Dietary Modulation of the Multistage, Multimechanisms of Human Carcinogenesis: Effects on Initiated Stem Cells and Cell–Cell Communication

Trosko, James E.

doi:10.1207/s15327914nc5401_12

Cited by 32 publications

(26 citation statements)

References 101 publications

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“…Plant polyphenols as catechins of tea 23,24 are involved in cellcell interactions responsible for their anticarcinogenic activity by upregulating the receptor and signaling cascades of communication between cells. Well known cardiovascular protective effect of plant polyphenols can also be explained by influence of these compounds on interaction between endothelial cells.…”

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confidence: 99%

Plant polyphenols in cell-cell interaction and communication

Tarahovsky

2008

Plant Signaling & Behavior

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Plant polyphenols including flavonoids and tannins are important constituent of our everyday diet and medical herbals. It is broadly accepted that polyphenols may protect us from toxins, carcinogens and pollutants though the mechanisms of the polyphenols action is still not clear. Here we discuss the ability of polyphenols and especially gallate rich compounds like tannins and catechin gallates to interact with proteins and lipids, establish binding between adjacent bilayer surfaces and initiate membrane aggregation. This phenomena discovered in model experiments could also influence lateral segregation and compartmentalization of cell surface compounds and assist the cell-cell interaction and signal transduction. The involvement of plant polyphenols in communication between cells could be an important factor responsible for anticarcinogenic, vascular and cardioprotective activity of these compounds and speculated to be implicated in the evolution of human brain and intelligence.Plant polyphenols including flavonoids and tannins are present on our daily diet. The opinion on their influence on the human health is contradictory and ranges widely from positive to skeptic and even to alarming. [1][2][3] Obviously the processes of their functioning in our body should be studied in more details.The polyphenols are know not only as patent antioxidants but also as cell metabolism regulators. 4 The biological functioning of these compounds begins from their interaction with the cell surface and penetration through the plasma membrane into the cytoplasm. They can influence various physical properties of membrane lipids including diffusion, melting temperature, detergent solubility, osmotic stability, permeability to water soluble compounds 5-7 and general parameters of lipid packing and intrinsic bilayer curvature related to membrane interaction and fusion. Their penetration through the lipid bilayer inversive correlates with the number of hydroxyl groups and accordingly with the hydrophobicity of molecules.The background of polyphenols functioning is attributed to the ability of these compounds to interact with proteins, lipids and polynucleotides through electrostatic, hydrophobic, and even covalent binding. [6][7][8][9] The polyphenolic compounds are generally not very active chemically and only electrostatic and hydrophobic forces are responsible for their interaction within cells. However, after oxidation of catechol and gallate 10 moieties to quinones (Fig. 1) in presence of peroxidases, polyphenol oxidases, alkaline pH, or transition metals they could be involved in reactions with free nucleophilic functional groups such as sulfhydryl, amine, amide, indole and imidazole substituents; 11 and result in covalent binding with different residues including lysine, methionine, cysteine and tryptophane. 8,12 We expect that terminal amino groups of phosphatidylethanolamines or sulfolipids of biological membranes can also participate in covalent binding with quinones. The consequence of chemical derivatization of proteins ma...

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Plant polyphenols in cell-cell interaction and communication

Tarahovsky

2008

Plant Signaling & Behavior

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“…Normal maintenance of any organism means that cells replicate by division to replace old cells and repair any damaged tissue areas. Cell division starts with DNA replication, which takes place in a normal human's lifetime approximately 10 16 times. Even though the DNA replication system is extremely accurate, opportunities for errors occur and these may cause mutations.…”

Section: The Beginnings Of Cancermentioning

confidence: 99%

“…In this case, the organism's ability to counter-attack this effect is very important to stop the production of cancerous cells. Nutrients such as zinc, selenium, vitamins A and C, n-3 PUFAs and probiotics modulate the immune response or act as antioxidants, helping the immune system to work specifically against the cancerous cell and not against normal adjacent cells 15,16 . Apoptosis or programmed cell death is the most important mechanism for the maintenance of normal tissues and organs.…”

Section: The Role Of Nutrition In Cancer Developmentmentioning

confidence: 99%

Nutrition and immunity in cancer

Valdés‐Ramos

Benítez‐Arciniega

2007

Br J Nutr

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The purpose of this article is to give a general overview of the effects of nutrition on the development of cancer as well as part of a therapeutic approach. There is much evidence that diet and lifestyle can alter the risk of cancer development as is the case for many other chronic diseases. This may be through a direct action on the immune system, either by enhancing or suppressing it, as well as on the development of the tumour itself, by modulating gene expression or by antioxidant activity. Protective effects can be achieved by adequate intakes of vitamins A and C, β-carotene, selenium and n-3 fatty acids among others, while negative effects are found mainly with high intakes of n-6 and saturated fatty acids. Weight gain, obesity and lack of regular physical activity have also been associated with an increased risk of cancer. The protective effects are best observed when adequate diet and lifestyle are present together. With respect to the therapeutic role of nutrition in cancer, it has been observed that the use of pre- or post-operative enteral or parenteral nutrition may improve patients' survival rates and quality of life; however, more research is needed in this particular area. Breast, colon, rectum, prostate, stomach and lung are the types of cancer most commonly associated with diet or dietary components.

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“…Today, an individual or a society finds it difficult to develop its own (personal or cultural) view of the world because those rather indestructible "walls" of our ancestors shaped our early socialization. Therefore, the rather obvious state of our current global survival, being jeopardized by an exploding human population, global pollution of air, water, limiting nutritional foods, miserable human existence for billions of human beings (Potter 1988), unrealistic or bankrupt ideologies, philosophical/political theories, religious theologies (Sagan 1995;Trosko 2002;Trosko 1984), and being exacerbated by natural disasters (recent tsunami in Japan), needs a new vision as to how, on one hand, to prevent the serious threat to decent human existence survival, and on the other hand, to plan for a sustainable ecology to meet an ever changing impact on our limiting physical and chemical resouces.…”

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confidence: 99%

Global Bioethical Prevention of the Collision of Biological and Cultural Evolution on Miserable Human Survival

Troskoa¹

2015

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With the cultural myth that science can only determine the way the world "is" (facts), while humanities, social sciences, lawyers, philosophers, and theologians must determine the way the world "ought to be" (values), those in position of global-, national-, and local-political power make major decisions of the use (or non-use) of scientific knowledge and technology. As a result, the human being has created a non-scientifically based cultural environment that is affecting his ability to survive. In effect, cultural evolution is occurring more rapidly than biological evolution that can adapt to the changes brought about in the physical and psycho-social environments. In a pluralistic cultural world, where each society has generated a different view of human nature and different ethical values, the use, misuse, or non-use of scientific and technological advances are derived from these unscientific views of human nature. Since all life depends on limiting interacting environmental and ecological factors, it is imperative that scientific information be used to govern how to minimize irreversible effects on life-sustaining ecological factors, but also scientific information bearing on understanding human nature ought to be integrated into a "global bioethics". While ethical values cannot be directly derived from scientific factors, it is also true that human values or our "ought" cannot be maintained in ignorance or defiance of the facts or the "is".

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Dietary Modulation of the Multistage, Multimechanisms of Human Carcinogenesis: Effects on Initiated Stem Cells and Cell–Cell Communication

Cited by 32 publications

References 101 publications

Plant polyphenols in cell-cell interaction and communication

Plant polyphenols in cell-cell interaction and communication

Nutrition and immunity in cancer

Global Bioethical Prevention of the Collision of Biological and Cultural Evolution on Miserable Human Survival

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