Dietary Mutagen Exposure and Risk of Pancreatic Cancer

Li, Donghui; Day, R. Sue; Bondy, Melissa L.; Sinha, Rashmi; Nguyen, Nga; Evans, Douglas B.; Abbruzzese, James L.; Hassan, Manal M.

doi:10.1158/1055-9965.epi-06-0993

Cited by 52 publications

(62 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The second study, a large hospital-based case control (n = 626 cases), similar to our study, showed an overall significant 52% increased pancreatic cancer risk for the highest compared with the lowest DiMeiQx intake quintile (P trend = 0.02); however, when 60th percentile mutagen intake based on the distribution of the controls was used as the cut-point for comparison, all meat mutagens except PhIP show significant elevated risks ranging from 1.4 to 1.5 (22). These studies show patterns of risk between the meat-related mutagens and pancreatic cancer, similar to the associations that we observe in the NIH-AARP Diet and Health Study for DiMeiQx in both sexes and PhIP among men, such that positive risk is only observed in the highest quintile of intake (22,45). Most populations consume cooking-related meat mutagens at very low concentrations with skewed distributions such that few have high intake at which genotoxic and carcinogenic effects may occur and subsequent risk is observed.…”

Section: Discussionsupporting

confidence: 78%

“…**Meat doneness level. reported earlier (22,45), support the notion that meatrelated mutagens are consumed in small quantities, and associations with cancer are observed only at high intake. The strong, 2-fold, positive association we observed with overall meat-derived mutagenic activity suggests that the integration of all classes of meat-related mutagens is a more comprehensive exposure measurement of meat-derived mutagens compared with individual HCA and B(a)P and/or that mutagens not yet identified beyond the HCAs and B(a)P may contribute to pancreatic carcinogenesis.…”

Section: Discussionsupporting

confidence: 73%

“…The Multiethnic Cohort Study, which has a substantial number of pancreatic cancer cases (n = 482), reported significant 45% and 68% increased risks in the highest compared with the lowest intake of red and processed meat, respectively (26). Meat-cooking methods and pancreatic cancer risk has been evaluated in one cohort study that reported no associations (30) and eight case-control studies (2,3,8,9,12,13,19,22), five of which showed greater pancreatic cancer risk for fried or grilled/barbecued meats, with odds ratios ranging from 2.2 to 16.7 (3,8,9,12,22). Two recent pancreatic cancer case-control studies have employed a meat-cooking module and mutagen database similar to that used in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, some of the cohort studies have <100 cases (23,25) and may have limited power to observe associations. In addition, dietary assessment tools used to ascertain meat consumption have often lacked detailed questions about meat, meatcooking methods, and doneness level, with only two case-control studies examining meat mutagens and pancreatic cancer risk (12,22). These methodologic hindrances could lead to misclassification of the mutagenic potential of meat exposure and, hence, inaccurate risk estimates.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Meat and Meat-Mutagen Intake and Pancreatic Cancer Risk in the NIH-AARP Cohort

Stolzenberg‐Solomon¹,

Cross²,

Silverman³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

Self Cite

108

128

View full text Add to dashboard Cite

Meat intake, particularly red meat, has been positively associated with pancreatic cancer in some epidemiologic studies. Detailed meat-cooking methods and related mutagens formed in meat cooked at high temperatures have not been evaluated prospectively as risk factors for this malignancy. We investigated the association between meat, meat-cooking methods, meat-mutagen intake, and exocrine pancreatic cancer in the NIH-American Association of Retired Persons (NIH-AARP) Diet and Health Study cohort of 537,302 individuals, aged 50 to 71 years, with complete baseline dietary data (1995)(1996) ascertained from a food frequency questionnaire. A meat-cooking module was completed by 332,913 individuals 6 months after baseline. During 5 years of follow-up, 836 incident pancreatic cancer cases (555 men, 281 women) were identified. Four hundred and fifty-nine cases had complete meat module data. We used Cox proportional hazard models to calculate hazard ratios (HR) and 95% confidence intervals (CI). Total, red, and high-temperature cooked meat intake was positively associated with pancreatic cancer among men (fifth versus first quintile: HR, 1.41, 95% CI, 1.08-1.83, P trend = 0.001; HR, 1.42, 95% CI, 1.05-1.91, P trend = 0.01; and HR, 1.52, 95% CI, 1.12-2.06, P trend = 0.005, respectively), but not women. Men showed significant 50% increased risks for the highest tertile of grilled/barbecued and broiled meat and significant doubling of risk for the highest quintile of overall meat-mutagenic activity (P trends < 0.01). The fifth quintile of the heterocyclic amine, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline intake showed a significant 29% (P trend = 0.006) increased risk in men and women combined. These findings support the hypothesis that meat intake, particularly meat cooked at high temperatures and associated mutagens, may play a role in pancreatic cancer development. (Cancer Epidemiol Biomarkers Prev 2007;16(12):2664 -75)

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Meat and Meat-Mutagen Intake and Pancreatic Cancer Risk in the NIH-AARP Cohort

Stolzenberg‐Solomon¹,

Cross²,

Silverman³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

Self Cite

108

128

View full text Add to dashboard Cite

show abstract

“…11,13 In addition, some other studies have observed positive associations with meat-derived HCAs and benzo(a)pyrene, a marker of PAHs, and pancreatic cancer risk. 11,41,42 Regarding fresh red meat intake, we observed a statistically significant inverse association with pancreatic cancer among microscopically verified cases, although this decrease was only observed for the highest versus the lowest quintile. The risk estimates for red meat intake seemed to change, however, during follow-up, although the interaction with time was not significant.…”

