Dietary Morus alba L. leaf supplementation improves hepatic lipid accumulation of laying hens via downregulating CircACACA

Chen, Fang; Huang, Jing; Zhao, Na; Jin, Feng; Fan, Qiwen; Du, Encun; Wei, Jintao

doi:10.1016/j.psj.2023.103042

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…Transformation is the result of multiple factors, such as breed, sex, age, and internal regulatory factors, among which circRNA has also been identified as an important regulator (Ferraro et al, 2014). CircRNAs are a type of covalently closed circular RNA molecule with a stable structure that participates in various cell activities, including fatty acid oxidation, gluconeogenesis, and mitochondrial biogenesis (Chen et al, 2023). In porcine skeletal muscle, circMYLK4 could promote the development of slow muscle fibers, (Cao et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

circUSP13 facilitates the fast‐to‐slow myofiber shift via the MAPK/ERK signaling pathway in goat skeletal muscles

Zhang,

Kang,

Deng

et al. 2024

Journal Cellular Physiology

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Understanding how skeletal muscle fiber proportions are regulated is essential for understanding muscle function and improving the quality of mutton. While circular RNA (circRNA) has a critical function in myofiber type transformation, the specific mechanisms are not yet fully understood. Prior evidence indicates that circular ubiquitin‐specific peptidase 13 (circUSP13) can promote myoblast differentiation by acting as a ceRNA, but its potential role in myofiber switching is still unknown. Herein, we found that circUSP13 enhanced slow myosin heavy chain (MyHC‐slow) and suppressed MyHC‐fast expression in goat primary myoblasts (GPMs). Meanwhile, circUSP13 evidently enhanced the remodeling of the mitochondrial network while inhibiting the autophagy of GPMs. We obtained fast‐dominated myofibers, via treatment with rotenone, and further demonstrated the positive role of circUSP13 in the fast‐to‐slow transition. Mechanistically, activation of the mitogen‐activated protein kinase/extracellular signal‐regulated kinase (MAPK/ERK) pathway significantly impaired the slow‐to‐fast shift in fully differentiated myotubes, which was restored by circUSP13 or IGF1 overexpression. In conclusion, circUSP13 promoted the fast‐to‐slow myofiber type transition through MAPK/ERK signaling in goat skeletal muscle. These findings provide novel insights into the role of circUSP13 in myofiber type transition and contribute to a better understanding of the genetic mechanisms underlying meat quality.

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Section: Discussionmentioning

confidence: 99%

circUSP13 facilitates the fast‐to‐slow myofiber shift via the MAPK/ERK signaling pathway in goat skeletal muscles

Zhang,

Kang,

Deng

et al. 2024

Journal Cellular Physiology

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Emerging roles of circular RNAs on the regulation of production traits in chicken

You,

Long,

Shen

et al. 2025

Poultry Science

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The Effect of Mulberry Silage Supplementation on the Carcass Fatness and Long-Chain Fatty Acid Composition of Growing Lambs Compared with Traditional Corn Silage

Cao,

Zhao,

Zheng

et al. 2024

Foods

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Lamb meat has become very popular with consumers in recent years due to its nutritional benefits. As a lean red meat, lamb is an important natural source of polyunsaturated and saturated fatty acids, which can be modified by adjustments in livestock feed. This study used proteomic and metabolic analyses to compare a basal ration supplemented with either mulberry silage or corn silage. Supplementation with mulberry silage led to a reduction in subcutaneous carcass fatness compared with corn silage. Additionally, changes in the proteome associated with fatty acid metabolism and oxidation resulted in decreased levels of saturated and trans fatty acids, while significantly increasing the levels of α-linolenic acid (ALA) and oleic acid and reducing linoleic acid content.

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Dietary Morus alba L. leaf supplementation improves hepatic lipid accumulation of laying hens via downregulating CircACACA

Cited by 3 publications

References 39 publications

circUSP13 facilitates the fast‐to‐slow myofiber shift via the MAPK/ERK signaling pathway in goat skeletal muscles

circUSP13 facilitates the fast‐to‐slow myofiber shift via the MAPK/ERK signaling pathway in goat skeletal muscles

Emerging roles of circular RNAs on the regulation of production traits in chicken

The Effect of Mulberry Silage Supplementation on the Carcass Fatness and Long-Chain Fatty Acid Composition of Growing Lambs Compared with Traditional Corn Silage

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