Dietary omega-3 fatty acids attenuate cellular damage after a hippocampal ischemic insult in adult rats

Moreira, Júlia Dubois; Knorr, Luisa; Thomazi, Ana Paula; Simão, Fabrício; Battu, Cintia Eickhoff; Oses, Jean Pierre; Gottfried, Carmem; Wofchuk, Susana Tchernin; Salbego, Christianne Gazzana; Souza, Diogo O.; Perry, Marcos Luiz Santos; Vinadé, Lúcia

doi:10.1016/j.jnutbio.2009.01.013

Cited by 32 publications

(21 citation statements)

References 52 publications

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“…Oxidation of fats and proteins from lipoproteins and cell membranes decreases fat transport causing cell damage and leading to heart disorders (APPOLINÁRIO et al, 2011). LDL transports cholesterol from the liver to peripheral arterial smooth muscle cells, and high LDL levels can cause cholesterol deposition within the arteries of the heart, a risk factor for the development of heart disease (MOREIRA et al, 2010;LUZIA;JORGE, 2011).…”

Section: Weight Evolutionmentioning

confidence: 99%

Sesame and flaxseed oil: nutritional quality and effects on serum lipids and glucose in rats

et al. 2013

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This study evaluated the nutritional value of sesame and flaxseed oils and their effects on the lipid and glucose profile of rats fed diets containing different fat combinations. Fatty acid composition, refractive index, and iodine and saponification values were analyzed to characterize the oils. In the biological assay, Wistar rats were fed different diets, whose fat composition consisted of varying combinations of flaxseed oil, sesame oil, and animal fat. The primary constituents of the sesame oil were oleic (28.6%), linoleic (28.4%), and lauric acid (14.6%); for the flaxseed oil they were alpha-linolenic (39.90%), oleic (17.97%) and linoleic acid (12.25%). The iodine and saponification values of the oils were within the reference range. Rats fed flaxseed oil-based diets had the lowest serum cholesterol values, whereas rats fed diets with flaxseed oil + sesame oil + animal fat had the highest glucose levels. HDL levels decreased significantly with flaxseed oil. Sesame and flaxseed oils are sources of polyunsaturated fatty acids (PUFA), and the flaxseed oil-based diet had a hypocholesterolemic effect, whereas sesame oil showed oxidative stability since it contains high levels of monounsaturated and saturated fatty acids.

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Section: Weight Evolutionmentioning

confidence: 99%

Sesame and flaxseed oil: nutritional quality and effects on serum lipids and glucose in rats

et al. 2013

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“…3PUFAs are important for cell protection after ischemia and also seem to play an important role in the activation of antiapoptotic signaling pathways after IR in brain and heart [9,10]. We hypothesized that 3PUFAs may exert their beneficial effects in intestinal IR by shifting eicosanoid synthesis to less inflammatory species, by modulating tissue levels of certain cytokines, by treating associated liver disease, or by enhancing bile flow.…”

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confidence: 99%

Parenteral omega-3 fatty acids (Omegaven) modulate intestinal recovery after intestinal ischemia-reperfusion in a rat model

Sukhotnik

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Pollak

et al. 2011

Journal of Pediatric Surgery

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“…Among the omega-3 PUFAs, docosahexaenoic acid DHA is the most important omega-3 with physiological significance for brain function. Omega-3 dietary deficiency affects the dopaminergic, serotoninergic and glutamatergic systems 34 . As a component of membrane phospholipids, it is documented that the percentage of omega-3 influences the physicochemical properties of the membrane and accordingly affect the function of a variety of membrane-bound proteins, including dopaminergic, GABAergic, and cholinergic receptors 35 .…”

Section: Resultsmentioning

confidence: 99%

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2017

IJPSR

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ABSTRACT:The present study was designed to evaluate the protective effect of omega-3 against β-cyfluthrin (β-cyf)-induced neurotransmitters' impairment, oxidative damage, testicular toxicity and genotoxicity. Adult male Wistar rats were divided equally into four groups: Group (I): Control, Group (II): β-cyf (5 mg/kg body weight/day), Group (III): omega-3 (400 mg/kg body weight/da y) + β-cyf (5 mg/kg body weight/day), Group (IV): omega-3 (400 mg/kg body weight/day). β-cyf's treatment for 8 weeks inhibited the activities of AChE, DA, LDH, total ATPase and Na + /K + ATPase. Also, β-cyf resulted in an increase in oxidative stress as indicated by elevations in the levels of MDA and NO while, the levels of TAC, thiol content and TP were decreased in brain and testis. Sperm count, sperm motility and testosterone levels were reduced while, sperm abnormalities, FSH and LH levels were increased in β-cyf-treated group. Also, β-cyf administration led to a significant increase in TNFα, IL-6 and APP mRNA expressions. In addition, β-cyf caused histopathological alterations in brain and testis. The present results showed that omega-3 could improve all the measured parameters. In conclusion, omega-3 could exhibit protective effects against β-cyf induced neurological and testicular damage.

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Dietary omega-3 fatty acids attenuate cellular damage after a hippocampal ischemic insult in adult rats

Cited by 32 publications

References 52 publications

Sesame and flaxseed oil: nutritional quality and effects on serum lipids and glucose in rats

Sesame and flaxseed oil: nutritional quality and effects on serum lipids and glucose in rats

Parenteral omega-3 fatty acids (Omegaven) modulate intestinal recovery after intestinal ischemia-reperfusion in a rat model

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