Section: Discussionmentioning

confidence: 74%

Meat and fat intake and pancreatic cancer risk in the Netherlands Cohort Study

Heinen

Verhage

Goldbohm³

et al. 2009

Intl Journal of Cancer

View full text Add to dashboard Cite

Meat contains numerous carcinogens, such as heterocyclic amines, polycyclic aromatic hydrocarbons, and N-nitroso compounds, which can be derived either from natural food or during the process of food preparation. These carcinogens may increase pancreatic cancer risk. Furthermore, studies in animals showed that polyunsaturated fatty acids, especially linoleic acid, increase pancreatic cancer risk. We examined prospectively the relation between pancreatic cancer risk and intake of fresh meat, processed meat, fish, eggs, total fat, and different types of fat. The Netherlands Cohort Study consisted of 120,852 men and women who completed a baseline questionnaire in 1986. After 13.3 years of follow-up, 350 pancreatic cancer cases (66% microscopically confirmed) were available for analysis. A validated 150-item foodfrequency questionnaire was used to calculate intake of fresh meat, processed meat, fish, eggs, fat and different types of fat. No association was found when examining the association between intake of fresh meat, other types of meat, fish, eggs, dietary intake of total fat and different types of fat and risk of pancreatic cancer. It is important for future studies to investigate the relation between different meat-cooking methods and pancreatic cancer. ' UICCKey words: pancreatic cancer; meat; dietary fat; cohort study; microscopic confirmation Pancreatic cancer is among the most rapidly fatal cancers worldwide, with a 5-year survival rate of 6% or less.1,2 Since there is no effective way to screen for this malignancy, prevention could have a major impact on pancreatic cancer mortality. So far, cigarette smoking, diabetes mellitus, and body fatness are identified as risk factors. 3-5Based on ecological studies, international variation in incidence rates of pancreatic cancer suggested that per capita intakes of animal protein, fat, and eggs were positively related to this type of cancer.6,7 Since then, numerous epidemiological studies have investigated the relation between meat, eggs, and different types of fat and pancreatic cancer, including 15 prospective cohort studies 3,6,[8][9][10][11][12] and 31 case-control studies. 3,6,[13][14][15][16][17][18][19] In a recent Expert Panel Report, it was concluded that there is limited evidence suggesting that red meat is a cause of pancreatic cancer in humans.3 Data on processed meat, chicken, fish, eggs, dietary fat, and specific fatty acids were either of too low quality, too inconsistent, or the number of studies too few to allow conclusions to be reached.Meat contains numerous carcinogens, such as heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs), and N-nitroso compounds, which can be derived either from natural food or during the process of food preparation. These carcinogens may increase pancreatic cancer risk. 3,20,21 Regarding dietary fat, studies in animals showed that diets high in fat increased the risk of pancreatic cancer compared to low-fat diets, 22 and suggested that polyunsaturated fatty acids (PUFA), especially linoleic acid (LA...

show abstract

Neoplasms of the Exocrine Pancreas

Wolff

Crane

et al. 2017

Holland‐Frei Cancer Medicine

View full text Add to dashboard Cite

Overview Adenocarcinoma of the pancreas is one of the most morbid and lethal malignancies. Worldwide, it accounts for 330,000 deaths annually. Smoking and obesity are both risk factors for pancreatic cancer and current estimates suggest half of all cases may be preventable. Genetic predisposition to pancreatic cancer is associated with some genetic syndromes to include BRCA1 or BRCA2 germline mutations, Peutz–Jeghers syndrome, and hereditary nonpolyposis colon cancer. Somatic mutations in KRAS, CDKN2A/INK4A, TP53, and SMAD4/DPC4 are common. Pancreatic cancer is often diagnosed when the primary tumor is inoperable or there is metastatic spread rendering the cancer incurable. At present, clinical staging defines the malignancy as resectable (and potentially curable), borderline resectable, locally advanced, or metastatic. Surgery with curative intent is possible for patients with resectable disease and for a subset of patients with borderline resectable disease. While chemotherapy has been proved to prolong survival as a component of adjuvant therapy, and as therapy for locally advanced or metastatic disease, the role of radiation therapy in treatment is less‐well defined and not universally accepted. Thus far, molecular targeted therapy has shown no clinically meaningful benefit. Adjuvant and neoadjuvant approaches are employed in patients with resectable and borderline resectable disease. Intense research in the molecular biology of pancreatic cancer continues with increasing interest in the role of the tumor microenvironment in invasion, metastatic potential, and resistance. Novel therapeutic strategies that focus on stromal modification and immunologic manipulation are at the forefront of clinical and translational research efforts.

show abstract

Dietary Mutagen Exposure and Risk of Pancreatic Cancer

Cited by 52 publications

References 41 publications

Meat and Meat-Mutagen Intake and Pancreatic Cancer Risk in the NIH-AARP Cohort

Meat and Meat-Mutagen Intake and Pancreatic Cancer Risk in the NIH-AARP Cohort

Meat and fat intake and pancreatic cancer risk in the Netherlands Cohort Study

Neoplasms of the Exocrine Pancreas

Contact Info

Product

Resources

About