2011
DOI: 10.2174/138945011796150334
|View full text |Cite
|
Sign up to set email alerts
|

Dietary Nitrite in Nitric Oxide Biology: A Redox Interplay with Implications for Pathophysiology and Therapeutics

Abstract: Until recently, nitrite has been considered a stable oxidation inert metabolite of nitric oxide ((∙)NO) metabolism. This view is now changing as it has been shown that nitrite can be reduced back to (∙)NO and thus one may consider a reversible interaction regarding (∙)NO:nitrite couple. Not only physiological regulatory actions have been assigned to nitrite but also may represent, in addition to nitrate, the largest (∙)NO reservoir in the body. This notion has obvious importance when considering that (∙)NO is … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
34
0
6

Year Published

2013
2013
2019
2019

Publication Types

Select...
4
3
2

Relationship

0
9

Authors

Journals

citations
Cited by 56 publications
(40 citation statements)
references
References 145 publications
0
34
0
6
Order By: Relevance
“…This reaction has convincingly been shown to occur in the acidic gastric lumen, where NO generation is greatly enhanced by polyphenols or by other reducing agents, such as vitamin C 225,226 . Direct evidence for this reaction also occurring in tissues is still lacking.…”
Section: Guanylyl Cyclase Stimulators and Activatorsmentioning
confidence: 92%
“…This reaction has convincingly been shown to occur in the acidic gastric lumen, where NO generation is greatly enhanced by polyphenols or by other reducing agents, such as vitamin C 225,226 . Direct evidence for this reaction also occurring in tissues is still lacking.…”
Section: Guanylyl Cyclase Stimulators and Activatorsmentioning
confidence: 92%
“…[1] Nitric oxide production encompasses the sequential reduction of nitrate to nitrite in the oral cavity and to  NO in the stomach. Here, a wide range of biological functions has been described for  NO (for a detailed review see [2,3]) but the physiological implications of other bioactive nitrogen oxides are yet to be fully revealed. Recent evidences support the hypothesis of a nitrite-dependent nitrating pathway operating in the stomach and targeting both endogenous proteins and dietary lipids.…”
Section: Introductionmentioning
confidence: 99%
“…O estômago humano pode então ser considerado um biorreator, sendo o ambiente ácido do estômago muito importante para a formação de NO e espécies bioativas de nitrogênio a partir do nitrito (Richardson et al 2002;Rocha et al 2011). …”
Section: Conversão Não Enzimática Do Nitrito a Nounclassified
“…Houve uma correlação negativa entre o aumento do pH gástrico e a formação de NO e essa formação está correlacionado positivamente com a formação de espécies nitrosiladas nos tratamentos com as drogas e os tampões, sugerindo que o pH ácido do estômago propicia a formação dessas moléculas e o aumento do pH reduz essa formação, confirmando a importância do ambiente ácido do estômago na formação não enzimática de NO e espécies nitrosiladas a partir do nitrito (Richardson et al 2002;Rocha et al 2011 …”
Section: Constatouunclassified