2011
DOI: 10.1007/s00394-011-0192-5
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Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits

Abstract: Purpose In the last decade, a growing scientific and medical interest has emerged toward cardiovascular effects of dietary nitrite and nitrate; however, many questions concerning their mode of action(s) remain unanswered. In this review, we focus on multiple mechanisms that might account for potential cardiovascular beneficial effects of dietary nitrite and nitrate. Results Beneficial changes to cardiovascular health from dietary nitrite and nitrate might result from several mechanism(s) including their redu… Show more

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Cited by 115 publications
(72 citation statements)
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“…Modest dietary intake of inorganic nitrate reduces arterial blood pressure, inhibits platelet function, and prevents endothelial dysfunction in humans (Lundberg et al, 2011;Machha and Schechter, 2011;Pattillo et al, 2011). The findings of the present suggest the existence of an endogenous development of a nitrate-using mechanism in the SHR that may combat endothelial dysfunction.…”
Section: Discussionmentioning
confidence: 54%
“…Modest dietary intake of inorganic nitrate reduces arterial blood pressure, inhibits platelet function, and prevents endothelial dysfunction in humans (Lundberg et al, 2011;Machha and Schechter, 2011;Pattillo et al, 2011). The findings of the present suggest the existence of an endogenous development of a nitrate-using mechanism in the SHR that may combat endothelial dysfunction.…”
Section: Discussionmentioning
confidence: 54%
“…The results are, however, inconsistent with respect to CVD -recent review articles highlighted that total dietary nitrite and nitrate may have cardiovascular protective properties [18] by lowering blood pressure and by having antiplatelet and cytoprotective effects [19]. In contrast, some studies indicated that high concentration of nitrites in diet is related to endothelial dysfunction and impaired insulin response in adults [20].…”
Section: Discussionmentioning
confidence: 88%
“…15 During the manufacturing process of red meat, high amounts of food additives are added. Nitrites are frequently used in the preservation of processed meat (cured meats) and have been suggested to affect the risk of HF, but results are inconsistent-recent review articles highlighted that total dietary nitrite and nitrate may have cardiovascular protective properties 16 by hypotensive, antiplatelet, and cytoprotective effects. 17 In contrast, some studies indicated that high concentration of nitrites in diet is related to endothelial dysfunction and impaired insulin response in adults.…”
Section: Discussionmentioning
confidence: 99%