Dietary ortho phenols that induce glutathione S-transferase and increase the resistance of cells to hydrogen peroxide are potential cancer chemopreventives that act by two mechanisms: the alleviation of oxidative stress and the detoxification of mutagenic xenobiotics

Fiander, H.

doi:10.1016/s0304-3835(00)00368-2

Cited by 88 publications

(39 citation statements)

References 32 publications

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“…29 A previous study indicated that some dietary orthophenols can induce GST and therefore increase the resistance of cells to oxidative stress. 45 There are many biologically plausible reasons why the consumption of plant foods might slow or prevent the emergence of cancer. At almost every stage of the cancer process, identified phytochemicals are known to be able to alter the likelihood of carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer

Kellen

Zeegers

Paulussen

et al. 2006

Intl Journal of Cancer

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We have hypothesized that consumption of fruit and vegetables may be associated with reduced risk of bladder cancer and that this may interact with cigarette smoking and metabolic genetic polymorphisms. A population-based case-control study was performed in the Belgian province of Limburg among 200 cases and 385 controls. Logistic regression was performed to calculate odds ratios (ORs) for bladder cancer occurrence with corresponding 95% confidence intervals (95% CI). Effect modification by smoking was investigated. We also evaluated interaction between fruit intake and GSTM1, GSTT1, NAT2 and SULT1A1 amongst ''ever-smokers.'' Total vegetable intake was not significantly associated with the risk of bladder cancer (OR 1.15, 95% CI: 0.70-1.88 for the highest compared to the lowest tertile). However, total fruit intake was negatively associated with bladder cancer risk (OR 0.61, 95% CI 0.37-0.99 comparing the same tertiles). Among individuals with low daily fruit consumption, ever smokers had a highly increased risk of bladder cancer risk (OR: 4.23, 95% CI: 1.91-9.40). By increasing the daily fruit consumption, the risk of ''ever-smokers'' for developing bladder cancer decreased, however it remained significant (OR: 2.15; 95CI%: 1.15-4.05). No interaction was identified between the different genotypes and fruit consumption. We conclude that fruit consumption may decrease the effect of smoking on developing bladder cancer. Antioxidants, found in fruit, may protect against the damage caused by free radicals found in cigarette smoke. Metabolic polymorphisms appear not to modify this relation. ' 2005 Wiley-Liss, Inc.Key words: bladder cancer; fruit and vegetable intake; cigarette smoking; genetic polymorphisms An estimated 357,000 cases of bladder cancer occurred worldwide in 2002, making this the ninth most commonly occurring cancer for both sexes combined. There were 145,000 deaths, with population-based 5-year survival rates ranging from 40 to 80% depending on whether noninvasive lesions were included in the computation or not. Bladder cancer is relatively common in developed countries, where 63% of all incident cases are diagnosed.

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Section: Discussionmentioning

confidence: 99%

Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer

Kellen

Zeegers

Paulussen

et al. 2006

Intl Journal of Cancer

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“…66 Polyphenols can also behave as detoxifying enzyme inducers, modulating gene expression including induction of phase II enzymes, such as glutathione S-transferases (GST) and quinone reductases (QR), which usually leads to protection of cells/tissues against exogenous and/or endogenous carcinogenic intermediates. 67 The antioxidant/electrophile response element (ARE/EpRE) found at the 5 0 -flanking region of these phase II genes may play important roles in mediating their induction by xenobiotics (including phenolic compounds 68 ). Phase II gene inducers also activate MAPK kinases and are involved in the transcription activation of ARE-mediated reporter gene.…”

Section: G Antioxidant and Anti-inflammatory Effectsmentioning

confidence: 99%

New insights on the anticancer properties of dietary polyphenols

et al. 2006

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Cancer, one of the major causes of death across the world, has shown to be a largely preventable disease, highly susceptible to modulation by dietary factors. Phenolic compounds, abundant in vegetables and fruits ubiquitous in diet, were described to play an important role as chemopreventive agents. Since conventional therapeutic and surgical approaches have not been able to control the incidence of most cancer types, the development of chemopreventive strategies is an urgent priority in public health. The current diet phenolic intake is often insufficient to protect from mutagens (either exogenous or endogenous), which leads to the need for dietary supplementation as an alternative approach. Research efforts are placing increasing emphasis on identifying the biological mechanisms and in particular the signal transduction pathways related to the chemopreventive activities of these compounds. These effects are believed to occur by the regulation of signaling pathways such as nuclear factor-kB (NF-kB), activator protein-1 (AP-1) or mitogen-activated protein kinases (MAPK). Dietary polyphenols can exert their effects on these pathways separately or sequentially and in addition the occurrence of crosstalk between these pathways cannot be overlooked. By modulating cell signaling pathways, polyphenols activate cell death signals and induce apoptosis in precancerous or malignant cells resulting in the inhibition of cancer development or progression. However, regulation of cell signaling pathways by dietary polyphenols can also lead to cell proliferation/survival or inflammatory responses due to increased expression of several genes. The present review summarizes the most recent advances providing new insights into the molecular mechanisms underlying the promising anticarcinogenic activity of dietary polyphenols. ß

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“…Flavonoids have abilities to scavenge the free radicals because they stimulate the activity of glutathione-S-transferase, the enzyme ensures the safety of cells damaged by free radicals [30] . The antioxidant property of flavonoids is totally dependent on their chemical configurations.…”

Section: Resultsmentioning

confidence: 99%

In vitro and in vivo Evaluation of Flavonoids from Heliotropium ellipticum Exudate for Antioxidant, Antineoplastic and Cytotoxic Activities II

Singh¹,

Sahu²,

Sharma³

2017

pharmaceutical-sciences

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Dietary ortho phenols that induce glutathione S-transferase and increase the resistance of cells to hydrogen peroxide are potential cancer chemopreventives that act by two mechanisms: the alleviation of oxidative stress and the detoxification of mutagenic xenobiotics

Cited by 88 publications

References 32 publications

Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer

Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer

New insights on the anticancer properties of dietary polyphenols

In vitro and in vivo Evaluation of Flavonoids from Heliotropium ellipticum Exudate for Antioxidant, Antineoplastic and Cytotoxic Activities II

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