Dietary oleacein, a secoiridoid from extra virgin olive oil, prevents collagen-induced arthritis in mice

Rosillo, María Ángeles; Villegas, Isabel; Vázquez-Román, Victoria; Fernández-Santos, José María; Ortega-Vidal, Juan; Salido, Sofía; González-Rodríguez, María Luisa; Alarcón-de-la-Lastra, Catalina

doi:10.1039/d3fo04240e

Cited by 3 publications

(1 citation statement)

References 60 publications

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“…Several studies have focused on EVOO and its compounds, showing beneficial effects on body weight (quantitative reduction) [ 112 ], adipose tissue (quantitative reduction and positive metabolic modulation) [ 113 , 114 ], lipidic ratio (reduction of total cholesterol (TC), TC/high-density lipoproteins (HDL), and low-density lipoprotein (LDL) oxidation; increase of HDL concentrations) [ 115 , 116 ], glycemic metabolism (reduction of T2DM incidence, fasting glucose, and advanced glycosylated end-products, including glycated hemoglobin; activation of the glucagon-like peptide-1 (GLP-1) incretin-pattern) [ 117 , 118 , 119 , 120 ], and cardiovascular risk (reduction of LDL oxidation, systolic blood pressure, and cardiovascular events, improvement of nitric oxide (NO)-mediated endothelial function) [ 121 , 122 , 123 , 124 ]. To a further extent, but with a lesser degree of evidence (mostly preclinical studies), EVOO intake showed effectiveness in the reduction/modulation of autoimmune [ 125 , 126 , 127 , 128 , 129 ], inflammatory bowel [ 130 , 131 , 132 , 133 ], neurodegenerative [ 134 , 135 , 136 , 137 , 138 ], and neoplastic diseases [ 137 , 139 , 140 ], as well as gut microbiota alterations [ 141 , 142 , 143 , 144 ].…”

Section: The Role Of Lifestyle Modificationsmentioning

confidence: 99%

Oxidative Stress as a Target for Non-Pharmacological Intervention in MAFLD: Could There Be a Role for EVOO?

Seidita,

Cusimano,

Giuliano

et al. 2024

Antioxidants

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Oxidative stress plays a central role in most chronic liver diseases and, in particular, in metabolic dysfunction-associated fatty liver disease (MAFLD), the new definition of an old condition known as non-alcoholic fatty liver disease (NAFLD). The mechanisms leading to hepatocellular fat accumulation in genetically predisposed individuals who adopt a sedentary lifestyle and consume an obesogenic diet progress through mitochondrial and endoplasmic reticulum dysfunction, which amplifies reactive oxygen species (ROS) production, lipid peroxidation, malondialdehyde (MDA) formation, and influence the release of chronic inflammation and liver damage biomarkers, such as pro-inflammatory cytokines. This close pathogenetic link has been a key stimulus in the search for therapeutic approaches targeting oxidative stress to treat steatosis, and a number of clinical trials have been conducted to date on subjects with NAFLD using drugs as well as supplements or nutraceutical products. Vitamin E, Vitamin D, and Silybin are the most studied substances, but several non-pharmacological approaches have also been explored, especially lifestyle and diet modifications. Among the dietary approaches, the Mediterranean Diet (MD) seems to be the most reliable for affecting liver steatosis, probably with the added value of the presence of extra virgin olive oil (EVOO), a healthy food with a high content of monounsaturated fatty acids, especially oleic acid, and variable concentrations of phenols (oleocanthal) and phenolic alcohols, such as hydroxytyrosol (HT) and tyrosol (Tyr). In this review, we focus on non-pharmacological interventions in MAFLD treatment that target oxidative stress and, in particular, on the role of EVOO as one of the main antioxidant components of the MD.

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