2013
DOI: 10.1097/hjh.0b013e328362215d
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Dietary omega-3 fatty acids attenuate myocardial arrhythmogenic factors and propensity of the heart to lethal arrhythmias in a rodent model of human essential hypertension

Abstract: Findings suggest that amelioration of myocardial Cx43-related abnormalities, positive modulation of PKC pathways, and normalization of MyHC can significantly contribute to the antiarrhythmic effects of omega-3 in rat model mimicking human essential hypertension. Our results support the prophylactic use of omega-3 to minimize cardiovascular risk and sudden arrhythmic death.

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Cited by 33 publications
(35 citation statements)
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“…Omega-3 intake resulted in clear preservation of the integrity of cardiomyocyte mitochondria and cell membranes as well as capillaries. It appears that an improvement in myocardial ultrastructure is a characteristic feature of omega-3 treatment that has also been demonstrated in hereditary hypertriglyceridemic rats and SHR (Bacova et al 2010, Radosinska et al 2013. These findings suggest that increased incorporation of omega-3 (EPA and/or DHA) into cardiomyocyte and mitochondrial membranes most likely accounts for the protection of their integrity.…”
Section: Discussionmentioning
confidence: 82%
“…Omega-3 intake resulted in clear preservation of the integrity of cardiomyocyte mitochondria and cell membranes as well as capillaries. It appears that an improvement in myocardial ultrastructure is a characteristic feature of omega-3 treatment that has also been demonstrated in hereditary hypertriglyceridemic rats and SHR (Bacova et al 2010, Radosinska et al 2013. These findings suggest that increased incorporation of omega-3 (EPA and/or DHA) into cardiomyocyte and mitochondrial membranes most likely accounts for the protection of their integrity.…”
Section: Discussionmentioning
confidence: 82%
“…The results obtained differ in terms of Cx43 expression with Cx43 being up-regulated and phosphorylation of Cx43 being increased (Bacova et al, 2010; Bacova et al, 2012; Benova et al, 2013; Fialova et al, 2008; Mitasikova et al, 2008; Radosinska et al, 2011; Radosinska et al, 2013; Zhao et al, 2008) in some studies and Cx43 expression being decreased (Bacharova et al, 2008; Zhang et al, 2014) in others. Part of the observed differences might relate to the degree of left ventricular hypertrophy associated with hypertension, since in human hearts mild hypertrophy increased while extensive hypertrophy reduced left ventricular Cx43 expression (Kostin et al, 2004).…”
Section: Cx43 Function In the Presence Of Major Cardiovascular Rismentioning
confidence: 99%
“…This post-translational modification has been associated with the disassembly and/or closure of Cx43-GJCs (Huang et al, 2004; Solan and Lampe, 2014). Accordingly, DHA alone or with EPA increases Cx43 phosphorylation in rat astrocytes and vascular endothelial cells (Champeil-Potokar et al, 2006; Dlugosova et al, 2009; Radosinska et al, 2013). The participation of different protein kinases, such as PKA, PKC-epsilon, PI3K, AKT, Src, or MEK1/2, has been observed in this type of Cx regulation (Popp et al, 2002; De Vuyst et al, 2007; Figueroa et al, 2013; Radosinska et al, 2013).…”
Section: Connexin Modifications Induced By Fatty Acidsmentioning
confidence: 99%