Dietary natural cocoa ameliorates disrupted circadian rhythms in locomotor activity and sleep-wake cycles in mice with chronic sleep disorders caused by psychophysiological stress

Oishi, Katsutaka; Okauchi, Hiroki; Yamamoto, Saori; Higo-Yamamoto, Sayaka

doi:10.1016/j.nut.2020.110751

Cited by 11 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, compared with the control, the CRS-treated mice had increased wakefulness in the light phase, especially during ZT 6–8 ( Figure 2C ). Recently, prolonged (about 4 w) chronic sleep disorders induced by psychophysiological stress have been shown to lead to increased arousal in mice ( Oishi et al, 2020 ). The higher episode numbers of wake and NREM led to greater NREM sleep fragmentation during the light phase ( Figures 3B,D ).…”

Section: Discussionmentioning

confidence: 99%

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice

et al. 2023

View full text Add to dashboard Cite

Stress may trigger sleep disorders and are also risk factors for depression. The study explored the melatonin-related mechanisms of stress-associated sleep disorders on a mouse model of chronic stress by exploring the alteration in sleep architecture, melatonin, and related small molecule levels, transcription and expression of melatonin-related genes as well as proteins. Mice undergoing chronic restraint stress modeling for 28 days showed body weight loss and reduced locomotor activity. Sleep fragmentation, circadian rhythm disorders, and insomnia exhibited in CRS-treated mice formed sleep disorders. Tryptophan and 5-hydroxytryptamine levels were increased in the hypothalamus, while melatonin level was decreased. The transcription and expression of melatonin receptors were reduced, and circadian rhythm related genes were altered. Expression of downstream effectors to melatonin receptors was also affected. These results identified sleep disorders in a mice model of chronic stress. The alteration of melatonin-related pathways was shown to trigger sleep disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Cocoa increased hypothalamic mRNA expression of Hspa1 in control mice (encodes HSP70) which are associated with sleep regulation. However, cocoa did not induce Hspa1 expression in CSD35 mice (51). The effects of black ginger (Kaempferia parviflora) on disruption of circadian rhythms and expression of circadian clock genes were investigated in vivo and in vitro experiments.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2018

TFK

View full text Add to dashboard Cite

The circadian rhythm works as a clock that regulates many physiological processes including metabolism, sleep, neurobehavior, epigenetic and hormone secretion so that disruption of the circadian rhythm causes adverse effects on human health. The mutations in DNA increase the risk of developing cancer (a genetic disease caused by genome damage). Cancer formation is also caused by disruption of the circadian rhythm. Therefore, a cell's ability to properly respond to DNA damage and repair DNA is critical in preventing cancer formation. Prevention of DNA damage is important for the occurrence of cancer. Epidemiological and experimental evidence explain the variation of dietary intake effects in cancer prevalence. Dietary factors may affect the efficiency of DNA repair, their effectiveness on epigenetic mechanisms, as well as circadian rhythm and inhibit cancer formation. The purpose of this review is to reveal the effects of nutrition on circadian rhythm and DNA repair, emphasize the scarcity of existing studies, and pave the way for possible experimental studies. There are very few studies in this field, and the future studies of nutrients that affect circadian rhythm are very valuable in order to find new solutions in cancer treatment. Nutrition may have many effects on the circadian system and DNA repair, and ultimately help reduce the burden of chronic diseases.

show abstract

“…Dietary cocoa intake was also capable of alleviating disruptions in central circadian rhythms induced by a high fat/high sucrose diet, as well as chronic sleep disorders in mice. [107] Other chronobiologically active compounds such as sesamin isomers (sesamin and episesamin) have also been investigated, whereby the administration of sesamin isomers with olive oil at the beginning of the active phase was able to improve lipid metabolism in mice where dyslipidemia was induced after a prolonged (28 days) high fat diet, by regulating the expression of genes involved in cholesterol metabolism as well as liver clock genes. [108] More recently, the venture into novel nutraceuticals/bioactives as chronobiotics in the treatment of circadian desynchrony has shown promising results.…”

Section: Non-nutrient Bioactivesmentioning

confidence: 99%

“…Dietary cocoa intake was also capable of alleviating disruptions in central circadian rhythms induced by a high fat/high sucrose diet, as well as chronic sleep disorders in mice. [ 107 ]…”

Section: Dietary Components Intake Timing and Their Interaction With ...mentioning

confidence: 99%

Is There a Utility of Chrono‐Specific Diets in Improving Cardiometabolic Health?

Yong

Henry

Haldar

2022

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Modern lifestyle is generally associated with the consumption of three main meals per day, one of which is typically in the evening or at night. It is also well established that consumption of meals in the later part of the day, notably in the evenings, is associated with circadian desynchrony, which in turn increases the risk of non-communicable diseases, particularly cardiometabolic diseases. While it is not feasible to avoid food consumption during the evenings altogether, there is an opportunity to provide chrono-specific, diet-based solutions to mitigate some of these risks. To date, there has been substantial progress in the understanding of chrononutrition, with evidence derived mainly from in vitro and in vivo animal studies. Some of these approaches include the manipulation of the quality and quantity of certain nutrients to be consumed at specific times of the day, as well as incorporating certain dietary components (macronutrients, micronutrients, or non-nutrient bioactives, including polyphenols) with the ability to modulate circadian rhythmicity. However, robust human studies are generally lacking. In this review, the study has consolidated and critically appraised the current evidence base, with an aim to translate these findings to improve cardiometabolic health and provides recommendations to move this field forward.

show abstract

Dietary natural cocoa ameliorates disrupted circadian rhythms in locomotor activity and sleep-wake cycles in mice with chronic sleep disorders caused by psychophysiological stress

Cited by 11 publications

References 33 publications

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice

Untitled

Is There a Utility of Chrono‐Specific Diets in Improving Cardiometabolic Health?

Contact Info

Product

Resources

About