects in CRS using 3 different databases. Conclusions Age-dependent decrease in the levels of the S100 family proteins involved in epithelial proliferation, repair, and defenses combined with chronic inflammation might lead to an increased risk of abnormal microbial colonization and loss of microbiota diversity. Ultimately, these changes could have the potential to alter the physiopathology of CRS in the elderly. Implications Unlike in adults, in whom CRS T2-skewed responses with eosinophilia are thought to play a critical role, in aging populations, a microbiome and epithelial barrier dysfunctions may instead be the pivotal agents of disease development and persistence. This supports that therapies for elderly patients may require a different management or additional targeted therapies to control the disease. Prospective studies, however, are necessary to validate this concept.

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“…The interaction between diet and CRS is complex and poorly understood. A number of special diets including a low salicylate diet have a theoretical basis for being able to modulate the chronic inflammation seen in CRS, but the evidence for the clinical application of dietary adjustment in management is lacking and is not recommended in national guidelines 23 . In a small randomized control crossover trial of 10 N-ERD patients, Sommer et al investigated the use of the low salicylate diet as a management option in N-ERD and observed an improvement in both subjective and objective outcome measures in patients following the diet for a 6-week period 6 .…”

Section: Discussionmentioning

confidence: 99%

Exploring the association between ingestion of foods with higher potential salicylate content and symptom exacerbation in chronic rhinosinusitis. Data from the National Chronic Rhinosinusitis Epidemiology Study

Philpott¹,

Smith²,

Davies‐Husband³

et al. 2019

Rhin

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This study has been reported in accordance with the STROBE statement guidelines for the reporting of observational studies. Word count = 3009controls, but especially in the CRSwNPs and AFRS phenotypes. Further studies are needed to detail if this relationship represents a causal relationship to dietary salicylate. The data present the possibility that a wider group of CRS patients may elicit salicylate sensitivity than those with known N-ERD.

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Dietary Modifications for Refractory Chronic Rhinosinusitis? Manipulating diet for the Modulation of Inflammation

Cited by 13 publications

References 71 publications

Aspirin exacerbated respiratory disease: Current topics and trends

Aspirin exacerbated respiratory disease: Current topics and trends

Do Aging Factors Influence the Clinical Presentation and Management of Chronic Rhinosinusitis?

Exploring the association between ingestion of foods with higher potential salicylate content and symptom exacerbation in chronic rhinosinusitis. Data from the National Chronic Rhinosinusitis Epidemiology Study

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