Dietary Monounsaturated Fatty Acids but not Saturated Fatty Acids Preserve the Insulin Signaling Pathway via IRS‐1/PI3K in Rat Skeletal Muscle

Moon, Jae Hoon; Lee, Ji Young; Kang, Saet Byol; Park, Jong Suk; Lee, Byung Wan; Kang, Eun Seok; Ahn, Chul Woo; Lee, Hyun Chul; Soo, Bong

doi:10.1007/s11745-010-3475-3

Cited by 39 publications

(26 citation statements)

References 22 publications

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“…Similarly, in a meta-analysis of randomized controlled trials looking at the effects of MUFA on glycemic control in individuals with abnormal glucose metabolism, diets high in MUFA were shown to significantly reduce HbA1c [54]. Human trials and animal studies suggest that MUFA may also be involved in the insulin-signaling pathway by playing a role in membrane translocation of glucose transporters in skeletal muscle, as well as by buffering β-cell hyperactivity and insulin resistance [54]–[56]. Although our results do not show significant improvements in insulin resistance by HOMA or fasting insulin levels, there were a limited number of trials and a significant amount of heterogeneity present in the primary analyses.…”

Section: Discussionmentioning

confidence: 99%

Effect of Tree Nuts on Glycemic Control in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Dietary Trials

et al. 2014

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BackgroundTree nut consumption has been associated with reduced diabetes risk, however, results from randomized trials on glycemic control have been inconsistent.ObjectiveTo provide better evidence for diabetes guidelines development, we conducted a systematic review and meta-analysis of randomized controlled trials to assess the effects of tree nuts on markers of glycemic control in individuals with diabetes.Data SourcesMEDLINE, EMBASE, CINAHL, and Cochrane databases through 6 April 2014.Study SelectionRandomized controlled trials ≥3 weeks conducted in individuals with diabetes that compare the effect of diets emphasizing tree nuts to isocaloric diets without tree nuts on HbA1c, fasting glucose, fasting insulin, and HOMA-IR.Data Extraction and SynthesisTwo independent reviewer’s extracted relevant data and assessed study quality and risk of bias. Data were pooled by the generic inverse variance method and expressed as mean differences (MD) with 95% CI’s. Heterogeneity was assessed (Cochran Q-statistic) and quantified (I2).ResultsTwelve trials (n = 450) were included. Diets emphasizing tree nuts at a median dose of 56 g/d significantly lowered HbA1c (MD = −0.07% [95% CI:−0.10, −0.03%]; P = 0.0003) and fasting glucose (MD = −0.15 mmol/L [95% CI: −0.27, −0.02 mmol/L]; P = 0.03) compared with control diets. No significant treatment effects were observed for fasting insulin and HOMA-IR, however the direction of effect favoured tree nuts.LimitationsMajority of trials were of short duration and poor quality.ConclusionsPooled analyses show that tree nuts improve glycemic control in individuals with type 2 diabetes, supporting their inclusion in a healthy diet. Owing to the uncertainties in our analyses there is a need for longer, higher quality trials with a focus on using nuts to displace high-glycemic index carbohydrates.Trial RegistrationClinicalTrials.gov NCT01630980

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Section: Discussionmentioning

confidence: 99%

Effect of Tree Nuts on Glycemic Control in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Dietary Trials

et al. 2014

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“…Regarding the potential mechanisms explaining the effects of MUFA on glycaemic control, membrane translocation of glucose transporter type 4 was decreased in the skeletal muscle of rats being on a diet rich in saturated fat [37]. These changes in the insulin signalling pathway could not have been observed in rats fed a high-MUFA diet.…”

Section: Discussionmentioning

confidence: 99%

“…These changes in the insulin signalling pathway could not have been observed in rats fed a high-MUFA diet. The authors concluded that the beneficial effect of dietary MUFA on insulin sensitivity is associated with a conserved IRS-1/PI3 kinase insulin signalling pathway, which was altered by saturated fatty acids [37]. In addition, high levels of adiponectin have been shown to be associated with a reduced risk of T2D [38].…”

Section: Discussionmentioning

confidence: 99%

Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis

Schwingshackl¹,

Strasser²,

Hoffmann³

2011

Ann Nutr Metab

132

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Background/Aims: In 2008, the American Diabetes Association recommended low-carbohydrate or low-fat diets for weight management in patients with established type 2 diabetes (T2D), while the amount of monounsaturated fatty acids (MUFA) was not specified. This systematic review focused on the effects of diets high in MUFA versus diets low in MUFA on important risk factors of T2D (i.e. plasma glucose, insulin, homeostasis model assessment of insulin resistance and glycosylated haemoglobin, HbA1c). Methods: Nine randomized controlled intervention trials with a total of 1,547 participants and a running time of at least 6 months, comparing diets high versus low in MUFA among adults with abnormal glucose metabolism (T2D, impaired glucose tolerance and insulin resistant), being overweight or obese, have been included in the meta-analysis. We performed a random effects meta-analysis to determine the weighted mean differences with 95% confidence intervals using the software package Review Manager 5.0.25 of the Cochrane Collaboration. Results: Significant differences in HbA1c were found (weighted mean difference –0.21%, 95% CI –0.40 to –0.02; p = 0.03), favouring the high MUFA groups. In contrast, fasting plasma glucose, fasting plasma insulin as well as the homeostasis model assessment of insulin resistance were not affected by the amounts of MUFA in the dietary protocols. Conclusions: In summary, this systematic review found that high MUFA diets appear to be effective in reducing HbA1c, and therefore, should be recommended in the dietary regimes of T2D.

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“…In animal models MUFA improve insulin sensitivity in muscle as compared with saturated fatty acids by a mechanism related to the membrane translocation of GLUT4. 38 In humans, some studies have found a reduction in insulin resistance with diets rich in MUFA 39,40 whereas others have not found this relation 41 or even detected a positive relation between the intake and levels of MUFA and insulin resistance. 42,43 In subjects with high fasting triglyceride concentrations, a high MUFA meal causes a lower postprandial rise of insulin that a meal high in saturated fatty acids.…”

Section: Discussionmentioning

confidence: 99%

Olive oil has a beneficial effect on impaired glucose regulation and other cardiometabolic risk factors. Di@bet.es study

et al. 2013

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BACKGROUND: Despite the marked increase in cardiovascular risk factors in Spain in recent years, the prevalence and incidence of cardiovascular diseases have not risen as expected. Our objective is to examine the association between consumption of olive oil and the presence of cardiometabolic risk factors in the context of a large study representative of the Spanish population. SUBJECTS AND METHODS: A population-based, cross-sectional, cluster sampling study was conducted. The target population was the whole Spanish population. A total of 4572 individuals aged X18 years in 100 clusters (health centers) were randomly selected with a probability proportional to population size. The main outcome measures were clinical and demographic structured survey, lifestyle survey, physical examination (weight, height, body mass index, waist, hip and blood pressure) and oral glucose tolerance test (OGTT) (75 g). RESULTS: Around 90% of the Spanish population use olive oil, at least for dressing, and slightly fewer for cooking or frying. The preference for olive oil is related to age, educational level, alcohol intake, body mass index and serum glucose, insulin and lipids. People who consume olive oil (vs sunflower oil) had a lower risk of obesity (odds ratio ( CONCLUSIONS:The results show that consumption of olive oil has a beneficial effect on different cardiovascular risk factors, particularly in the presence of obesity, impaired glucose tolerance or a sedentary lifestyle.

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Dietary Monounsaturated Fatty Acids but not Saturated Fatty Acids Preserve the Insulin Signaling Pathway via IRS‐1/PI3K in Rat Skeletal Muscle

Cited by 39 publications

References 22 publications

Effect of Tree Nuts on Glycemic Control in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Dietary Trials

Effect of Tree Nuts on Glycemic Control in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Dietary Trials

Effects of Monounsaturated Fatty Acids on Glycaemic Control in Patients with Abnormal Glucose Metabolism: A Systematic Review and Meta-Analysis

Olive oil has a beneficial effect on impaired glucose regulation and other cardiometabolic risk factors. Di@bet.es study

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